Analytical methodology for the detection of β2-agonists in urine by gas chromatography-mass spectrometry for application in doping control

Analytica Chimica Acta

Volumn 418, Issue 1, 2000, Pages 79-92

  Ventura, Rosa ^a,b   Damasceno, Lúcia ^a,c   Farré, Magí ^a,d   Cardoso, Jari ^c   Segura, Jordi ^a,b  

^a INST MUNIC D INVESTIGACIO MEDICA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

2 Agonists; Doping analysis; Gas chromatography mass spectrometry

Indexed keywords

2 PROPANOL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; FENOTEROL; FORMOTEROL; FORMOTEROL FUMARATE; PENBUTOLOL; REPROTEROL; SALBUTAMOL; SALMETEROL; TERBUTALINE;

ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DOPING; HUMAN; HYDROLYSIS; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; SCREENING; SOLID PHASE EXTRACTION; SPORT; TECHNIQUE; URINALYSIS; URINE;

EID: 0034256039     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(00)00950-8     Document Type: Article

References (29)

1. F.S. Virant, in: J.M. Weiler (Ed.), Allergic and Respiratory Disease in Sports Medicine, Marcel Dekker, New York, 1997, p. 65.
2. Martineau L., Horan M.A., Rothwell N.J., Little R.A. Clin. Sci. 8:1992;615.
3. International Olympic Committee, Prohibited classes of substances and prohibited methods, in: IOC Medical Code and Explanatory Document, IOC, Lausanne, Switzerland, 1995.
4. Morgan D.J. Clin. Pharmacokinet. 18:1990;270.
5. Sitar D.S. Clin. Pharmacokinet. 31:1996;246.
6. Nyberg L., Rosenborg J., Weibull E., Jönsson S., Kennedy B.M., Nilsson M. Br. J. Clin. Pharmacol. 45:1998;471.
7. Manchee G.R., Barrow A., Kulkarni S., Palmer E., Oxford J., Colthup P.V., Maconochie J.G., Tarbit M.H. Drug Metab. Dispos. 21:1993;1022.
8. Buchwald A., Hochhaus G. Int. J. Clin. Pharmacol. Ther. 36:1988;652.
9. Kamimura H., Sasaki H., Higughi S., Shiobara Y. J. Chromatogr. 229:1982;337.
10. Lindberg C., Jönsson S., Paulson J., Tunek A. Biomed. Environ. Mass Spectrom. 19:1990;218.
11. Polettini A., Ricossa M.C., Groppi A., Montagna M. J. Chromatogr. 564:1991;529.
12. van den Berg B.T.J., Portier E.J.G., Van den Berg M., Braat M.C.P., van Boxtel C.J. Ther. Drug Monitor. 16:1994;196.
13. Georgakopoulos C.G., Tsitsimpikou C., Spyridaki M.-H.E. J. Chromatogr. B. 726:1999;141.
14. Ventura R., González G., Smeyers M.T., de la Torre R., Segura J. J. Anal. Toxicol. 22:1998;127.
15. Dumasia M.C., Houghton E. J. Chromatogr. 564:1991;503.
16. Leyssens L., Driessen C., Jacobs A., Czech J., Raus J. J. Chromatogr. 564:1991;515.
17. Van Ginkel L.A., Stephany R.W., Van Rossum H.J. J. AOAC Int. 75:1992;554.
18. Montrade M.-P., Le Bizec B., Monteau F., Siliart B., Andre F. Anal. Chim. Acta. 275:1993;253.
19. Hooijerink H., Schilt R., van Bennekom E.O., Huf F.A. J. Chromatogr. B. 660:1994;303.
20. Solans A., Carnicero M., de la Torre R., Segura J. J. Anal. Toxicol. 19:1995;104.
21. Van Vyncht G., Preece S., Gaspar P., Maghuin-Rogister G., DePauw E. J. Chromatogr. A. 750:1996;43.
22. Couper F.J., Drummer O.H. J. Chromatogr. B. 685:1996;265.
23. Ramos F., Castilho M.C., Silveira M.I.N. J. AOAC Int. 81:1998;544.
24. Ramos F., Santos C., Silva A., Silveira M.I.N. J. Chromatogr. B. 716:1998;366.
25. L. Damasceno, R. Ventura, J. Ortuño, J. Segura, J. Mass Spectrom., submitted for publication.
26. International Olympic Committee, Analytical criteria for reporting low concentrations of anabolic steroids, Internal Communication, IOC, Lausanne, Switzerland, 1998.
27. International Laboratory Accreditation Cooperation, Accreditation requirements and operating criteria for horseracing laboratories, ILAC-G7, 1996. http://www.ilac.org/.
28. International Conference on Harmonisation, Validation of Analytical Procedures: Methodology, ICH Topic Q2B, 1996. http://www.ifpma.org/ich5q.html#Analytical.
29. D. De Boer, M. Van Beek, C.H.J. Bekkers, R.A.A. Maes, Recent advances in doping analyses (4), in: W. Schänzer, H. Geyer, A. Gotzmann, U. Mareck-Engelke (Eds.), Proceedings of the 14th Cologne Workshop on Dope Analysis, Sport und Buch Strauβ, Köln, 1997, p. 357.