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Volumn 39, Issue 3, 2010, Pages 301-307

The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells

Author keywords

Angiogenesis; Pancreatic cancer; RON; VEGF

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; RECEPTEUR D ORIGINE NANTAIS TYROSINE KINASE RECEPTOR; SCATTER FACTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 77950285105     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181bb9f73     Document Type: Article
Times cited : (21)

References (45)
  • 1
    • 12244294062 scopus 로고    scopus 로고
    • Biology of angiogenesis in tumors of the gastrointestinal tract
    • Reinmuth N, Parikh AA, Ahmad SA, et al. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech. 2003;60: 199-207.
    • (2003) Microsc Res Tech , vol.60 , pp. 199-207
    • Reinmuth, N.1    Parikh, A.A.2    Ahmad, S.A.3
  • 2
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • Fidler IJ, Ellis LM. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell. 1994;79:185-188.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 3
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst. 1990;82:4-6.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 4
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasisVcorrelation in invasive breast carcinoma
    • Weidner N, Semple JP, Welch WR, et al. Tumor angiogenesis and metastasisVcorrelation in invasive breast carcinoma. N Engl J Med. 1991;324:1-8.
    • (1991) N Engl J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3
  • 5
    • 0034075041 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
    • Lee JC, Chow NH, Wang ST, et al. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur J Cancer. 2000;36:748-753.
    • (2000) Eur J Cancer , vol.36 , pp. 748-753
    • Lee, J.C.1    Chow, N.H.2    Wang, S.T.3
  • 6
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD, et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. 1995;55:3964-3968.
    • (1995) Cancer Res , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3
  • 7
    • 0029857184 scopus 로고    scopus 로고
    • Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer
    • Takahashi Y, Cleary KR, Mai M, et al. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin Cancer Res. 1996;2:1679-1684.
    • (1996) Clin Cancer Res , vol.2 , pp. 1679-1684
    • Takahashi, Y.1    Cleary, K.R.2    Mai, M.3
  • 8
    • 0030066037 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in gastric carcinoma
    • Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma. Cancer. 1996;77:858-863.
    • (1996) Cancer , vol.77 , pp. 858-863
    • Maeda, K.1    Chung, Y.S.2    Ogawa, Y.3
  • 9
    • 0036894180 scopus 로고    scopus 로고
    • VEGF-RII influences the prognosis of pancreatic cancer
    • discussion 749
    • Buchler P, Reber HA, Buchler MW, et al. VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg. 2002;236:738-749; discussion 749.
    • (2002) Ann Surg , vol.236 , pp. 738-749
    • Buchler, P.1    Reber, H.A.2    Buchler, M.W.3
  • 10
    • 0030754056 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
    • Itakura J, Ishiwata T, Friess H, et al. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res. 1997;3:1309-1316.
    • (1997) Clin Cancer Res , vol.3 , pp. 1309-1316
    • Itakura, J.1    Ishiwata, T.2    Friess, H.3
  • 11
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer. 2000;88:2239-2245.
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3
  • 12
    • 49949152069 scopus 로고    scopus 로고
    • Mechanisms of adaptive angiogenesis to tissue hypoxia
    • Fong GH. Mechanisms of adaptive angiogenesis to tissue hypoxia. Angiogenesis. 2008;11:121-140.
    • (2008) Angiogenesis , vol.11 , pp. 121-140
    • Fong, G.H.1
  • 13
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998;394:485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 14
    • 0032170035 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I
    • Akagi Y, Liu W, Zebrowski B, et al. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res. 1998;58:4008-4014.
    • (1998) Cancer Res , vol.58 , pp. 4008-4014
    • Akagi, Y.1    Liu, W.2    Zebrowski, B.3
  • 15
    • 0033119572 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
    • Wang D, Huang HJ, Kazlauskas A, et al. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 1999;59:1464-1472.
    • (1999) Cancer Res , vol.59 , pp. 1464-1472
    • Wang, D.1    Huang, H.J.2    Kazlauskas, A.3
  • 16
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol. 1997;151:1523-1530.
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 17
    • 0034667464 scopus 로고    scopus 로고
    • Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3¶-kinase and distinct from that induced by hypoxia
    • Maity A, Pore N, Lee J, et al. Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3¶-kinase and distinct from that induced by hypoxia. Cancer Res. 2000;60:5879-5886.
    • (2000) Cancer Res , vol.60 , pp. 5879-5886
    • Maity, A.1    Pore, N.2    Lee, J.3
  • 18
    • 0034647770 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways
    • Miele C, Rochford JJ, Filippa N, et al. Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways. J Biol Chem. 2000;275:21695-21702.
    • (2000) J Biol Chem , vol.275 , pp. 21695-21702
    • Miele, C.1    Rochford, J.J.2    Filippa, N.3
  • 19
    • 23844435559 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through egr-1 in head and neck squamous cell carcinoma
    • Worden B, Yang XP, Lee TL, et al. Hepatocyte growth factor/scatter factor differentially regulates expression of proangiogenic factors through egr-1 in head and neck squamous cell carcinoma. Cancer Res. 2005;65:7071-7080.
    • (2005) Cancer Res , vol.65 , pp. 7071-7080
    • Worden, B.1    Yang, X.P.2    Lee, T.L.3
  • 20
    • 0035976843 scopus 로고    scopus 로고
    • Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo
    • Toyoda M, Takayama H, Horiguchi N, et al. Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo. FEBS Lett. 2001;509:95-100.
    • (2001) FEBS Lett , vol.509 , pp. 95-100
    • Toyoda, M.1    Takayama, H.2    Horiguchi, N.3
  • 21
    • 0035421326 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma
    • Dong G, Chen Z, Li ZY, et al. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma. Cancer Res. 2001;61:5911-5918.
    • (2001) Cancer Res , vol.61 , pp. 5911-5918
    • Dong, G.1    Chen, Z.2    Li, Z.Y.3
  • 22
    • 34447128188 scopus 로고    scopus 로고
    • The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression
    • Thomas RM, Toney K, Fenoglio-Preiser C, et al. The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. Cancer Res. 2007;67:6075-6082.
    • (2007) Cancer Res , vol.67 , pp. 6075-6082
    • Thomas, R.M.1    Toney, K.2    Fenoglio-Preiser, C.3
  • 23
    • 33947211838 scopus 로고    scopus 로고
    • Tyrosine kinase receptor RON in human pancreatic cancer: Expression, function, and validation as a target
    • Camp ER, Yang A, Gray MJ, et al. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. Cancer. 2007;109:1030-1039.
    • (2007) Cancer , vol.109 , pp. 1030-1039
    • Camp, E.R.1    Yang, A.2    Gray, M.J.3
  • 24
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008;321:1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 25
    • 67650385302 scopus 로고    scopus 로고
    • American Cancer Society. Atlanta: American Cancer Society 2009
    • American Cancer Society. Cancer Facts and Figures 2009. Atlanta: American Cancer Society; 2009.
    • (2009) Cancer Facts and Figures
  • 26
    • 0027318311 scopus 로고
    • A novel putative receptor protein tyrosine kinase of the met family
    • Ronsin C, Muscatelli F, Mattei MG, et al. A novel putative receptor protein tyrosine kinase of the met family. Oncogene. 1993;8:1195-1202.
    • (1993) Oncogene , vol.8 , pp. 1195-1202
    • Ronsin, C.1    Muscatelli, F.2    Mattei, M.G.3
  • 27
    • 0028139182 scopus 로고
    • Identification of the RON gene product as the receptor for the human macrophage stimulating protein
    • Wang MH, Ronsin C, Gesnel MC, et al. Identification of the RON gene product as the receptor for the human macrophage stimulating protein. Science. 1994;266:117-119.
    • (1994) Science , vol.266 , pp. 117-119
    • Wang, M.H.1    Ronsin, C.2    Gesnel, M.C.3
  • 28
    • 0028123022 scopus 로고
    • RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
    • Gaudino G, Follenzi A, Naldini L, et al. RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J. 1994;13:3524-3532.
    • (1994) EMBO J , vol.13 , pp. 3524-3532
    • Gaudino, G.1    Follenzi, A.2    Naldini, L.3
  • 29
    • 28044444312 scopus 로고    scopus 로고
    • Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein
    • Carafoli F, Chirgadze DY, Blundell TL, et al. Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein. FEBS J. 2005;272:5799-5807.
    • (2005) FEBS J , vol.272 , pp. 5799-5807
    • Carafoli, F.1    Chirgadze, D.Y.2    Blundell, T.L.3
  • 30
    • 0029959639 scopus 로고    scopus 로고
    • STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
    • Iwama A, Yamaguchi N, Suda T. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J. 1996;15:5866-5875.
    • (1996) EMBO J , vol.15 , pp. 5866-5875
    • Iwama, A.1    Yamaguchi, N.2    Suda, T.3
  • 31
    • 0035959871 scopus 로고    scopus 로고
    • Point mutations and overexpression of RON induce transformation, tumor formation, and metastasis
    • Peace BE, Hughes MJ, Degen SJ, et al. Point mutations and overexpression of RON induce transformation, tumor formation, and metastasis. Oncogene. 2001;20:6142-6151.
    • (2001) Oncogene , vol.20 , pp. 6142-6151
    • Peace, B.E.1    Hughes, M.J.2    Degen, S.J.3
  • 32
    • 0030578404 scopus 로고    scopus 로고
    • Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes
    • Wang MH, Dlugosz AA, Sun Y, et al. Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res. 1996;226:39-46.
    • (1996) Exp Cell Res , vol.226 , pp. 39-46
    • Wang, M.H.1    Dlugosz, A.A.2    Sun, Y.3
  • 33
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 2005;7:469-483.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 34
    • 0035671571 scopus 로고    scopus 로고
    • Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo
    • Donovan D, Brown NJ, Bishop ET, et al. Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo. Angiogenesis. 2001;4:113-121.
    • (2001) Angiogenesis , vol.4 , pp. 113-121
    • Donovan, D.1    Brown, N.J.2    Bishop, E.T.3
  • 35
    • 38649085329 scopus 로고    scopus 로고
    • Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine
    • Zhou Q, Kiosses WB, Liu J, et al. Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine. Methods. 2008;44:190-195.
    • (2008) Methods , vol.44 , pp. 190-195
    • Zhou, Q.1    Kiosses, W.B.2    Liu, J.3
  • 36
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1Ymediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R, Hirota K, Fan F, et al. Insulin-like growth factor 1 induces hypoxia-inducible factor 1Ymediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002;277:38205-38211.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3
  • 37
    • 34547937751 scopus 로고    scopus 로고
    • Pancreatic cancer: Is this bleak landscape finally changing?
    • Chicago, IL, USA. June 1-5, JOP. 2007
    • Saif MW. Pancreatic cancer: is this bleak landscape finally changing? Highlights from the 43rd ASCO annual meeting. Chicago, IL, USA. June 1-5, 2007. JOP. 2007;8:365-373.
    • (2007) Highlights from the 43rd ASCO Annual Meeting , vol.8 , pp. 365-373
    • Saif, M.W.1
  • 38
    • 20444410041 scopus 로고    scopus 로고
    • Activation of RalA is critical for ras-induced tumorigenesis of human cells
    • Lim KH, Baines AT, Fiordalisi JJ, et al. Activation of RalA is critical for ras-induced tumorigenesis of human cells. Cancer Cell. 2005;7:533-545.
    • (2005) Cancer Cell , vol.7 , pp. 533-545
    • Lim, K.H.1    Baines, A.T.2    Fiordalisi, J.J.3
  • 39
    • 66449132288 scopus 로고    scopus 로고
    • KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer
    • Yeh JJ, Routh ED, Rubinas T, et al. KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol Cancer Ther. 2009;8:834-843.
    • (2009) Mol Cancer Ther , vol.8 , pp. 834-843
    • Yeh, J.J.1    Routh, E.D.2    Rubinas, T.3
  • 40
    • 0034813635 scopus 로고    scopus 로고
    • Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2
    • Yip-Schneider MT, Lin A, Marshall MS. Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2. Biochem Biophys Res Commun. 2001;280:992-997.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 992-997
    • Yip-Schneider, M.T.1    Lin, A.2    Marshall, M.S.3
  • 41
    • 0037236633 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor
    • Sengupta S, Gherardi E, Sellers LA, et al. Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2003;23:69-75.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 69-75
    • Sengupta, S.1    Gherardi, E.2    Sellers, L.A.3
  • 42
    • 34447108810 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Biology and therapeutic applications
    • Ho QT, Kuo CJ. Vascular endothelial growth factor: Biology and therapeutic applications. Int J Biochem Cell Biol. 2007;39:1349-1357.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1349-1357
    • Ho, Q.T.1    Kuo, C.J.2
  • 43
    • 58149465757 scopus 로고    scopus 로고
    • CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer
    • Matsuo Y, Ochi N, Sawai H, et al. CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer. Int J Cancer. 2009;124:853-861.
    • (2009) Int J Cancer , vol.124 , pp. 853-861
    • Matsuo, Y.1    Ochi, N.2    Sawai, H.3
  • 44
    • 33644975393 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy in pancreatic carcinoma
    • Saif MW. Anti-angiogenesis therapy in pancreatic carcinoma. JOP. 2006;7:163-173.
    • (2006) JOP , vol.7 , pp. 163-173
    • Saif, M.W.1
  • 45
    • 48949092304 scopus 로고    scopus 로고
    • New developments in the treatment of pancreatic cancer
    • Chicago, IL, USA. May 30YJune 3, 2008. JOP
    • Saif MW. New developments in the treatment of pancreatic cancer. Highlights from the 44th ASCO annual meeting. Chicago, IL, USA. May 30YJune 3, 2008. JOP. 2008;9:391-397.
    • (2008) Highlights from the 44th ASCO Annual Meeting , vol.9 , pp. 391-397
    • Saif, M.W.1


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