Glycemic variability in critical illness and the end of Chapter 1

Critical Care Medicine

Volumn 38, Issue 4, 2010, Pages 1206-1208

  Krinsley, James S ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Glucose; Hypoglycemia; Insulin therapy; Intensive care unit; Mortality; Variability

Indexed keywords

GLUCOSE; INSULIN;

CLINICAL PROTOCOL; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIABETES MELLITUS; EDITORIAL; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN INFUSION; INSULIN TREATMENT; INTENSIVE CARE UNIT; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT MONITORING; PREDICTIVE VALIDITY; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 77950269687     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181d3aba5     Document Type: Editorial

References (15)

1. Griesdale DE, de Souza RJ, van Dam RM, et al: Intensive insulin therapy and mortality among critically ill patients: A meta-analysis including NICE-SUGAR study data. CMAJ 2009; 180:821-827
2. Egi M, Bellomo R Stachowski E, et al: Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105:244-252
3. Krinsley JS: Glycemic variability: A strong, independent risk factor for mortality in critically ill patients. Crit Care Med 2008; 36:3008-3013
4. Krinsley JS: Glycemic variability in critically ill patients: Impact of diabetes. J Diab Sci Tech 2009; 3:1292-1301
5. Dossett LA, Cao H, Mowery NT, et al: Blood glucose variability is associated with mortality in the surgical intensive care unit. Am Surg 2008; 74:679-685
6. Ali NA, O'Brien JA, Dungan K, et al: Glucose variability and mortality in patients with sepsis. Crit Care Med 2008; 36:2316-2321
7. Van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-1367
8. Van den Berghe G, Wilmer A, Hermans G, et al: Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354:449-461
9. Meyfroidt G, Keenan DM, Wang X, et al: Dynamic characteristics of blood glucose time series during the course of critical illness: Effects of intensive insulin therapy and relative association with mortality. Crit Care Med 2010; 38:1021-1029
10. Monnier L, Mas E, Ginet C, et al: Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hy-perglycemia in patients with type 2 diabetes. JAMA 2006; 295:1681-1687
11. Krinsley JS, Grover A: Severe hypoglycemia in critically ill patients: Risk factors and outcomes. Crit Care Med 2007; 35:2262-2267
12. Bagshaw S, Egi M, George C, et al: Early blood glucose control and mortality in critically ill patients in Australia. Crit Care Med 2009; 37:463-470
13. Kanji S, Buffie J, Hutton B, et al: Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med 2005; 33:2778-2885
14. The NICE-SUGAR study investigators: Intensive versus conventional insulin therapy in critically ill patients. N Engl J Med 2009; 360:1283-1297
15. Krinsley JS, Preiser JC: Moving beyond tight glycemic control to safe effective glycemic control. Crit Care 2008; 12:149-151