Oncolytic viral therapy for prostate cancer: Efficacy of reovirus as a biological therapeutic

Cancer Research

Volumn 70, Issue 6, 2010, Pages 2435-2444

  Thirukkumaran, Chandini M ^a,b   Nodwell, Michael J ^f   Hirasawa, Kensuke ^g   Shi, Zhong Qiao ^b   Diaz, Roman ^b   Luider, Joanne ^d   Johnston, Randal N ^a   Forsyth, Peter A ^a,b   Magliocco, Anthony M ^a,b,d   Lee, Patrick ^h   Nishikawa, Sandra ^a   Donnelly, Bryan ^a   Coffey, Matt ^e   Trpkov, Kiril ^a,d   Fonseca, Kevin ^c   Spurrell, Jason ^b   Morris, Don G ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b TOM BAKER CANCER CENTRE   (Canada)

^c PROVINCIAL LABORATORY FOR PUBLIC HEALTH   (Canada)

^d CALGARY LABORATORY SERVICES   (Canada)

^e ONCOLYTICS BIOTECH INC   (Canada)

^f Bio Rad Laboratories (Canada) Ltd   (Canada)

^g MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^h DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DNA; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CD8+ T LYMPHOCYTE; CELL DIVISION; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA FRAGMENTATION; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; ONCOLYTIC VIROTHERAPY; PRIORITY JOURNAL; PROGENY; PROSTATE CANCER; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REOVIRUS; TUMOR VOLUME; VIRUS INFECTION; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; MALE; MAMMALIAN ORTHOREOVIRUS 3; MICE; MICE, INBRED NOD; MICE, SCID; ONCOLYTIC VIROTHERAPY; PROSTATIC NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77950230544     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2408     Document Type: Article

References (40)

1. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin 2008;58:71-96.
2. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001;2:533-543
3. Alain T, Hirasawa K, Pon KJ, et al. Reovirus therapy of lymphoid malignancies. Blood 2002;100:4146-4153
4. Hirasawa K, Nishikawa SG, Norman KL, Alain T, Kossakowska A, Lee PW. Oncolytic reovirus against ovarian and colon cancer. Cancer Res 2002;62:1696-1701
5. Norman KL, Coffey MC, Hirasawa K, et al. Reovirus oncolysis of human breast cancer. Hum Gene Ther 2002;13:641-652
6. Himeno Y, Etoh T, Matsumoto T, Ohta M, Nishizono A, Kitano S. Efficacy of oncolytic reovirus against liver metastasis from pancreatic cancer in immunocompetent models. Int J Oncol 2005;27:901-906
7. Wilcox ME, Yang W, Senger , et al. Reovirus as an oncolytic agent against experimental human malignant gliomas. J Natl Cancer Inst 2001;93:903-912
8. Tyler KL. Reoviruses. In: Fields B, editor. Fields Virology. Philadelphia (PA): Lippincott-Raven; 1996, p. 1597-1623
9. Strong JE, Lee PW. The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection. J Virol 1996;70:612-616
10. Strong JE, Coffey MC, Tang D, Sabinin P, Lee PW. The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus. EMBO J 1998;17:3351-3362
11. Coffey MC, Strong JE, Forsyth PA, Lee PW. Reovirus therapy of tumors with activated Ras pathway. Science 1998;282:1332-1334
12. Norman KL, Hirasawa K, Yang AD, Shields MA, Lee PW. Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection. Proc Natl Acad Sci U S A 2004;101:11099-11104
13. Kinkade CW, Castillo-Martin M, Puzio-Kuter A, et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest 2008;18:3051-3064
14. Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008;118:3065-3074
15. Roulston A, Marcellus RC, Branton PE. Viruses and apoptosis. Annu Rev Microbiol 1999;53:577-628.
16. Razvi ES, Welsh RM. Apoptosis in viral infections. Adv Virus Res 1995;45:1-60.
17. Rodgers SE, Barton ES, Oberhaus SM, et al. Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2. J Virol 1997;71:2540-2546
18. Oberhaus SM, Dermody TS, Tyler KL. Apoptosis and the cytopathic effects of reovirus. Curr Top Microbiol Immunol 1998;233:23-49.
19. Debiasi RL, Edelstein CL, Sherry B, Tyler KL. Calpain inhibition protects against virus-induced apoptotic myocardial injury. J Virol 2001;75:351-361
20. Debiasi RL, Squier MK, Pike B, et al. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. J Virol 1999;73:695-701.
21. Connolly JL, Rodgers SE, Clarke P, et al. Reovirus-induced apoptosis requires activation of transcription factor NF-κB. J Virol 2000;74:2981-2989
22. Clarke P, Meintzer SM, Moffitt LA, Tyler KL. Two distinct phases of virus-induced nuclear factor κB regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem 2003;278:18092-18100
23. Clarke P, Meintzer SM, Gibson S, et al. Reovirus-induced apoptosis is mediated by TRAIL. J Virol 2000;74:8135-8139
24. Smith RE, Zweerink HJ, Joklik WK. Polypeptide components of virions, top component and cores of reovirus type 3. Virology 1969;39:791-810.
25. Cejkova S, Rocnova L, Potesil D, et al. Presence of heterozygous ATM deletion may not be critical in the primary response of chronic lymphocytic leukemia cells to fludarabine. Eur J Haematol 2009;82:133-142
26. Jin D, Ojcius DM, Sun D, et al. Leptospira interrogans induces apoptosis in macrophages via caspase-8- and -3-dependent pathways. Infect Immun 2009;77:799-809.
27. Aubry JP, Blaecke A, Lecoanet-Henchoz S, et al. Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity. Cytometry 1999;37:197-204.
28. Koester SK, Roth P, Mikulka WR, Schlossman SF, Zhang C, Bolton WE. Monitoring early cellular responses in apoptosis is aided by the mitochondrial membrane protein-specific monoclonal antibody APO2.7. Cytometry 1997;29:306-312
29. Yang WQ, Lun X, Palmer CA, et al. Efficacy and safety evaluation of human reovirus type 3 in immunocompetent animals: racine and nonhuman primates. Clin Cancer Res 2004;10:8561-8576
30. Morris DG, Forsyth PA, Paterson AH, et al. A phase 1 clinical trial evalutating entralesional REOLYSIN (reovirus) in histologically confirmed malignancies. Proc ASCO 2002:24a.
31. Spurrell JC, Shi ZQ, Kim A, Morris DG. Reovirus as an Immunotherapeutic adjuvant. Canadian Prostate Cancer Research Foundation Annual Meeting. 2007, Abstr.
32. Hirasawa K, Nishikawa SG, Norman KL, et al. Systemic reovirus therapy of metastatic cancer in immune-competent mice. Cancer Res 2003;63:348-353
33. White CL, Twigger KR, Vidal L, et al. Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial. Gene Ther 2008;15:911-920.
34. Vidal L, Twigger K, White CL, et al. Phase I trial of intratumoral administration of reovirus type 3 (REOLYSIN) in combination with radiation in patients with advanced malignancies. Clin Res 2008;13:Abstr.
35. Twigger K, Vidal L, White CL, et al. Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy. Clin Cancer Res 2008;14:912-923
36. Douville RN, Su RC, Coombs KM, Simons FE, Hayglass KT. Reovirus serotypes elicit distinctive patterns of recall immunity in humans. J Virol 2008;82:7515-7523
37. Talmadge JE, Donkor M, Scholar E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev 2007;26:373-400.
38. Yu P, Fu YX. Tumor-infiltrating T lymphocytes: friends or foes. Lab Invest 2006;86:231-245.
39. Hamamdzic D, Phillips-Dorsett T, Altman-Hamamdzic S, London SD, London L. Reovirus triggers cell type-specific proinflamatory responses dependent on the autocrine action of IFN-β. Am J Physiol Lung Cell Mol Physiol 2001;280:L18-29.
40. Kilani RT, Tamimi Y, Hanel EG, et al. Selective reovirus killing of bladder cancer in a co-culture spheroid model. Virus Res 2003;93:1-12.