The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 3, 2010, Pages 310-314

  Hasegawa, Yoshitaka ^a   Kishimoto, Shuichi ^a   Shibatani, Naoki ^a   Nomura, Hiromichi ^a   Ishii, Yuko ^a   Onishi, Mika ^a   Inotsume, Nobuo ^b   Takeuchi, Yoshikazu ^a   Fukushima, Shoji ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Diabetes; Morphine; Morphine 3 glucuronide; Pharmacokinetics; Transporter

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2B1; MESSENGER RNA; MORPHINE; MORPHINE 3 GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG TRANSPORT; DRUG URINE LEVEL; GENE EXPRESSION; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

ANALGESICS, OPIOID; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HALF-LIFE; LIVER; MALE; MORPHINE; MORPHINE DERIVATIVES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 77950209253     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.62.03.0004     Document Type: Article

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