The role of vitamin D in regulating immune responses

Israel Medical Association Journal

Volumn 12, Issue 3, 2010, Pages 174-175

  Toubi, Elias ^a   Shoenfeld, Yehuda ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Autoimmunity; T regulatory cells; Vitamin D

Indexed keywords

CALCIPOTRIOL; GAMMA INTERFERON; HYDROXYCHLOROQUINE; INTERLEUKIN 10; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; VITAMIN D; VITAMIN D RECEPTOR;

ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; AUTOIMMUNE DISEASE; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE SEVERITY; EDITORIAL; HUMAN; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOTHERAPY; INFLAMMATION; NONHUMAN; REGULATORY T LYMPHOCYTE; SYSTEMIC LUPUS ERYTHEMATOSUS; VITAMIN D DEFICIENCY;

AUTOIMMUNE DISEASES; CALCITRIOL; DENDRITIC CELLS; DIETARY SUPPLEMENTS; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOTHERAPY; INTERFERON-GAMMA; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 9; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 77950146782     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (18)

1. Daudi N, Karmali R, Fuss M. Evaluation of vitamin D deficiency in hospitalized patients in Brussels. Rev Med Brux 2009; 30: 5-10.
2. Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009; 169: 626-32.
3. Albert PJ, Proal AD, Marshall TG. Vitamin D: the alternative hypothesis. Autoimmun Rev 2009; 8: 639-44.
4. Adorini L, Penna G. Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 2009; 70: 345-52.
5. Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis 2007; 66: 1137-42.
6. Tang J, Zhou R, Luger D, et al. Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector responses. J Immunol 2009; 182: 4624-32.
7. Smolders J, Peelen E, Thewissen M, et al. The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev 2009; 8: 621-6.
8. Cutolo M, Otsa K, Uprus M, Paolino S, Seriolo B. Vitamin D in rheumatoid arthritis. Autoimmun Rev 2007; 7: 59-64.
9. Doria A, Arienti S, Rampudda M, Canova M, Tonon M, Sarzi-Puttini P. Preventive strategies in systemic lupus erythematosus. Autoimmun Rev 2008; 7: 192-7.
10. Kamen DL, Cooper GS, Bouali H, Shaftman SR, Hollis BW, Gilkeson GS. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006; 5: 114-17.
11. Carvalho JF, Blank M, Kiss E, Tarr T, Amital H, Shoenfeld Y. Anti-vitamin D, vitamin D, in SLE: preliminary results. Ann N Y Acad Sci 2007; 1109: 550-7.
12. Borba VZ, Vieira JG, Kasamatsu T, Radominski SC, Sato EI, Lazaretti-Castro M. Vitamin D deficiency in patients with active systemic lupus erythematosus. Osteoporos Int 2009; 20(3): 427-33.
13. Kamen D, Aranow C. Vitamin D in systemic lupus erythematosus. Curr Opin Rheumatol 2008; 20: 532-7.
14. Ruiz-Irastorza G, Egurbide MV, Olivares N, Martinez-Berriotxoa A, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford) 2008; 47: 920-3.
15. Prietl B, Pilz S, Wolf M, Tomaschitz A, Obermayer-Pietsch B, Graninger B, Pieber TR. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? IMAJ Isr Med Assoc J 2010; 12: 136-9.
16. Taher YA, van Esch BC, Hofman GA, Henricks PAJ, van Oosterhout AJ. 1α25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-β. J Immunol 2008; 180: 5211-21.
17. Urry Z, Xystrakis E, Richards DF, et al. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1α25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest 2009; 119: 387-98.
18. Ghoreishi M, Bach P, Obst J, Komba M, Fleet JC, Dutz JP. Expansion of antigen-specific regulatory T cells with the topical vitamin D analog calcipotriol. J Immunol 2009; 15: 6071-8.