Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity

Human Reproduction

Volumn 25, Issue 4, 2010, Pages 874-883

  Meng, C X ^a   Marions, L ^a   Bystrom B ^a   Gemzell Danielsson, K ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Emergency contraception; Endometrial receptivity markers; Levonorgestrel; Oral route; Vaginal route

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR; LEVONORGESTREL; LUTEINIZING HORMONE; MESSENGER RNA; MUCIN 1; NORGESTREL; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; STEROID RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VITRONECTIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EMERGENCY CONTRACEPTION; ENDOMETRIUM; ENDOMETRIUM BIOPSY; ENDOMETRIUM CELL; FEMALE; FERTILITY; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MENSTRUAL CYCLE; NUCLEOTIDE SEQUENCE; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; UTERUS;

EID: 77950133171     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deq007     Document Type: Article

References (59)

1. Achache H, Revel A. Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update 2006;6:731-746.
2. Aghajanova L, Stavreus-Evers A, Nikas Y, Hovatta O, Landgren BM. Coexpression of pinopodes and leukemia inhibitory factor, as well as its receptor, in human endometrium. Fertil Steril 2003;79 (Suppl. 1): 808-814.
3. Arici A, Engin O, Attar E, Olive DL. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. J Clin Endocrinol Metab 1995;6:1908-1915.
4. Arowojolu AO, Okewole IA, Adekunle AO. Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians. Contraception 2002;4:269-273.
5. Auernhammer CJ, Melmed S. Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr Rev 2000;3:313-345.
6. Bischof P, Haenggeli L, Campana A. Effect of leukemia inhibitory factor on human cytotrophoblast differentiation along the invasive pathway. Am J Reprod Immunol 1995;4:225-230.
7. Brache V, Croxatto H, Sitruk-Ware R, Maguire R, Montero JC, Kumar N, Salvatierra AM, Tejada AS, Cochon L, Forcelledo ML et al. Effect of a single vaginal administration of levonorgestrel in Carraguard gel on the ovulatory process: a potential candidate for 'dual protection' emergency contraception. Contraception 2007;2:111-116.
8. Brinsden PR, AlamV,deMoustierB,EngrandP.Recombinant human leukemia inhibitory factor does not improve implantation and pregnancy outcomes after assisted reproductive techniques in women with recurrent unexplained implantation failure. Fertil Steril 2009;4:1445-1447.
9. Cameron ST, Critchley HO, Buckley CH, Kelly RW, Baird DT. Effect of two antiprogestins (mifepristone and onapristone) on endometrial factors of potential importance for implantation. Fertil Steril 1997;6:1046-1053.
10. Catalano RD, Critchley HO, Heikinheimo O, Baird DT, Hapangama D, Sherwin JR, Charnock-Jones DS, Smith SK, Sharkey AM. Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod 2007;9:641-654.
11. Charnock-Jones DS, Sharkey AM, Fenwick P, Smith SK. Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time. J Reprod Fertil 1994;2:421-426.
12. Cheng L, Gulmezoglu AM, Piaggio G, Ezcurra E, Van Look PF. Interventions for emergency contraception. Cochrane Database Syst Rev 2008;2:CD001324.
13. Cox B, Kislinger T, Emili A. Integrating gene and protein expression data: pattern analysis and profile mining. Methods 2005;3:303-314.
14. Cullinan EB, Abbondanzo SJ, Anderson PS, Pollard JW, Lessey BA, Stewart CL. Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation. Proc Natl Acad Sci USA 1996;7:3115-3120.
15. Danielsson KG, Swahn ML, Bygdeman M. The effect of various doses of mifepristone on endometrial leukaemia inhibitory factor expression in the midluteal phase\an immunohistochemical study. Hum Reprod 1997;6:1293-1297.
16. Devoto L, Fuentes A, Palomino A, Espinoza A, Kohen P, Ranta S, von Hertzen H. Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5-mg dose by the oral and vaginal route. Fertil Steril 2005;1:46-51.
17. Dimitriadis E, White CA, Jones RL, Salamonsen LA. Cytokines, chemokines and growth factors in endometrium related to implantation. Hum Reprod Update 2005;6:613-630.
18. Durand M, del Carmen Cravioto M, Raymond EG, Duran-Sanchez O, De la Luz Cruz-Hinojosa M, Castell-Rodriguez A, Schiavon R, Larrea F. On the mechanisms of action of short-term levonorgestrel administration in emergency contraception. Contraception 2001;4:227-234.
19. Gemzell-Danielsson K, Marions L. Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception. Hum Reprod Update 2004;4:341-348.
20. Guttinger A, Critchley HO. Endometrial effects of intrauterine levonorgestrel. Contraception 2007;6:S93-S98.
21. Hack CJ. Integrated transcriptome and proteome data: the challenges ahead. Brief Funct Genomic Proteomic 2004;3:212-219.
22. Haines BP, Voyle RB, Rathjen PD. Intracellular and extracellular leukemia inhibitory factor proteins have different cellular activities that are mediated by distinct protein motifs. Mol Biol Cell 2000;4:1369-1383.
23. Hamoda H, Ashok PW, Stalder C, Flett GM, Kennedy E, Templeton A. A randomized trial of mifepristone (10 mg) and levonorgestrel for emergency contraception. Obstet Gynecol 2004;6:1307-1313.
24. Harper MJ. The implantation window. Baillieres Clin Obstet Gynaecol 1992; 2:351-371.
25. Ho PC, Kwan MS. A prospective randomized comparison of levonorgestrel with the Yuzpe regimen in post-coital contraception. Hum Reprod 1993;3:389-392.
26. Horne AW, Lalani EN, Margara RA, White JO. The effects of sex steroid hormones and interleukin-1-beta on MUC1 expression in endometrial epithelial cell lines. Reproduction 2006;4:733-742.
27. Ilesanmi AO, Hawkins DA, Lessey BA. Immunohistochemical markers of uterine receptivity in the human endometrium. Microsc Res Tech 1993; 3:208-222.
28. Kloosterboer HJ, Vonk-Noordegraaf CA, Turpijn EW. Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. Contraception 1988;3:325-332.
29. Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Inoue T, Horie K, Nakayama H, Fujita J, Mori T. Expression of leukemia inhibitory factor in human endometrium and placenta. Biol Reprod 1994;4:882-887.
30. Lalitkumar PG, Sengupta J, Ghosh D. Endometrial tumor necrosis factor alpha (TNFalpha) is a likely mediator of early luteal phase mifepristone- mediated negative effector action on the preimplantation embryo. Reproduction 2005;3:323-335.
31. Lalitkumar PG, Lalitkumar S, Meng CX, Stavreus-Evers A, Hambiliki F, Bentin-Ley U, Gemzell-Danielsson K. Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model. Hum Reprod 2007; 11:3031-3037.
32. Landgren BM, Johannisson E, Aedo AR, Kumar A, Shi YE. The effect of levonorgestrel administered in large doses at different stages of the cycle on ovarian function and endometrial morphology. Contraception 1989;3:275-289.
33. Lemus AE, Vilchis F, Damsky R, Chavez BA, Garcia GA, Grillasca I, Perez-Palacios G. Mechanism of action of levonorgestrel: in vitro metabolism and specific interactions with steroid receptors in target organs. J Steroid Biochem Mol Biol 1992;3-8:881-890.
34. Lessey BA, Killam AP, Metzger DA, Haney AF, Greene GL, McCarty KS Jr. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 1988;2:334-340.
35. Marions L, Danielsson KG. Expression of cyclo-oxygenase in human endometrium during the implantation period. Mol Hum Reprod 1999; 10:961-965.
36. Marions L, Hultenby K, Lindell I, Sun X, Stabi B, Gemzell Danielsson K. Emergency contraception with mifepristone and levonorgestrel: mechanism of action. Obstet Gynecol 2002;1:65-71.
37. Marions L, Cekan SZ, Bygdeman M, Gemzell-Danielsson K. Effect of emergency contraception with levonorgestrel or mifepristone on ovarian function. Contraception 2004;5:373-377.
38. Meng CX, Andersson KL, Bentin-Ley U, Gemzell-Danielsson K, Lalitkumar PG. Effect of levonorgestrel and mifepristone on endometrial receptivity markers in a three-dimensional human endometrial cell culture model. Fertil Steril 2009;1:256-264.
39. Mor E, Saadat P, Kives S, White E, Reid RL, Paulson RJ, Stanczyk FZ. Comparison of vaginal and oral administration of emergency contraception. Fertil Steril 2005;1:40-45.
40. Muller AL, Llados CM, Croxatto HB. Postcoital treatment with levonorgestrel does not disrupt postfertilization events in the rat. Contraception 2003;5:415-419.
41. Mylonas I, Jeschke U, Shabani N, Kuhn C, Balle A, Kriegel S, Kupka MS, Friese K. Immunohistochemical analysis of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in normal human endometrium. Acta Histochem 2004;3:245-252.
42. Novikova N, Weisberg E, Stanczyk FZ, Croxatto HB, Fraser IS. Effectiveness of levonorgestrel emergency contraception given before or after ovulation\a pilot study. Contraception 2007;2: 112-118.
43. Ortiz ME, Ortiz RE, Fuentes MA, Parraguez VH, Croxatto HB. Post-coital administration of levonorgestrel does not interfere with post-fertilization events in the new-world monkey Cebus apella. Hum Reprod 2004; 6:1352-1356.
44. Palomino WA, Kohen P, Devoto L. A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expression of the L-selectin ligand or molecular markers of endometrial receptivity. Gynecol Endocrinol 2009 December 22. [Epub ahead of print].
45. Rodrigues I, Grou F, Joly J. Effectiveness of emergency contraceptive pills between 72 and 120 hours after unprotected sexual intercourse. Am J Obstet Gynecol 2001;4:531-537.
46. Rosario G, Sachdeva G, Okulicz WC, Ace CI, Katkam RR, Puri CP. Role of progesterone in structural and biochemical remodeling of endometrium. Front Biosci 2003;8:s924-s935.
47. Sachdeva G, Patil V, Katkam RR, Manjramkar DD, Kholkute SD, Puri CP. Expression profiles of endometrial leukemia inhibitory factor, transforming growth factor beta2 (TGFbeta2), and TGFbeta2 receptor in infertile bonnet monkeys. Biol Reprod 2001;1:1-8.
48. Sitruk-Ware R, Brache V, Maguire R, Croxatto H, Kumar N, Kumar S, Montero JC, Salvatierra AM, Phillips D, Faundes A. Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for 'dual protection' contraception. Contraception 2007;6:454-460.
49. Snijders MP, de Goeij AF, Debets-Te Baerts MJ, Rousch MJ, Koudstaal J, Bosman FT. Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause. J Reprod Fertil 1992; 94:363-371.
50. Spona J, Matt K, Schneider WH. Study on the action of D-norgestrel as a postcoital contraceptive agent. Contraception 1975;1:31-43.
51. Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F, Abbondanzo SJ. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992;6390: 76-79.
52. Terenius L. Affinities of progestogen and estrogen receptors in rabbit uterus for synthetic progestogens. Steroids 1974;6:909-919.
53. Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB. Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 1993;10: 1256-1265.
54. van der Gaast MH, Macklon NS, Beier-Hellwig K, Krusche CA, Fauser BC, Beier HM, Classen-Linke I. The feasibility of a less invasive method to assess endometrial maturation-comparison of simultaneously obtained uterine secretion and tissue biopsy. BJOG 2009;2:304-312.
55. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002;7: RESEARCH0034.
56. Vogiagis D, Marsh MM, Fry RC, Salamonsen LA. Leukaemia inhibitory factor in human endometrium throughout the menstrual cycle. J Endocrinol 1996;1:95-102.
57. von Hertzen H, Piaggio G, Ding J, Chen J, Song S, Bartfai G, Ng E, Gemzell-Danielsson K, Oyunbileg A, Wu S et al. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomised trial. Lancet 2002; 9348:1803-1810
58. WHO. Task Force on Postovulatory Methods of Fertility Regulation. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet 1998;9126:428-433.
59. Wilcox AJ, Baird DD, Weinberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 1999;23:1796-1799.