Mutant APH(2″)-IIa enzymes with increased activity against amikacin and isepamicin

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 4, 2010, Pages 1590-1595

  Toth, Marta ^a   Frase, Hilary ^a   Chow, Joseph W ^b   Smith, Clyde ^c   Vakulenko, Sergei B ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE 2'' PHOSPHOTRANSFERASE IIA; DIBEKACIN; GENTAMICIN; ISEPAMICIN; KANAMYCIN; MUTANT PROTEIN; NETILMICIN; PHOSPHOTRANSFERASE; SISOMICIN; TOBRAMYCIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

AGED; AMIKACIN; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DIRECTED MOLECULAR EVOLUTION; DNA PRIMERS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENTAMICINS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 77950108480     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01444-09     Document Type: Article

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