Derivatives of schisandrin with increased inhibitory potential on prostaglandin E2 and leukotriene B4 formation in vitro

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2809-2815

  Blunder, Martina ^a   Pferschy Wenzig, Eva M ^a   Fabian, Walter M F ^b   Hüfner, Antje ^a   Kunert, Olaf ^a   Saf, Robert ^c   Schühly, Wolfgang ^a   Bauer, Rudolf ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Cyclooxygenase; Demethylation; Derivatives; Lipoxygenase; Ring contraction; Schisandra chinensis lignans; Schisandrin

Indexed keywords

6 (1' IODOETHYL) 1,2,3,9,10,11 HEXAMETHOXY 6 METHYL 5H DIBENZO[A,C]CYCLOHEPTENE; 6,7 DIHYDRO 6 (1' HYDROXYETHYL) 3,9 DIMETHOXY 6 METHYL 5H DIBENZO[A,C]CYCLOHEPTENE 1,2,10,11 TETRAOL; 6,7 DIHYDRO 6 (1' HYDROXYETHYL) 6 METHYL 5H DIBENZO[A,C]CYCLOHEPTENE 1,2,3,9,10,11 HEXAOL; BIPHENYL DERIVATIVE; CYCLOALKENE; CYCLOOXYGENASE 2; LEUKOTRIENE B4; NATURAL PRODUCT; PROSTAGLANDIN E2; SCHISANDRIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; CHIRALITY; CIRCULAR DICHROISM; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SCHISANDRA CHINENSIS; SCHISANDRACEAE;

ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; CIRCULAR DICHROISM; CYCLOOCTANES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; INDICATORS AND REAGENTS; LEUKOTRIENE B4; LIGNANS; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; POLYCYCLIC COMPOUNDS; SCHISANDRA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

SCHISANDRA CHINENSIS;

EID: 77950051070     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.031     Document Type: Article

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