Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2512-2515

  Vera, Matthew D ^a   Lundquist IV, Joseph T ^a   Chengalvala, Murty V ^a   Cottom, Joshua E ^a   Feingold, Irene B ^a   Garrick, Lloyd M ^a   Green, Daniel M ^a   Hauze, Diane B ^a   Mann, Charles W ^a   Mehlmann, John F ^a   Rogers, John F ^a   Shanno, Linda ^a   Wrobel, Jay E ^a   Pelletier, Jeffrey C ^a  

^a PFIZER INC   (United States)

Author keywords

GnRH; GnRH antagonist; Gonadotropin releasing hormone; Gonadotropin releasing hormone antagonist; GPCR

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; BENZOXAZOLE DERIVATIVE; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; HETEROCYCLIC COMPOUND; IMIDAZOPYRIDINE DERIVATIVE; PIPERAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CELLS, CULTURED; HALF-LIFE; HETEROCYCLIC COMPOUNDS; HUMANS; MALE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LHRH;

RATTUS;

EID: 77950043902     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.099     Document Type: Article

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