Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure-activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1986-1990

  Hauze, Diane B ^a   Chengalvala, Murty V ^a   Cottom, Joshua E ^a   Feingold, Irene B ^a   Garrick, Lloyd ^a   Green, Daniel M ^a   Huselton, Christine ^a   Kao, Wenling ^a   Kees, Kenneth ^a   Lundquist IV, Joseph T ^a   Mann, Charles W ^a   Mehlmann, John F ^a   Rogers, John F ^a   Shanno, Linda ^a   Wrobel, Jay ^a   Pelletier, Jeffrey C ^a  

^a PFIZER INC   (United States)

Author keywords

2 Phenyl 4 piperazinyl benzimidazole; Gonadotropin releasing hormone (GnRH) receptor

Indexed keywords

2 PHENYL 4 PIPERAZINYLBENZIMIDAZOLE; BENZENE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GONADORELIN ANTAGONIST; GONADORELIN RECEPTOR; HETEROCYCLIC COMPOUND; LUTEINIZING HORMONE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG RECEPTOR BINDING; IC 50; IN VITRO STUDY; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; ORCHIECTOMY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZIMIDAZOLES; HETEROCYCLIC COMPOUNDS; LUTEINIZING HORMONE; MODELS, ANIMAL; PIPERAZINES; RATS; RECEPTORS, LHRH; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 61849090425     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.043     Document Type: Article

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