High concentration of magnolol induces hepatotoxicity under serum-reduced conditions

Phytomedicine

Volumn 17, Issue 6, 2010, Pages 469-474

  Kao, Ying Hsien ^a   Jawan, Bruno ^a   Sun, Cheuk Kwan ^a   Goto, Shigeru ^a,b   Lin, Yu Chun ^a   Hung, Chun Tzu ^a   Pan, Mei Chun ^a   Hsu, Li Wen ^a   Cheng, Yu Fan ^a   Lai, Chia Yun ^b   Wang, Chih Shien ^a   Tsai, Ching Chou ^a   Chang, Huoy Rou ^c   Chen, Chao Long ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b Iwao Hospital   (Japan)

^c I SHOU UNIVERSITY   (Taiwan)

Author keywords

Caspase 3 inhibitor; Cold preservation injury; Cytochrome c; Hepatotoxicity; Liver graft; Magnolia officinalis; Magnolol

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CYTOCHROME C; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; MAGNOLOL; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; BIPHENYL DERIVATIVE; I KAPPA B; LIGNAN; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GRAFT PRESERVATION; LIVER CELL; LIVER GRAFT; LIVER TOXICITY; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BARK; CHEMISTRY; COLD; CRYOPRESERVATION; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; LIVER TRANSPLANTATION; MAGNOLIA; METABOLISM; MITOCHONDRION; REPERFUSION INJURY; SERUM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TOXICITY; TUNEL ASSAY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIPHENYL COMPOUNDS; BLOTTING, WESTERN; CASPASE 3; COLD TEMPERATURE; CRYOPRESERVATION; CYTOCHROMES C; DRUG-INDUCED LIVER INJURY; I-KAPPA B PROTEINS; IN SITU NICK-END LABELING; LIGNANS; LIVER; LIVER TRANSPLANTATION; MAGNOLIA; MALE; MITOCHONDRIA; NF-KAPPA B; PLANT BARK; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERUM; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MAGNOLIA OFFICINALIS;

EID: 77950022238     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.07.012     Document Type: Article

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