Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness

Mathematics and Computers in Simulation

Volumn 40, Issue 3-4, 1996, Pages 453-480

  Hameroff, Stuart ^a   Penrose, Roger ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Consciousness; Cytoskeleton; Microtubules; Quantum gravity; Quantum theory

Indexed keywords

BRAIN; CALCULATIONS; CONFORMATIONS; NEUROLOGY; PROBABILITY; QUANTUM OPTICS; QUANTUM THEORY; WAVEFORM ANALYSIS;

BRAIN MICROTUBULES; CONSCIOUSNESS; INTERNAL QUANTUM EVENTS; MICROTUBULE ASSOCIATED PROTEINS; NEUROSCIENCE; QUANTUM COHERENCE; QUANTUM OSCILLATIONS; QUANTUM WAVE FUNCTION; SPACE TIME GEOMETRIES;

MATHEMATICAL MODELS;

EID: 0030121458     PISSN: 03784754     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-4754(96)80476-9     Document Type: Article

References (98)

1. Y. Aharonov and L. Vaidman, Properties of a quantum system during the time interval between two measurements, Phys. Rev. A. 41 (1990) 11.
2. L.A. Amos and A. Klug, Arrangement of subunits in flagellar microtubules, J. Cell Sci. 14 (1974) 523-550.
3. J.M. Andreu, Hydrophobic interaction of tubulin, Ann. NY Acad. Sci. 466 (1986) 626-630.
4. 1 monophosphate-simulatable phosphorylation of cat visual cortex proteins, particularly of microtubule-associate protein 2 (MAP2): Effects of normal and dark rearing and of the exposure to light, J. Neurosci. 5 (1985) 2465-2483.
5. J. Atema, Microtubule theory of sensory transduction, J. Theor. Biol. 38 (1973) 181-190.
6. H. Athenstaedt, Pyroelectric and piezoelectric properties of vertebrates, Ann. NY Acad. Sci. 238 (1974) 68-93.
7. B.J. Baars, A Cognitive Theory of Consciousness (Cambridge University Press, Cambridge, 1988).
8. B.J. Baars, How does a serial, integrated and very limited stream of consciousness emerge from a nervous system that is mostly unconscious, distributed, parallel and of enormous capacity?, in: Experimental and Theoretical Studies of Consciousness, Ciba Foundation Symposium, Vol. 174 (Wiley, Chichester, UK, 1993) 282-303.
9. F. Beck and J.C. Eccles, Quantum aspects of brain activity and the role of consciousness, Proc. Nat. Acad. Sci. USA 89 (23) (1992) 11357-11361.
10. P. Benioff, Quantum mechanical Hamiltonian models of Turing machines, J. Stat. Phys. 29 (1982) 515-546.
11. G. Bensimon and R. Chernat, Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats, Pharmacol. Biochem. Behavior 38 (1991) 141-145.
12. D. Bigot and S.P. Hunt, Effect of excitatory amino acids on microtubule-associated proteins in cultured cortical and spinal neurons, Neurosci. Lett. 111 (1990) 275-280.
13. R.B. Burns, Spatial organization of the microtubule associated proteins of reassembled brain microtubules, J. Ultrastruct. Res. 65 (1978) 73-82.
14. H.F. Cantiello, J.L. Stow, A.G. Prat and D.A. Ausiello, Actin filaments regulate Na+ channel activity, Am. J. Physiol. 265(5 pt 1) (1991) C882-C888.
15. K.-C. Chou, C.-T. Zhang and G.M. Maggiora, Solitary wave dynamics as a mechanism for explaining the internal motion during microtubule growth, Biopolymers 34 (1994) 143-153.
16. C. Cianci, D. Graff, B. Gao and R.C. Weisenberg, ATP-dependent gelation-contraction of microtubules in vitro, Ann. NY Acad. Sci. 466 (1986) 656-659.
17. J.S. Clegg, Intracellular water, metabolism and cell architecture, in: H. Fröhlich and F. Kremer, eds., Coherent Excitations in Biological Systems (Springer, Berlin, 1983).
18. F.H.C. Crick, Function of the thalamic reticular complex: The searchlight hypothesis, Proc. Nat. Acad. Sci. USA 81 (1984) 4586-4593.
19. F. Crick and C. Koch, Towards a neurobiological theory of consciousness, Seminars in the Neurosciences 2 (1990) 263-275.
20. J. Cronley-Dillon, D. Carden and C. Birks, The possible involvement of brain microtubules in memory fixation, J. Exp. Biol. 61 (1974) 443-454.
21. J.E. Dayhoff, S. Hameroff, R. Lahoz-Beltra and C.E. Swenberg, Cytoskeletal involvement in neuronal learning: A review, Eur. Biophys. J. 23 (1994) 79-93.
22. M. De Brabander, A model for the microtubule organizing activity of the centrosomes and kinetochores in mammalian cells, Cell Biol. Intern. Rep. 6 (1982) 901-915.
23. L. Decke, B. Grotzinger and H.H. Kornhuber, Voluntary finger movement in man: Cerebral potentials and theory, Biol. Cybernetics 23 (1976) 99.
24. E. Del Giudice, S. Doglia and M. Milani, Self-focusing and ponderomotive forces of coherent electric waves: A mechanisim for cytoskeleton formation and dynamics, in: H. Fröhlich and F. Kremer, eds., Coherent Excitations in Biological Systems (Springer, Berlin, 1983) 123-127.
25. D. Deutsch, Quantum theory, the Church-Turing principle and the universal quantum computer, Proc. Roy. Soc. London Ser. A 400 (1985) 97-117.
26. D. Deutsch and R. Josza, Rapid solution of problems by quantum computation, Proc. Roy. Soc. London Ser. A 439 (1992) 553-556.
27. L. Diósi, Models for universal reduction of macroscopic quantum fluctuations, Phys. Rev. A. 40 (1989) 1165-1174.
28. P. Dustin, Microtubules, 2nd Revised Edition (Springer, Berlin, 1984).
29. J.C. Eccles, Evolution of consciousness, Proc. Nat. Acad. Sci. 89 (1992) 7320-7324.
30. G. Edelman, The Remembered Present: A Biological Theory of Consciousness (Basic Books, New York, 1989).
31. Y. Engelborghs, Dynamic aspects of the conformational states of tubulin and microtubules, Nanobiology 1 (1992) 97-105.
32. R.P. Feynman, Quantum mechanical computers, Found. Phys. 16 (6) (1986) 507-531.
33. W.J. Freeman, Mass Action in the Nervous System (Academic Press, New York, 1975).
34. W.J. Freeman, Spatial properties of an EEG event in the olfactory bulb and cortex, Electroencephalogr. and Clin. Neurophysiol. 44 (1978) 586-605.
35. P. Friedrich, Protein structure: The primary substrate for memory, Neurosci. 35 (1990) 1-7.
36. H. Fröhlich, Long-range coherence and energy storage in biological systems. Int. J. Quantum Chem. 2 (1968) 641-649.
37. H. Fröhlich, Long range coherence and the actions of enzymes, Nature 228 (1970) 1093.
38. H. Fröhlich, The extraordinary dielectric properties of biological materials and the action of enzymes, Proc. Nat. Acad. Sci. 72 (1975) 4211-4215.
39. L. Genberg, L. Richard, G. McLendon and R.J. Dwayne-Miller, Direct observation of global protein motion in hemoglobin and myoglobin on picosecond time scales, Science 251 (1991) 1051-1054.
40. L. Genzel, F. Kremer, A. Poglitsch and G. Bechtold, Relaxation processes on a picosecond time scale in hemoglobin and poly observed by millimeter-wave spectroscopy, Biopolymers 22 (1983) 1715-1729.
41. R. Geroch and J.B. Hartle, Computability and physical theories, Found. Phys. 16 (1986) 533.
42. G.C. Ghirardi, R. Grassi and A. Rimini, Continuous-spontaneous reduction model involving gravity, Phys. Rev. A. 42 (1990) 1057-1064.
43. G.C. Ghirardi, A. Rimini and T. Weber, Unified dynamics for microscopic and macroscopic systems, Phys. Rev. D. 34 (1986) 470.
44. J.M. Gilbert and P. Strocchi, In vitro studies of the biosynthesis of brain tubulin, Ann. NY Acad. Sci. 466 (1986) 89-102.
45. C.M. Gray and W. Singer, Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex, Proc. Nat. Acad. Sci. USA 86 (1989) 1698-1702.
46. W. Grey-Walter, The Living Brain (Gerald Duckworth and Co., Ltd, 1953).
47. W. Grundler and F. Keilmann, Sharp resonances in yeast growth prove nonthermal sensitivity to microwaves, Phys. Rev. Lett. 51 (1983) 1214-1216.
48. S. Halpain and P. Greengard, Activation of NMDA receptors induces rapid dephosphorylation of the cytoskeletal protein MAP2, Neuron 5, 237-246.
49. S.R. Hameroff, Ultimate Computing: Biomolecular Consciousness and Nanotechnology (North-Holland, Amsterdam, 1987).
50. S.R. Hameroff, J.E. Dayhoff, R. Lahoz-Beltra, A. Samsonovich and S. Rasmussen, Conformational automata in the cytoskeleton: Models for molecular computation, IEEE Comput. (1992) 30-39.
51. S.R. Hameroff, S.A. Smith and R.C. Watt, Nonlinear electrodynamics in cytoskeletal protein lattices, in: W.R. Adey and A.F. Lawrence, eds., Nonlinear Electrodynamics in Biological Systems (Plenum, New York, 1984).
52. S.R. Hameroff and R.C. Watt, Information processing in microtubules, J. Theor. Biol. 98 (1982) 549-561.
53. D.O. Hebb, The Organization of Behavior (Wiley, New York, 1949).
54. D.O. Hebb, Essay on Mind (Lawrence Erlbaum Associates, Hillsdale, NJ, 1980).
55. N. Hirokawa, Molecular architecture and dynamics of the neuronal cytoskeleton, in: R.D. Burgoyne, ed., The Neuronal Cytoskeleton (Wiley-Liss, New York, 1991) 5-74.
56. M. Jibu, S. Hagan, S.R. Hameroff, K.H. Pribram and K. Yasue, Quantum optical coherence in cytoskeletal microtubules: Implications for brain function, BioSystems 32 (1994) 195-209.
57. A. Kaivarainen, Personal communication, 1994.
58. F. Károlházy, A. Frenkel and B. Lukacs, On the possible role of gravity on the reduction of the wave function, in : R. Penrose and C.J. Isham, eds., Quantum Concepts in Space and Time (Oxford University Press, Oxford, 1986).
59. M. Karplus and J.A. McCammon, Protein ion channels, gates, receptors, in: J. King, ed., Dynamics of Proteins: Elements and Function, Ann. Rev. Biochem. (Benjamin/Cummings, Menlo Park, 1983) 263-300.
60. H. Kim, C.G. Jensen and L.I. Rebhund, The binding of MAP2 and tau on brain microtubules in vitro, in: D. Soifer, ed., Dynamic Aspects of Microtubule Biology (1986) 218-239; Ann. NY Acad. Sci. 466.
61. H. Kim, C.G. Jensen and L.I. Rebhund, The binding of MAP2 and tau on brain microtubules in vitro, in: D. Soifer, ed., Dynamic Aspects of Microtubule Biology (1986) 218-239; Ann. NY Acad. Sci. 466.
62. M. Kirschner and T. Mitchison, Beyond self assembly: From microtubules to morphogenesis, Cell 45 (1986) 329-342.
63. T. Kudo, K. Tada, M. Takeda and T. Nishimura, Learning impairment and microtubule-associated protein 2 (MAP2) decrease in gerbils under chronic cerebral hypoperfusion, Stroke 21 (1990) 1205-1209.
64. J.C. Lee, D.J. Field, H.J. George and J. Head, Biochemical and chemical properties of tubulin subspecies, Ann. NY Acad. Sci. 466 (1986) 111-128.
65. B. Libet, Cerebral processes that distinguish conscious experience from unconscious mental functions, in: J.C. Eccles and O.D. Creutzfeld, eds., The Principles of Design and Operation of the Brain (Springer, Berlin, 1990) 185-205; Experimental Brain Research Series 21.
66. B. Libet, Cerebral processes that distinguish conscious experience from unconscious mental functions, in: J.C. Eccles and O.D. Creutzfeld, eds., The Principles of Design and Operation of the Brain (Springer, Berlin, 1990) 185-205; Experimental Brain Research Series 21.
67. B. Libet, E.W. Wright, Jr., B. Feinstein and D.K. Pearl, Subjective referral of the timing for a conscious sensory experience, Brain 102 (1979) 193-224.
68. E. Mandelkow and E.-M. Mandelkow, Microtubule structure, Curr. Opinions Structural Biology 4 (1994) 171-179.
69. E.-M. Mandelkow and E. Mandelkow, Tau as a marker for Alzheimer's disease, Trends Biol. Sci. 18 (1993) 480-483.
70. I.N. Marshall., Consciousness and Bose-Einstein condensates, New ideas in Psychology 7 (1989) 73-83.
71. S. Mascarenhas, The electret effect in bone and biopolymers and the bound water problem, Ann. NY Acad. Sci. 238 (1974) 36-52.
72. S.S. Matsuyama and L.F. Jarvik, Hypothesis: Microtubules, a key to Alzheimer's disease, Proc. Nat. Acad. Sci. 86 (1989) 8152-8156.
73. R. Melki, M.F. Carlier, D. Pantaloni and S.N. Timasheff, Cold depolymerization of microtubules to double rings: Geometric stabilization of assemblies, Biochemistry 28 (1989) 9143-9152.
74. R. Mileusnic, S.P. Rose and P. Tillson, Passive avoidance learning results in region specific changes in concentration of, and incorporation into, colchicine binding proteins in the chick forebrain, Neur. Chem. 34 (1980) 1007-1015.
75. R.J. Montoro, J. Diaz-Nido, J. Avila and J. Lopez-Barneo, N-methyl-d-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus, Neuroscience 54 (4) (1993) 859-871.
76. C. Neubauer, A.M. Phelan, H. Keus and D.G. Lange, Microwave irradiation of rats at 2.45 GHz activates pinocytotic-like uptake of tracer by capillary endothelial cells of cerebral cortex, Bioelectromagnetics 11 (1990) 261-268.
77. P. Pearle, Combining stochastic dynamical state vector reduction with spontaneous localization, Phys. Rev. D. 13 (1989) 857-868.
78. P. Pearle and E. Squires, Bound-state excitation, nucleon decay experiments and models of wave-function collapse, Phys. Rev. Lett. 73 (1) (1994) 1-5.
79. R. Penrose, Newton, quantum theory and reality, in: S.W. Hawking and W. Israel, eds., 300 Years of Gravity (Cambridge University Press, Cambridge, 1987).
80. R. Penrose, The Emperor's New Mind (Oxford University Press, Oxford, 1989).
81. R. Penrose, Shadows of the Mind (Oxford University Press, London, 1994).
82. R. Penrose and L. Onsager, Bose-Einstein condensation and liquid helium, Phys. Rev. 104 (1956) 576-584.
83. T.T. Puck and A. Krystosek, Role of the cytoskeleton in genome regulation and cancer, Int. Rev. Cytology 132 (1992) 75-108.
84. S. Rasmussen, H. Karampurwala, R. Vaidyanath, K.S. Jensen and S. Hameroff, Computational connectionism within neurons: A model of cytoskeletal automata subserving neural networks, Phys. D 42 (1990) 428-449.
85. L.E. Roth and D.J. Pihlaja, Gradionation: Hypothesis for positioning and patterning, J. Protozoology 24 (1) (1977) 2-9.
86. M.V. Sataric, R.B. Zakula and J.A. Tuszynski, A model of the energy transfer mechanisms in microtubules involving a single soliton, Nanobiology (1992) 445-456.
87. P. Satir, Cytoplasmic matrix: Old and new questions. J. Cell Biol. 99 (1) (1984) 235-238.
88. A.C. Scott, Stairway to the Mind (Springer, Berlin, 1995).
89. W. Singer, Synchronization of cortical activity and its putative role in information processing and learning, Ann. Rev. Physiol. 55 (1993) 349-374.
90. H.P. Stapp, Mind, Matter and Quantum Mechanics (Springer, Berlin, 1993).
91. W.E. Theurkauf and R.B. Vallee, Extensive cAMP-dependent and cAMP-independent phosphorylation of microtubule associated protein 2, J. Biol. Chem. 258 (1983) 7883-7886.
92. J. Tuszynski, J., S. Hameroff, M.V. Sataric, B. Trpisova and M.L.A. Nip, Ferroelectric behavior in microtubule dipole lattices; Implications for information processing, signaling and assembly/disassembly, J. Theor. Biol. (1995) in press.
93. P. Vassilev, M. Kanazirska and H.T. Tien, Intermembrane linkage mediated by tubulin, Biochem. Biophys. Res. Comm. 126 (1985) 559-565.
94. C. Von der Marlsburg and W. Schneider, A neural cocktail party processor, Biol. Cybern. 54 (1986) 29-40.
95. J. Von Neumann, Theory of self-reproducing automata, in: A.W. Burks, ed. (University of Illinois Press, Urbana, 1966).
96. N. Wang and D.E. Ingber, Control of cytoskeletal mechanics by extracellular matrix, cell shape and mechanical tension, Biophysical J. 66 (6) (1994) 2181-2189.
97. N.J. Woolf, S.L. Young, G.V.W. Johnson and M.S. Fanselow, Pavlovian conditioning alters cortical microtubule-associated protein-2, NeuroReport 5 (1994) 1045-1048.
98. W. Yu and P.W. Baas, Changes in microtubule number and length during axon differentiation, J. Neuroscience 14 (5) (1994) 2818-2829.