Role of thrombotic risk factors in end-stage renal disease

Clinical and Applied Thrombosis/Hemostasis

Volumn 16, Issue 2, 2010, Pages 132-140

  Tripathi, Gaurav ^a   Sankhwar, Satya Narayan ^a   Sharma, Raj Kumar ^b   Baburaj, Vinod Pandirikkal ^b   Agrawal, Suraksha ^b  

^a CSSMU   (India)

^b SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

End stage renal disease (ESRD); FV leiden; Homocysteine; MTHFR gene polymorphism; Prothrombin; Thrombotic factors

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FOLIC ACID BLOOD LEVEL; GENE FREQUENCY; GENOTYPE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; THROMBOSIS;

3' UNTRANSLATED REGIONS; ADULT; ALLELES; AMINO ACID SUBSTITUTION; FACTOR V; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; KIDNEY FAILURE, CHRONIC; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION, MISSENSE; POINT MUTATION; PROTHROMBIN; RISK FACTORS; THROMBOPHILIA; VITAMIN B 12; YOUNG ADULT;

EID: 77949949876     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029609335911     Document Type: Article

References (29)

1. Ekmekci Y., Keven K., Akar N., et al. Thrombophilia and avascular necrosis of femoral head in kidney allograft recipients. Nephrol Dial Transplant. 2006 ; 21 (12). 3555-3558.
2. Biglarnia A., Bergqvist D., Johansson M., Wadström J. Venous thromboembolism in live kidney donors-a prospective study. Transplantation. 2008 ; 86 (5). 659-661.
3. Girndt M., Heine GH, Ulrich C., Köhler H. ; DialGene Consortium. Gene polymorphism association studies in dialysis: vascular access. Semin Dial. 2007 ; 20 (1). 63-67.
4. Goyette P., Pai A., Milos R., et al. Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome. 1998 ; 9 (8). 652-656.
5. Lorenzo DB, Yang Q. 5, 10-Methylenetetrahydrofolate reductase (MTHFR) Gene Variants and Congenital Anomalies. Am J Epidemiol. 2000 ; 151 (9). 862-877.
6. Ralph C., Jacobsen DW Homocysteine in Health and Disease. Cambridge, UK: Cambridge University Press; 2001: 92-112.
7. Mtiraoui N., Ezzidi I., Chaieb M., et al. MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2007 ; 75 (1). 99-106.
8. Manuela F., Buchmayer H., Heinz G., et al. Effect of MTHFR 1298A/C and MTHFR 677C/T genotypes on total homocysteine, folate, and vitamin B12 plasma concentrations in kidney graft recipients. J Am Soc Nephrol. 2000 ; 11 (10). 1918-1925.
9. Isotalo PA, Donnelly JG Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis. Mol Diagn. 2000 ; 5 (1). 59-66.
10. Okada E., Oida K., Tada H., et al. Hyperhomocysteinemia is a risk factor for coronary arteriosclerosis in Japanese patients with type 2 diabetes. Diabetes Care. 1999 ; 22 (3). 484-490.
11. Arruda VR, von Zuben PM, Chiaparini LC, et al. The mutation C677T in the methylenetetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost. 1997 ; 77 (5). 818-821.
12. Kim OJ, Hong SP, Ahn JY, et al. Influence of combined methionine synthase (MTR 2756A>G) and methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke. Yonsei Med J. 2007 ; 48 (2). 201-209.
13. Hultberg B., Andersson A., Sterner G. Plasma homocysteine in renal failure. Clin Nephrol. 1993 ; 40 (4). 230-235.
14. Frosst P., Bloom HJ, Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995 ; 10 (1). 111-113.
15. Lewis SJ, Ebrahim S., Davey Smith G. Meta-analysis of MTHFR 677 C-T polymorphism and coronary hart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 7. 2005 ; 331 (7524). 1053.
16. Ulvik A., Ueland PM, Fredriksen A., et al. Functional inference of the methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphism from a large-scale epidemiological study. Hum Genet. 2007 ; 121 (1). 57-64.
17. Zoccali C., Enia G., Tripepi G., et al. Clinical epidemiology of major nontraditional risk factors in peritoneal dialysis patients. Perit Dial Int. 2005 ; 25 (suppl 3). 84-87.
18. Skoupy S., Födinger M., Veitl M., et al. Riboflavin is a determinant of total homocysteine plasma concentrations in end-stage renal disease patients. J Am Soc Nephrol. 2002 ; 13 (5). 1331-1337.
19. Van der Put NMJ, Gabreels F., Stevens EM, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects ? Am J Hum Genet. 1998 ; 62 (5). 1044-1051.
20. Weisberg I., Tran P., Christensen B., et al. A second genetic polymorphism in methylene tetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol. Genet. Metab. 1998 ; 64 (3). 169-172.
21. Abramson N., Joseph P., Costantino Judy E., Garber, Berliner N., Lawrence D. Effect of factor V leiden and prothrombin G20210A mutation on thromboembolic risk in national surgical adjuent breast and bowel project breast cancer. J Natl Cancer Inst. 2006 ; 98 (13). 904-910.
22. DarrinCox E., Steven C Hoffmann, Barbara S DiMercurio, et al. Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukins-2 and intrleukins-6. Transplantation. 2001 ; 72 (8). 720-726.
23. Domenici FA, Vannucchi MT, Simes-Ambr3sio LM, et al. Hyperhomocysteinemia and polymorphisms of the methylenetetrahydrofolate gene in hemodialysis and peritoneal dialysis patients. Mol Nutr Food Res. 2007 ; 51 (11). 1430-1436.
24. Bertina RM, Koeleman BP, Koster T., et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994 ; 369 (6475). 64-67.
25. Kranz B., Vester U., Nadalin S., Paul A., Broelsch CE, Hoyer PF Outcome after kidney transplantation in children with thrombotic risk factors. Pediatr Transplant. 2006 ; 10 (7). 788-793.
26. Breslow NE, Day NE Statistical method in cancer research: the analysis of case control studies. Int Agency Res. Cancer. 1980 ; 1: 162-186.
27. Cossu M., Carru C., Pes GM, et al. Plasma homocysteine levels and C677T MTHFR gene polymorphism in stable renal graft recipients. Transplant Proc. 2001 ; 33 (1-2). 1156-1158.
28. Poduri A., Mukherjee D., Sud K., Kohli HS, Sakhuja V., Khullar M. MTHFR A1298C polymorphism is associated with cardiovascular risk in end stage renal disease in North Indians. Mol Cell Biochem. 2008 ; 308 (1-2). 43-50.
29. Guenther BD, Sheppard CA, Tran P., Rozen R., Matthews RG, Ludwig ML The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol. 1999 ; 6 (4). 359-365.