Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C

Cellular Physiology and Biochemistry

Volumn 25, Issue 4-5, 2010, Pages 389-396

  Kongsuphol, Patthara ^a   Cassidy, Diane ^b   Romeiras, Francisco ^a   Schreiber, Rainer ^a   Mehta, Anil ^b   Kunzelmann, Karl ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

CFTR AMP; Chloride secretion; Cystic fibrosis transmembrane conductance regulator; Metformin; Pancreas; Pancreatitis; PKA AMP activated protein kinase; S573C

Indexed keywords

CHLORIDE; CYCLIC AMP; CYSTEINE; METFORMIN; SERINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ACIDIFICATION; ACIDOSIS; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; NONHUMAN; OOCYTE; PANCREATITIS; POINT MUTATION; PRIORITY JOURNAL; RISK FACTOR; XENOPUS;

EID: 77949931738     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000303043     Document Type: Article

References (32)

1. Sohma Y, Gray MA, Imai Y, Argent BE: 150 mM HCO3(-)-how does the pancreas do it? Clues from computer modelling of the duct cell. JOP 2001;2:198-202.
2. Choi JY, Muallem D, Kiselyov K, Lee MG, Thomas PJ, Muallem S: Aberrant CFTR-dependent HCO3-transport in mutations associated with cystic fibrosis. Nature 2001;410:94-97.
3. Gray MA, O'Reilly C, Winpenny J, Argent B: Functional interactions of HCO3-with cystic fibrosis transmembrane conductance regulator. JOP 2001;2:207-211.
4. Novak I: Keeping up with bicarbonate. J Physiol 2000;528:235.
5. Wang Y, Soyombo AA, Shcheynikov N, Zeng W, Dorwart M, Marino CR, Thomas PJ, Muallem S: Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO(3)(-) secretion: relevance to cystic fibrosis. EMBO J 2006;25:5049-5057.
6. Yang D, Shcheynikov N, Zeng W, Ohana E, So I, Ando H, Mizutani A, Mikoshiba K, Muallem S: IRBIT coordinates epithelial fluid and HCO3-secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest 2008;36983.
7. Rosenstein BJ, Cutting GR: The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel [see comments]. J Pediatr 1998;132:589-595.
8. Cohn JA, Friedman KJ, Noone PG, Knowles MR, Silverman LM, Jowell PS: Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis [see comments]. N Engl J Med 1998;339:653-658.
9. Ren CL: Mutations of the cystic fibrosis gene and pancreatitis. N Engl J Med 1999;340:238-239.
10. Chen JM, Ferec C: Molecular basis of hereditary pancreatitis. Eur J Hum Genet 2000;8:473-479.
11. Sharer N, Schwarz M, Malone G, Howarth A, Painter J, Super M, Braganza J: Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998;339:645-652.
12. Cohn JA, Mitchell RM, Jowell PS: The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis. Gastroenterol Clin North Am 2004;33:817-37, vii.
13. Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK: Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest 2000;105:1711-1721.
14. Kongsuphol P, Cassidy D, Hieke B, Treharne KJ, Schreiber R, Mehta A, Kunzelmann K: Mechanistic insight into control of CFTR by AMPK. J Biol Chem 2009;284:5645-5653.
15. Hardie DG, Hawley SA, Scott JW: AMP-activated protein kinase-development of the energy sensor concept. J Physiol 2006;574:7-15.
16. Hawley SA, Gadalla AE, Olsen GS, Hardie DG: The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002;51:2420-2425.
17. Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL: Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells. Br J Pharmacol 2007;151:1204-1215.
18. Mallick S: Metformin induced acute pancreatitis precipitated by renal failure. Postgrad Med J 2004;80:239-240.
19. Fimognari FL, Corsonello A, Pastorell R, Antonelli-Incalzi R: Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure. Diabetes Care 2006;29:1183.
20. Schrijver I, Ramalingam S, Sankaran R, Swanson S, Dunlop CL, Keiles S, Moss RB, Oehlert J, Gardner P, Wassman ER, Kammesheidt A: Diagnostic testing by CFTR gene mutation analysis in a large group of Hispanics: novel mutations and assessment of a population-specific mutation spectrum. J Mol Diagn 2005;7:289-299.
21. Keiles S, Kammesheidt A: Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. Pancreas 2006;33:221-227.
22. Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK: Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem 2003;278:998-1004.
23. Kongsuphol P, Hieke B, Ousingsawat J, Almaca J, Viollet B, Schreiber R, Kunzelmann K: Regulation of Cl-secretion by AMPK in vivo. Pflügers Arch 2008;457:1071-1078.
24. Chen JH, Cai Z, Sheppard DN: Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl-channel. J Biol Chem 2009;284:35495-35506.
25. Chase HS, Jr., Mogan GR: Phenformin-associated pancreatitis. Ann Intern Med 1977;87:314-315.
26. Paterson KR, Paice BJ, Lawson DH: Undesired effects of biguanide therapy. Adverse Drug React Acute Poisoning Rev 1984;3:173-182.
27. Hegyi P, Rakonczay Z, Jr., Farkas K, Venglovecz V, Ozsvari B, Seidler U, Gray MA, Argent BE: Controversies in the role of SLC26 anion exchangers in pancreatic ductal bicarbonate secretion. Pancreas 2008;37:232-234.
28. - secretion. J Physiol (Lond) 1997;505:411-423.
29. Singh AK, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann U, De Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U: Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest 2009;119:540-550.
30. O'Reilly CM, Winpenny JP, Argent BE, Gray MA: Cystic fibrosis transmembrane conductance regulator currents in guinea pig pancreatic duct cells: inhibition by bicarbonate ions. Gastroenterology 2000;118:1187-1196.
31. Bates CM, Baum M, Quigley R: Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent. J Am Soc Nephrol 1997;8:352-355.
32. Reddy MM, Kopito RR, Quinton PM: Cytosolic pH regulates GCl through control of phosphorylation states of CFTR. Am J Physiol 1998;275:C1040-C1047.