GABRA2 and alcohol use disorders: No evidence of an association in an Italian case-control study

Alcoholism: Clinical and Experimental Research

Volumn 34, Issue 4, 2010, Pages 659-668

  Onori, Nicoletta ^a   Turchi, Chiara ^a   Solito, Giovanni ^a   Gesuita, Rosaria ^a   Buscemi, Loredana ^a   Tagliabracci, Adriano ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

3' GABRA2 Gene; Alcohol Use Disorders; Association Studies; Comorbidity; SNPs

Indexed keywords

ACCIDENT; ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; BEHAVIOR CHANGE; COMORBIDITY; CONTROLLED STUDY; DRINKING BEHAVIOR; ENVIRONMENTAL FACTOR; FEMALE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOTYPE; HEREDITY; HUMAN; ITALY; LEGAL ASPECT; MALE; MORBIDITY; MORTALITY; MOTOR COORDINATION; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; SEDATION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL PROBLEM; VIOLENCE;

ADULT; ALCOHOL-INDUCED DISORDERS; ALCOHOLISM; ALLELES; CASE-CONTROL STUDIES; DIPLOIDY; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HAPLOTYPES; HUMANS; ITALY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A;

EID: 77949926526     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2009.01135.x     Document Type: Article

References (35)

1. Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Nurnberger JI, Crowe R, Kuperman S, Schuckit MA, Begleiter H, Porjesz B, Dick DM (2006) Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36 : 640 650.
2. Ball D (2007) Addiction science and its genetics. Addiction 103 : 360 367.
3. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) International Union of Pharmacology. XV. Subtypes of γ-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol Rev 50 : 291 313.
4. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 : 263 265.
5. Brisighelli F, Capelli C, Boschi I, Garagnani P, Lareu MV, Pascali VL, Carracedo A (2009) Allele frequencies of fifteen STRs in a representative sample of the Italian population. Forensic Sci Int Genetics 3 : e29 e30.
6. Buckland PR (2001) Genetic association studies of alcoholism - problems with the candidate gene approach. Alcohol Alcohol 36 : 99 103.
7. Buckland PR (2008) Will we ever find the genes for addiction? Addiction 103 : 1768 1776.
8. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR (2004) Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 129B : 104 109.
9. Covault J, Gelernter J, Jensen K, Anton R, Kranzler HR (2008) Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology 33 : 837 848.
10. Drgon T, D'Addario C, Uhl GR (2006) Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr Genet 141B : 854 860.
11. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI Jr., O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74 : 705 714.
12. Enoch MA, Hodgkinson CA, Yuan Q, Albaugh B, Virkkunen M, Goldman D (2009) GABRG1 and GABRA2 as Independent Predictors for Alcoholism in Two Populations. Neuropsychopharmacology 34 : 1245 1254.
13. Fehr C, Sander T, Tadic A, Lenzen KP, Anghelescu I, Klawe C, Dahmen N, Schmidt LG, Szegedi A (2006) Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet 16 : 9 17.
14. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, Higgins J, DeFelice M, Lochner A, Faggart M, Liu-Cordero SN, Rotimi C, Adeyemo A, Cooper R, Ward R, Lander ES, Daly MJ, Altshuler D (2002) The structure of haplotype blocks in the human genome. Science 296 : 2225 2229.
15. Grobin AC, Matthews DB, Devaud LL, Morrow AL (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139 : 2 19.
16. Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (2008) Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4. Genomics 91 : 61 69.
17. Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J (2005) Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol Clin Exp Res 29 : 493 498.
18. Liu K, Muse SV (2005) PowerMarker: integrated analysis environment for genetic marker data. Bioinformatics 21 : 2128 2129.
19. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81 : 216 221.
20. Luo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J (2006) ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies. Neuropsychopharmacology 31 : 1085 1095.
21. Lynskey MT, Nelson EC, Neuman RJ, Bucholz KK, Madden PA, Knopik VS, Slutske W, Whitfield JB, Martin NG, Heath AC (2005) Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins. Twin Res Hum Genet 8 : 574 584.
22. Matthews AG, Hoffman EK, Zezza N, Stiffler S, Hill SY (2007) The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. J Stud Alcohol Drugs 68 : 625 633.
23. McGue M (1999) The behavioral genetics of alcoholism. Curr Dir Psychol Sci 8 : 109 115.
24. National Health and Medical Research Council. (1992) Is There a Safe Level of Daily Consumption of Alcohol for Men and Women? 2nd ed. Australian Government Publishing Service, Canberra.
25. Porjesz B, Almasy L, Edenberg HJ, Wang K, Chorlian DB, Foroud T, Goate A, Rice JP, O'Connor SJ, Rohrbaugh J, Kuperman S, Bauer LO, Crowe RR, Schuckit MA, Hesselbrock V, Conneally PM, Tischfield JA, Li TK, Reich T, Begleiter H (2002) Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci U S A 99 : 3729 3733.
26. Ray LA, Hutchison KE (2009) Associations among GABRG1, level of response to alcohol, and drinking behaviors. Alcohol Clin Exp Res 33 : 1382 1390.
27. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, Foroud T, Hesselbrock V, Schuckit MA, Bucholz K, Porjesz B, Li TK, Conneally PM, Nurnberger JI Jr., Tischfield JA, Crowe RR, Cloninger CR, Wu W, Shears S, Carr K, Crose C, Willig C, Begleiter H (1998) Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet 81 : 207 215.
28. Rozen S, Skaletsky J (2000) Primer 3 on the WWW for general users and for biologist programmers, in Bioinformatics Methods and Protocols: Methods in Molecular Biology (Krawetz S, Misener S eds pp 365 386. Humana Press, Totowa, NJ.
29. Schuckit MA (2009) An overview of genetic influences in alcoholism. J Subst Abuse Treat 36 : S5 S14.
30. Soyka M, Preuss UW, Hesselbrock V, Zill P, Koller G, Bondy B (2008) GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res 42 : 184 191.
31. Stephens M, Donnelly P (2003) A comparison of Bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73 : 1162 1169.
32. Stephens M, Smith NJ, Donnelly P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68 : 978 989.
33. Tian H, Chen HJ, Cross TH, Edenberg HJ (2005) Alternative splicing and promoter use in the human GABRA2 gene. Brain Res Mol Brain Res 137 : 174 183.
34. Vallone PM, Butler JM (2004) AutoDimer: a screening tool for primer dimer and hairpin structures. Biotechniques 37 : 226 231.
35. Zinn-Justin A, Abel L (1999) Genome search for alcohol dependence using the weighted pairwise correlation linkage method: interesting findings on chromosome 4. Genet Epidemiol 17 (Suppl 1 S421 S426.