Asymmetric dimethylarginine (ADMA) is present in plasma proteins of healthy subjects at the low nmol-per-g-level

Nitric Oxide - Biology and Chemistry

Volumn 22, Issue 4, 2010, Pages 316-317

  Tsikas, Dimitrios ^a   Engeli, Stefan ^a   Beckmann, Bibiana ^a   Jordan, Jens ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ADMA; GC MS MS; Hydrolysis; Nutrition; Plasma proteins

Indexed keywords

AMINO ACID; ARGININE; DIMETHYLARGININASE; GUANIDINE; GUANIDINE NITROGEN; HUMAN SERUM ALBUMIN; N(G),N(G) DIMETHYLARGININE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; NITROGEN; PLASMA PROTEIN; PROTEIN ARGININE METHYLTRANSFERASE; UNCLASSIFIED DRUG;

CARDIOVASCULAR RISK; ERYTHROCYTE; FIRST PASS EFFECT; HUMAN; HYDROLYSIS; LETTER; LIPID DIET; MASS FRAGMENTOGRAPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN METHYLATION; PROTEIN STRUCTURE; ROOM TEMPERATURE; VASODILATATION;

ARGININE; BLOOD PROTEINS; ENZYME INHIBITORS; FEMALE; HUMANS; MALE;

EID: 77949917115     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2009.12.005     Document Type: Letter

References (10)

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2. Tsikas D., Schubert B., Gutzki F.M., Sandmann J., and Schwedhelm E. Quantitative determination of circulating and urinary asymmetric dimethylarginine (ADMA) in humans by gas chromatography-tandem mass spectrometry as methyl ester tri(N-pentafluoropropionyl) derivative. J. Chromatogr. B 798 (2003) 87-99
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4. Tsikas D., and Beckmann B. Albumin from human serum does not contain asymmetric dimethylarginine (ADMA). Clin. Biochem. 42 (2009) 1739-1740
5. (author reply 1741)
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10. Kielstein J.T., Tsikas D., and Fliser D. Effects of asymmetric dimethylarginine (ADMA) infusion in humans. Eur. J. Clin. Pharmacol. 62 (2006) 39-44