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Volumn 21, Issue 5, 2010, Pages 507-510

Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives

Author keywords

Antimicrobial activity; C 2(S) substituted; Pleuromutilin; Synthesis

Indexed keywords


EID: 77949917074     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2010.01.001     Document Type: Article
Times cited : (11)

References (13)
  • 12
    • 77949917901 scopus 로고    scopus 로고
    • The data of 6a, 6b; 7a, 7b; 6a: White solid, yield 88.3, mp: 127-129 °C;, α ]D20 -4.7 (c 0.75, MeOH, 1H NMR (300 MHz, CDCl3, δ 0.88 (d, 3H, J, 7.0 Hz, 0.94 (d, 3H, J, 6.4 Hz, 1.07-1.38 (m, 4H, 1.08 (s, 3H, 1.39 (s, 3H, 1.80-1.95 (m, 4H, 2.05-2.10 (m, 2H, 2.36 (s, 1H, 3.36 (d, 1H, 4.79 (t, 1H, J, 8.1 Hz, 5.25 (d, 1H, J, 17.9 Hz, 5.36 (d, 1H, J, 11.2 Hz, 5.76 (d, 1H, J, 8.1 Hz, 6.41 (dd, 1H, J, 18.0 Hz, 11.2 Hz, 7.23 (d, 2H, J, 8.6 Hz, 7.80 (d, 2H, J, 8.5 Hz, 9.40 (s, 1H, MS (ESI) m/z: 500.2, M-H], Anal. Calcd. for C28H36FNO6:C, 67.23; H, 7.14; N, 2.95. Found: C, 67.05; H, 7.23; N, 2.79; 6b: White solid, yield 95.1, mp: 141-143 °C;, α ]D20 +5.6 (c 1.0, MeOH, 1H NMR (300 MHz, CDCl3, δ 0.87 (d, 3H, J, 6.8 Hz, 0.91 (d, 3H, J, 6.7 Hz, 0.96 (t, 3H, 1.09-1.35 (m, 6H, 1.13 (s, 3H, 1.41 s
    • 7:C, 66.87; H, 7.67; N, 2.92. Found: C, 67.04; H, 7.84; N, 2.79.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.