Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 18, 2009, Pages 5407-5410

  Fu, Liqiang ^a   Jiang, Zhiteng ^a   cai, Zhan ^a   Liu, Xin ^a   He, Huili ^a   Yang, Yushe ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Gram positive bacteria; Pleuromutilin; Water soluble phosphate prodrugs

Indexed keywords

LINEZOLID; PHOSPHATE; PLEUROMUTILIN; PRODRUG; RETAPAMULIN; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; MALE; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RAT; STAPHYLOCOCCUS INFECTION;

ANIMALS; ANTI-BACTERIAL AGENTS; DITERPENES; GRAM-POSITIVE BACTERIA; MICE; MICROBIAL SENSITIVITY TESTS; PHOSPHATES; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STAPHYLOCOCCAL INFECTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA;

EID: 68949116095     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.115     Document Type: Article

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