Pleuromutilin antibiotics

Drugs of the Future

Volumn 25, Issue 11, 2000, Pages 1163-1168

  Hunt, E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PLEUROMUTILIN; SB 222734; SB 225586; SB 247386; SB 258781; SB 264128; SB 268091; SB 304946; SB 328636; SB 452466; TIAMULIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; BINDING AFFINITY; DRUG BINDING; DRUG CLEARANCE; DRUG MECHANISM; DRUG METABOLISM; HUMAN; HUMAN CELL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0034501311     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2000.025.11.858699     Document Type: Review

References (48)

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2. Chemical studies with pleuromutilin
3. The structure of a new class of terpene
4. The diterpenoid nature of pleuromutilin
5. The structure and some aspects of the biosynthesis of pleuromutilin
6. Pleuromutilins. Fermentation, structure and biosynthesis
7. Studies on pleuromutilin and some of its derivatives
8. New pleuromutilin derivatives with enhanced antimicrobial activity: I. Synthesis
9. New pleuromutilin derivatives with enhanced antimicrobial activity: II. Structure-activity correlations
10. Tiamulin and pleuromutilin
11. TDM 85-530: Toxicity in laboratory animals, tolerance and pharmacokinetics after oral application to volunteers
12. In vitro susceptibilities of recent field isolates of Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae to valnemulin (Econor), tiamulin and enrofloxacin and the in vitro development of resistance to certain antimicrobial agents in Mycoplasma hyopneumoniae
13. A-40104, a new group of pleuromutilin related antibiotics. I. Isolation, characterisation and structures of A-40104A and A-40104B
14. Antimicrobial resistance: Prognosis for public health
15. Current approaches to overcome bacterial resistance
16. The mode of action of pleuromutilin derivatives
17. Ribosomal binding region for the antibiotic tiamulin: Stoichiometry, subunit location, and affinity for various analogs
18. Tiamulin resistant mutations in Escherichia coli
19. The mode of action of pleuromutilin derivatives. Effect on cell-free polypeptide synthesis
20. The effects of tiamulin, a semi-synthetic pleuromutilin derivative, on bacterial polypeptide chain initiation
21. The ribosome as a target for novel antibacterials
22. Homogeneous fluorescence assays for miniturised uHTS: Drug-RNA interactions
23. Antimicrobial activity of 81.723 hfu, a new pleuromutilin derivative
24. The activity of TDM 85.530 against Chlamydia trachomatis and Ureaplasma urealyticum in vitro
25. In vitro activity of TDM 85.530 against selected aerobic bacteria
26. Comparative activity of TDM 85.530, clindamycin and metronidazole against anaerobes
27. TDM 85.530: A pleuromutilin derivative and its spectrum of antibacterial activity in vitro
28. In vitro activity of two novel pleuromutilin derivatives, SB-247386 and SB-268091
29. In vivo evaluation of TDM 85.530
30. In vivo efficacy of the novel topical pleuromutilins, SB-247386 and SB-268091
31. In vitro activity of the novel pleuromutilin SB-264128 against organisms associated with respiratory tract infections
32. In vivo efficacy of the novel oral pleuromutilin, SB-264128
33. Deuteration of TDM 85-530 at the sites of CYP-P450 dependent oxidation and its influence on the rate of degradation
34. Uptake, distribution and metabolism of TDM 3H 85-530 in the rat. A comparison of in vitro and in vivo data
35. Binding and degradation of TDM 85-530 by a microsomal CYP P450 form from man, rat and mouse in vitro
36. TDM 85-530: Pharmacokinetics and biotransformation of the 3H-labelled drug in laboratory animals and man
37. Chemistry of pleuromutilins, 3. Synthesis of 14-O-acetyl-19,20-dihydro-A-nor-mutilins
38. Chemistry of pleuromutilins, IV. Synthesis of 14-O-acetyl-8-alpha-hydroxymutilins
39. Chemistry of pleuromutilins, IX. Reverse configuration of the methyl group with C-6 tricyclic structure of pleuromutilin diterpenes