Regulatory effect of acetyl-l-carnitine on expression of lenticular antioxidant and apoptotic genes in selenite-induced cataract

Chemico-Biological Interactions

Volumn 184, Issue 3, 2010, Pages 346-351

  Elanchezhian, R ^a   Sakthivel, M ^a   Geraldine, P ^a   Thomas, P A ^b  

^a BHARATHIDASAN UNIVERSITY   (India)

^b JOSEPH EYE HOSPITAL   (India)

Author keywords

Acetyl l carnitine; Caspase 3; COX I; EGR 1; Gene expression; Selenite cataract

Indexed keywords

CASPASE 3; CATALASE; CYTOCHROME C OXIDASE; EARLY GROWTH RESPONSE FACTOR 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LEVACECARNINE; MESSENGER RNA; SELENITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; IONIZING RADIATION; MEMBRANE DEPOLARIZATION; MITOCHONDRION; NONHUMAN; RAT; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ACETYLCARNITINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CATALASE; CATARACT; CYCLOOXYGENASE 1; EARLY GROWTH RESPONSE PROTEIN 1; ELECTRON TRANSPORT COMPLEX IV; LENS, CRYSTALLINE; RATS; RATS, WISTAR; SODIUM SELENITE; VITAMIN B COMPLEX;

RATTUS; RATTUS NORVEGICUS;

EID: 77949913048     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.01.006     Document Type: Article

References (44)

1. Wormstone I.M., Collison D.J., Hansom S.P., Duncan G. A focus on the human lens in vitro. Environ. Toxicol. Pharmacol. 2006, 21:215-221.
2. Li W.C., Kuszak J.R., Wang G.M., Wu Z.Q., Spector A. Calcimycin-induced lens epithelial cell apoptosis contributes to cataract formation. Exp. Eye Res. 1995, 61:91-98.
3. Spector A., Wang G.M., Wang R.R., Li W.C., Kuszak J.R. A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. I. Transparency and epithelial cell layer. Exp. Eye Res. 1995, 60:471-481.
4. Michael R., Vrensen G.F., van Marle J., Gan L., Söderberg P.G. Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation. Invest. Ophthalmol. Vis. Sci. 1998, 39:2681-2687.
5. Takamura Y., Kubo E., Tsuzuki S., Akagi Y. Apoptotic cell death in the lens epithelium of rat sugar cataract. Exp. Eye Res. 2003, 77:51-57.
6. Anderson R.S., Shearer T.R., Claycomb C.K. Selenite-induced epithelial damage and cortical cataract. Curr. Eye Res. 1986, 5:53-61.
7. Cenedella R.J. Direct chemical measurement of DNA synthesis and net rates of differentiation of rat lens epithelial cells in vivo: applied to the selenium cataract. Exp. Eye Res. 1987, 44:677-690.
8. Huang L.L., Hess J.L., Bunce G.E. DNA damage, repair, and replication in selenite-induced cataract in rat lens. Curr. Eye Res. 1990, 9:1041-1050.
9. 2+ transport. Curr. Eye Res. 1993, 12:213-218.
10. Nakajima T., Nakajima E., Fukiage C., Azuma M., Shearer T.R. Differential gene expression in the lens epithelial cells from selenite injected rats. Exp. Eye Res. 2002, 74:231-236.
11. Bantseev V., Youn H.Y. Mitochondrial " movement" and lens optics following oxidative stress from UV-B irradiation: cultured bovine lenses and human retinal pigment epithelial cells (ARPE-19) as examples. Ann. N.Y. Acad. Sci. 2006, 1091:17-33.
12. Boise L.H., González-García M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nuñez G., Thompson C.B. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993, 74:597-608.
13. Yao K., Ye P., Zhang L., Tan J., Tang X., Zhang Y. Epigallocatechin gallate protects against oxidative stress-induced mitochondria-dependent apoptosis in human lens epithelial cells. Mol. Vis. 2008, 14:217-223.
14. Chang B., Nishikawa M., Sato E., Utsumi K., Inoue M. l-Carnitine inhibits cisplatin-induced injury of the kidney and small intestine. Arch. Biochem. Biophys. 2002, 405:55-64.
15. Pillich R.T., Scarsella G., Risuleo G. Reduction of apoptosis through the mitochondrial pathway by the administration of acetyl-l-carnitine to mouse fibroblasts in culture. Exp. Cell Res. 2005, 306(1):1-8.
16. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning. A Laboratory 1989, Cold Spring Harbor Laboratory Press, New York.
17. Burke P.V., Poyton R.O. Structure/function of oxygen-regulated isoforms in cytochrome c oxidase. J. Exp. Biol. 1998, 201:1163-1175.
18. Chen S.J., Bradley M.E., Lee T.C. Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases. Mol. Cell. Biochem. 1998, 178:141-149.
19. Gashler A., Sukhatme V.P. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 1995, 50:191-224.
20. Wyllie A.H. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev. 1992, 11:95-103.
21. Zhu X., Sato E.F., Wang Y., Nakamura H., Yodoi J., Inoue M. Acetyl-l-carnitine suppresses apoptosis of thioredoxin 2-deficient DT40 cells. Arch. Biochem. Biophys. 2008, 478:154-160.
22. Bhuyan K.C., Bhuyan D.K., Katzin H.M. Amizol-induced cataract and inhibition of lens catalase in rabbit. Ophthal. Res. 1973, 5:236-247.
23. 2-resistant lens epithelial cell line. Free Radic. Biol. Med. 2001, 31:90-97.
24. Geraldine P., Sneha B.B., Elanchezhian R., Ramesh E., Kalavathy C.M., Kaliamurthy J., Thomas P.A. Prevention of selenite-induced cataractogenesis by acetyl-l-carnitine: an experimental study. Exp. Eye Res. 2006, 83:1340-1349.
25. Elanchezhian R., Ramesh E., Sakthivel M., Isai M., Geraldine P., Rajamohan M., Jesudasan C.N., Thomas P.A. Acetyl-l-carnitine prevents selenite-induced cataractogenesis in an experimental animal model. Curr. Eye Res. 2007, 32:961-971.
26. Yan Q., Liu J.P., Li D.W. Apoptosis in lens development and pathology. Differentiation 2006, 74:195-211.
27. Yao K., Tan J., Gu W.Z., Ye P.P., Wang K.J. Reactive oxygen species mediates the apoptosis induced by transforming growth factor beta(2) in human lens epithelial cells. Biochem. Biophys. Res. Commun. 2007, 354:278-283.
28. Elanchezhian R., Sakthivel M., Geraldine P., Thomas P.A. The effect of acetyl-l-carnitine on lenticular calpain activity in prevention of selenite-induced cataractogenesis. Exp. Eye Res. 2009, 88:938-944.
29. Arai M., Yoguchi A., Takizawa T., Yokoyama T., Kanda T., Kurabayashi M., Nagai R. Mechanism of doxorubicin-induced inhibition of sarcoplasmic reticulum Ca(2+)-ATPase gene transcription. Circ. Res. 2000, 86:8-14.
30. Liu C., Rangnekar V.M., Adamson E., Mercola D. Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther. 1998, 5:3-28.
31. Nakajima T., Belusko P.B., Walkup R.D., Azuma M., Shearer T.R. Involvement of Egr-1 in lens epithelial cell death induced by selenite. Exp. Eye Res. 2006, 82:874-878.
32. Turpeenoja L., Villa R.F., Magri M.G., Giuffrida-Stella A.M. Changes of mitochondrial membrane proteins in rat cerebellum during aging. Neurochem. Res. 1988, 13:859-865.
33. Villa R.F., Turpeenoja L., Benzi G., Giuffrida-Stella A.M. Action of l-acetylcarnitine on age-dependent modifications of mitochondrial membrane protein from rat cerebellum. Neurochem. Res. 1988, 13:909-916.
34. Ragusa N., Turpeenoja L., Magri G., Lahdesmaki P., Giuffrida-Stella A.M. Age-dependent modifications of mitochondrial proteins in cerebral cortex and striatum of rat brain. Neurochem. Res. 1989, 14:415-418.
35. Gadaleta M.N. Aging and mitochondrial DNA transcription process. It. Biochem. Soc. Trans. 1990, 1:64.
36. Fernandez-Silva P., Petruzzella V., Fracasso F., Gadaleta M.N., Cantatore P. Age related changes of RNA synthesis in isolated mitochondria from rat brain. It. Biochem. Soc. Trans. 1990, 1:274.
37. Miura M., Zhu H., Rotello R., Hartwieg E.A., Yuan J. Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993, 75:653-660.
38. Nicholson D.W., Ali A., Thornberry N.A., Vaillancourt J.P., Ding C.K., Gallant M., Gareau Y., Griffin P.R., Labelle M., Lazebnik Y.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 376:37-43.
39. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-347.
40. Kaufmann S.H., Desnoyers S., Ottaviano Y., Davidson N.E., Poirier G.G. Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 1993, 53:3976-3985.
41. Tamada Y., Fukiage C., Nakamura Y., Azuma M., Kim Y.H., Shearer T.R. Evidence for apoptosis in the selenite rat model of cataract. Biochem. Biophys. Res. Commun. 2000, 275:300-306.
42. Binienda Z.K. Neuroprotective effects of l-carnitine in induced mitochondrial dysfunction. Ann. N.Y. Acad. Sci. 2003, 993:289-295. discussion 345-9.
43. Pettegrew J.W., Levine J., McClure R.J. Acetyl-l-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Mol. Psychiatry 2000, 5:616-632.
44. Chang B., Nishikawa M., Nishiguchi S., Inoue M. l-Carnitine inhibits hepatocarcinogenesis via protection of mitochondria. Int. J. Cancer 2005, 113:719-729.