Mexiletine suppresses nodal persistent sodium currents in sensory axons of patients with neuropathic pain

Clinical Neurophysiology

Volumn 121, Issue 5, 2010, Pages 719-724

  Isose, Sagiri ^a   Misawa, Sonoko ^a   Sakurai, Kenichi ^a   Kanai, Kazuaki ^a   Shibuya, Kazumoto ^a   Sekiguchi, Yukari ^a   Nasu, Saiko ^a   Noto, Yuichi ^a,b   Fujimaki, Yumi ^a,c   Yokote, Koutaro ^a   Kuwabara, Satoshi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL   (Japan)

Author keywords

Mexiletine; Pain; Paresthesia; Polyneuropathy; Sodium channel

Indexed keywords

MEXILETINE; SODIUM ION;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; FEMALE; HUMAN; HYPERPOLARIZATION; LATENT PERIOD; MALE; MOTOR NERVE; NERVE EXCITABILITY; NERVE FIBER; NEUROPATHIC PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PARESTHESIA; PRIORITY JOURNAL; SENSORY NERVE; SODIUM CURRENT;

ADULT; AGED; AXONS; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGICAL PHENOMENA; FEMALE; HUMANS; LIDOCAINE; MALE; MEXILETINE; MIDDLE AGED; NEURALGIA; PAIN THRESHOLD; PARESTHESIA; RADIAL NERVE; SENSORY RECEPTOR CELLS; SODIUM CHANNELS;

EID: 77949912179     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinph.2009.12.034     Document Type: Article

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