Neural Cell adhesion molecule in cancer: Expression and mechanisms

Advances in Experimental Medicine and Biology

Volumn 663, Issue , 2010, Pages 319-333

  Zecchini, Silvia ^b   Cavallaro, Ugo ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR; NERVE CELL ADHESION MOLECULE; ISOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BRAIN CANCER; CARCINOGENESIS; DIGESTIVE SYSTEM CANCER; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; LUNG SMALL CELL CANCER; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR INTERACTION; MULTIPLE MYELOMA; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; THYROID CANCER; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; ANIMAL; GENETICS; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; HUMANS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; NEURAL CELL ADHESION MOLECULES; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION;

EID: 77949907296     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1170-4_20     Document Type: Article

References (70)

1. Cavallaro U, Christofori G (2004) Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 4:118-132 (Pubitemid 38198740)
2. Bruses JL, Rutishauser U (2001) Roles, regulation, and mechanism of polysialic acid function during neural development. Biochimie 83:635-643 (Pubitemid 32821227)
3. Jimbo T, Nakayama J, Akahane K, Fukuda M (2001) Effect of polysialic acid on the tumor xenografts implanted into nude mice. Int J Cancer 94:192-199 (Pubitemid 32911412)
4. Gluer S, Zense M, Radtke E, von Schweinitz D (1998) Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage. Langenbecks Arch Surg 383:340-344 (Pubitemid 28527031)
5. Seidenfaden R, Krauter A, Schertzinger F, Gerardy-Schahn R, Hildebrandt H (2003) Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions. Mol Cell Biol 23:5908-5918 (Pubitemid 36951351)
6. Sasaki H, Yoshida K, Ikeda E et al (1998) Expression of the neural cell adhesion molecule in astrocytic tumors: an inverse correlation with malignancy. Cancer 82:1921-1931 (Pubitemid 28208649)
7. Krushel LA, Tai MH, Cunningham BA, Edelman GM, Crossin KL (1998) Neural cell adhesion molecule (N-CAM) domains and intracellular signaling pathways involved in the inhibition of astrocyte proliferation. Proc Natl Acad Sci USA 95:2592-2596 (Pubitemid 28145987)
8. Komminoth P, Roth J, Saremaslani P, Matias-Guiu X, Wolfe HJ, Heitz PU (1994) Polysialic acid of the neural cell adhesion molecule in the human thyroid: a marker for medullary thyroid carcinoma and primary C-cell hyperplasia. An immunohistochemical study on 79 thyroid lesions. Am J Surg Pathol 18:399-411 (Pubitemid 24093604)
9. Lantuejoul S, Moro D, Michalides RJ, Brambilla C, Brambilla E (1998) Neural cell adhesion molecules (NCAM) and NCAM-PSA expression in neuroendocrine lung tumors. Am J Surg Pathol 22:1267-1276 (Pubitemid 28462775)
10. Trouillas J, Daniel L, Guigard MP et al (2003) Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasion. J Neurosurg 98:1084-1093 (Pubitemid 36460901)
11. Blaheta RA, Hundemer M, Mayer G et al (2002) Expression level of neural cell adhesion molecule (NCAM) inversely correlates with the ability of neuroblastoma cells to adhere to endothelium in vitro. Cell Commun Adhes 9:131-147 (Pubitemid 36024631)
12. Blaheta RA, Daher FH, Michaelis M et al (2006) Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression. BMC Cancer 6:294
13. Lynch DF Jr, Hassen W, Clements MA, Schellhammer PF, Wright GL Jr (1997) Serum levels of endothelial and neural cell adhesion molecules in prostate cancer. Prostate 32:214-220 (Pubitemid 27337956)
14. Gluer S, Schelp C, Madry N, von Schweinitz D, Eckhardt M, Gerardy-Schahn R (1998) Serum polysialylated neural cell adhesion molecule in childhood neuroblastoma. Br J Cancer 78:106-110 (Pubitemid 28276778)
15. Todaro L, Christiansen S, Varela M et al (2007) Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors. J Neurooncol 83:135-144 (Pubitemid 46784986)
16. Bataille R, Jego G, Robillard N et al (2006) The phenotype of normal, reactive and malignant plasma cells. Identification of "many and multiple myelomas" and of new targets for myeloma therapy. Haematologica 91:1234-1240
17. Ely SA, Knowles DM (2002) Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol 160:1293-1299 (Pubitemid 34411633)
18. Martin P, Santon A, Bellas C (2004) Neural cell adhesion molecule expression in plasma cells in bone marrow biopsies and aspirates allows discrimination between multiple myeloma, monoclonal gammopathy of uncertain significance and polyclonal plasmacytosis. Histopathology 44:375-380 (Pubitemid 38491305)
19. Rawstron A, Barrans S, Blythe D et al (1999) Distribution of myeloma plasma cells in peripheral blood and bone marrow correlates with CD56 expression. Br J Haematol 104:138-143 (Pubitemid 29037032)
20. Sahara N, Takeshita A (2004) Prognostic significance of surface markers expressed in multiple myeloma: CD56 and other antigens. Leuk Lymphoma 45:61-65 (Pubitemid 38181394)
21. Novotny JR, Nuckel H, Duhrsen U (2006) Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. Eur J Haematol 76:299-308 (Pubitemid 43362938)
22. Raspadori D, Damiani D, Lenoci M et al (2001) CD56 antigenic expression in acute myeloid leukemia identifies patients with poor clinical prognosis. Leukemia 15:1161-1164 (Pubitemid 32776438)
23. Yang DH, Lee JJ, Mun YC et al (2007) Predictable prognostic factor of CD56 expression in patients with acute myeloid leukemia with t(8:21) after high dose cytarabine or allogeneic hematopoietic stem cell transplantation. Am J Hematol 82:1-5
24. Gattenloehner S, Chuvpilo S, Langebrake C et al (2007) Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression. Blood 110:2027-2033 (Pubitemid 47443919)
25. Yamagata T, Maki K, Mitani K (2005) Runx1/AML1 in normal and abnormal hematopoiesis. Int J Hematol 82:1-8 (Pubitemid 41512192)
26. Roesler J, Srivatsan E, Moatamed F, Peters J, Livingston EH (1997) Tumor suppressor activity of neural cell adhesion molecule in colon carcinoma. Am J Surg 174:251-257 (Pubitemid 27415349)
27. Huerta S, Srivatsan ES, Venkatesan N et al (2001) Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule. Surgery 130:834-843 (Pubitemid 33022391)
28. Kameda K, Shimada H, Ishikawa T et al (1999) Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion. Cancer Lett 137:201-207 (Pubitemid 29179464)
29. Tezel E, Kawase Y, Takeda S, Oshima K, Nakao A (2001) Expression of neural cell adhesion molecule in pancreatic cancer. Pancreas 22:122-125 (Pubitemid 32179165)
30. Naito Y, Kinoshita H, Okabe Y et al (2006) CD56 (NCAM) expression in pancreatic carcinoma and the surrounding pancreatic tissue. Kurume Med J 53:59-62 (Pubitemid 46456070)
31. Deramaudt TB, Takaoka M, Upadhyay R et al (2006) N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption. Mol Cell Biol 26:4185-4200 (Pubitemid 43788020)
32. Vargas F, Tolosa E, Sospedra M et al (1994) Characterization of neural cell adhesion molecule (NCAM) expression in thyroid follicular cells: induction by cytokines and over-expression in autoimmune glands. Clin Exp Immunol 98:478-488 (Pubitemid 24374735)
33. Zeromski J, Bagnasco M, Paolieri F, Dworacki G (1992) Expression of CD56 (NKH-1) differentiation antigen in human thyroid epithelium. Clin Exp Immunol 89:474-478
34. Satoh F, Umemura S, Yasuda M, Osamura RY (2001) Neuroendocrine marker expression in thyroid epithelial tumors. Endocr Pathol 12:291-299 (Pubitemid 34066750)
35. Scarpino S, Di Napoli A, Melotti F, Talerico C, Cancrini A, Ruco L (2007) Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF-D production by tumour cells. J Pathol 212:411-419 (Pubitemid 47099018)
36. Onganer PU, Seckl MJ, Djamgoz MB (2005) Neuronal characteristics of small-cell lung cancer. Br J Cancer 93:1197-1201 (Pubitemid 41679403)
37. Niklinski J, Furman M (1995) Clinical tumour markers in lung cancer. Eur J Cancer Prev 4:129-138
38. Miyahara R, Tanaka F, Nakagawa T, Matsuoka K, Isii K, Wada H (2001) Expression of neural cell adhesion molecules (polysialylated form of neural cell adhesion molecule and L1-cell adhesion molecule) on resected small cell lung cancer specimens: in relation to proliferation state. J Surg Oncol 77:49-54 (Pubitemid 32382019)
39. Ornadel D, Ledermann JA, Eagle K et al (1998) Biodistribution of a radiolabelled monoclonal antibody NY3D11 recognizing the neural cell adhesion molecule in tumour xenografts and patients with small-cell lung cancer. Br J Cancer 77:103-109 (Pubitemid 28029780)
40. Hosono MN, Hosono M, Mishra AK et al (2000) Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer. Ann Nucl Med 14:173-179 (Pubitemid 30485351)
41. Michalides R, Kwa B, Springall D et al (1994) NCAM and lung cancer. Int J Cancer Suppl 8:34-37 (Pubitemid 24188954)
42. Johnson BE, Kelley MJ (1998) Autocrine growth factors and neuroendocrine markers in the development of small-cell lung cancer. Oncology (Williston Park) 12:11-14 (Pubitemid 128527952)
43. Murray N, Salgia R, Fossella FV (2004) Targeted molecules in small cell lung cancer. Semin Oncol 31:106-111 (Pubitemid 38241028)
44. Yu A, Choi J, Ohno K, Levin B, Rom WN, Meruelo D (2000) Specific cell targeting for delivery of toxins into small-cell lung cancer using a streptavidin fusion protein complex. DNA Cell Biol 19:383-388 (Pubitemid 30618505)
45. Zangemeister-Wittke U, Collinson AR, Frosch B, Waibel R, Schenker T, Stahel RA (1994) Immunotoxins recognising a new epitope on the neural cell adhesion molecule have potent cytotoxic effects against small cell lung cancer. Br J Cancer 69:32-39 (Pubitemid 24021819)
46. Hanahan D (1985) Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122 (Pubitemid 15064530)
47. Lahr G, Mayerhofer A, Bucher S, Barthels D, Wille W, Gratzl M (1993) Neural cell adhesion molecules in rat endocrine tissues and tumor cells: distribution and molecular analysis. Endocrinology 132:1207-1217 (Pubitemid 23068639)
48. Moller CJ, Christgau S, Williamson MR et al (1992) Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol 6:1332-1342
49. Cavallaro U, Niedermeyer J, Fuxa M, Christofori G (2001) N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol 3:650-657 (Pubitemid 32624421)
50. Perl AK, Dahl U, Wilgenbus P, Cremer H, Semb H, Christofori G (1999) Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells. Nat Med 5:286-291 (Pubitemid 29124363)
51. Crnic I, Strittmatter K, Cavallaro U et al (2004) Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Res 64:8630-8638 (Pubitemid 39552076)
52. Cavallaro U, Christofori G (2001) Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. Biochim Biophys Acta 1552:39-45 (Pubitemid 34066627)
53. Alpaugh ML, Tomlinson JS, Ye Y, Barsky SH (2002) Relationship of sialyl-Lewis(x/a) underexpression and E-cadherin overexpression in the lymphovascular embolus of inflammatory breast carcinoma. Am J Pathol 161:619-628 (Pubitemid 36142170)
54. Xian X, Hakansson J, Stahlberg A et al (2006) Pericytes limit tumor cell metastasis. J Clin Invest 116:642-651 (Pubitemid 43326873)
55. Mayerhofer A, Spanel-Borowski K, Watkins S, Gratzl M (1992) Cultured microvascular endothelial cells derived from the bovine corpus luteum possess NCAM-140. Exp Cell Res 201:545-548
56. Foets BJ, van den Oord JJ, Volpes R, Missotten L (1992) In situ immunohistochemical analysis of cell adhesion molecules on human corneal endothelial cells. Br J Ophthalmol 76:205-209
57. Mizutani H, Roswit W, Hemperly J et al (1994) Human dermal microvascular endothelial cells express the 140-kD isoform of neural cell adhesion molecule. Biochem Biophys Res Commun 203:686-693
58. Gingras MC, Roussel E, Bruner JM, Branch CD, Moser RP (1995) Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue. J Neuroimmunol 57:143-153
59. Bekker MN, Arkesteijn JB, van den Akker NM et al (2005) Increased NCAM expression and vascular development in trisomy 16 mouse embryos: relationship with nuchal translucency. Pediatr Res 58:1222-1227
60. Bussolati B, Deambrosis I, Russo S, Deregibus MC, Camussi G (2003) Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J 17:1159-1161
61. Geninatti Crich S, Bussolati B, Tei L et al (2006) Magnetic resonance visualization of tumor angiogenesis by targeting neural cell adhesion molecules with the highly sensitive gadolinium-loaded apoferritin probe. Cancer Res 66:9196-9201 (Pubitemid 44521140)
62. Bussolati B, Grange C, Bruno S et al (2006) Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillarylike structures. Exp Cell Res 312:913-924
63. Williams EJ, Furness J, Walsh FS, Doherty P (1994) Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron 13:583-594 (Pubitemid 24300164)
64. Francavilla C, Loeffler S, Piccini D, Kren A, Christofori G, Cavallaro U (2007) Neural cell adhesion molecule regulates the cellular response to fibroblast growth factor. J Cell Sci 120:4388-4394
65. Kiselyov VV, Skladchikova G, Hinsby AM et al (2003) Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure (Camb) 11:691-701 (Pubitemid 37281184)
66. Grose R, Dickson C (2005) Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev 16:179-186 (Pubitemid 40616115)
67. Jensen M, Berthold F (2007) Targeting the neural cell adhesion molecule in cancer. Cancer Lett 258:9-21 (Pubitemid 47600500)
68. Gluer S, Schelp C, Gerardy-Schahn R, von Schweinitz D (1998) Polysialylated neural cell adhesion molecule as a marker for differential diagnosis in pediatric tumors. J Pediatr Surg 33:1516-1520 (Pubitemid 28480913)
69. Zeromski J, Biczysko M, Stajgis P, Lawniczak M, Biczysko W (1999) CD56(NCAM) antigen in glandular epithelium of human thyroid: light microscopic and ultrastructural study. Folia Histochem Cytobiol 37:11-17 (Pubitemid 29067624)
70. Zeromski J, Dworacki G, Jenek J et al (1999) Protein and mRNA expression of CD56/NCAM on follicular epithelial cells of the human thyroid. Int J Immunopathol Pharmacol 12:23-30 (Pubitemid 29178893)