Papillary carcinoma of the thyroid: low expression of NCAM (CD56) is associated with downregulation of VEGF-D production by tumour cells

Journal of Pathology

Volumn 212, Issue 4, 2007, Pages 411-419

  Scarpino, Stefania ^a   Di Napoli, A ^a   Melotti, F ^a   Talerico, C ^a   Cancrini, A ^a   Ruco, L ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

NCAM; Podoplanin; Thyroid cancer; Thyroid papillary carcinoma; Thyroid tumours

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; PODOPLANIN; RNA; VASCULOTROPIN C; VASCULOTROPIN D;

ARTICLE; CANCER CELL; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; IMMUNOPRECIPITATION; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; THYROID PAPILLARY CARCINOMA; TUMOR VASCULARIZATION; WESTERN BLOTTING;

ADULT; ANTIGENS, CD56; CARCINOMA, PAPILLARY; CELL ADHESION; DOWN-REGULATION; GENE SILENCING; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; THYROID NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 34547095764     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2183     Document Type: Article

References (23)

1. Crossin KL, Krushel LA. Cellular signalling by neural cell adhesion molecules of the immunoglobulin superfamily. Dev Dyn 2000; 218:260-279.
2. Panicker AK, Buhusi M, Thelen K, Maness PF. Cellular signalling mechanisms of neural cell adhesion molecules. Front Biosci 2003; 8:900-911.
3. Fogar P, Basso D, Pasquali C, De Paoli M, Sperti C, Roveroni G, et al. Neural cell adhesion molecules (N-CAM) in gastrointestinal neoplasias. Anticancer Res 1997;17:1227-1230.
4. Huerta S, Srivatsan ES, Venkatesan N, Peters J, Moatamed F, Renner S, et al. Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecules. Surgery 2001; 130:834-843.
5. Zeromski J, Lawniczak M, Galbas K, Jenek R, Golusinnski P. Expression of CD56/N-CAM antigen and some other adhesion molecules in various human endocrine glands. Folia Histoc Cytobiol 1998;36:119-125.
6. Zeromski J, Dworacki G, Jenek J, Niemir Z, Jezewska E, Jenek R, et al. Protein and mRNA expression of CD56/NCAM on follicular epithelial cells of the human thyroid. Int J Immunopathol Pharmacol 1999; 12:23-30.
7. Satoh F, Umemura S, Yasuda M, Osamura RY. Neuroendocrine, marker expression in thyroid epithelial tumors. Endocr Pathol 2001; 12:291-299.
8. Cavallaro U, Niedermayer J, Fuxa M, Christofori G. N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nature Cell Biol 2001;3:650-657.
9. Crnic I, Strittmatter K, Cavallaro U, Kopfstein L, Jussila L, Alitalo K, et al. Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Res 2004; 64:8630-8638.
10. Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002;1:219-227.
11. McColl BK, Stacker SA, Achen MG. Molecular regulation of the VEGF family inducers of angiogenesis and lymphangiogenesis. APMIS 2004; 112:463-480.
12. Breiteneder-Geleff S, Matsui K, Soleiman A, Meraner P, Poczewski H, Kalt R, et al. Podoplanin, novel 43-kD membrane protein of glomerular epithelial cells, is down regulated in puromycin nephrosis. Am J Pathol 1997;151:1141-1152.
13. Al-Rawi MAA, Mansel RE, Jiang WG. Lymphangiogenesis and its role in cancer. Histol Histopathol 2005;20:283-298.
14. Yasuoka H, Nakamura Y, Zuo H, Tang W, Takamura Y, Miyauchi A, et al. VEGF-D expression and lymph vessels play an important role for lymph node metastasis in papillary thyroid carcinoma. Mod Pathol 2005; 18:1127-1133.
15. Reis-Filho JS, Schmitt FC. Lymphangiogenesis in tumors: what do we know? Microsc Res Tech 2003;60:171-180.
16. Nakamura Y, Yasoka H, Tsujimoto M, Imabun S, Nakahara M, Nakao K, et al. Lymph vessel density correlates with nodal status, VEGF-C expression and prognosis in breast cancer. Breast Cancer Res 2005;91:125-132.
17. Al-Rawi MAA, Mansel RE, Jiang WG. Molecular and cellular mechanisms of lymphangiogenesis. EJSO 2005;31:117-121.
18. Tanaka K, Kurebayashi J, Sonoo H, Otsuki T, Yamamoto Y, Ohkubo S, et al. Expression of vascular endothelial growth factor family messenger RNA in diseased thyroid tissues. Surg Today 2002; 32:761-768.
19. Orlandini M, Oliviero S. In fibroblasts VEGF-D expression is induced by cell-cell contact mediated by cadherin-11. JBC 2001; 9:6576-6581.
20. Orlandini M, Semboloni S, Oliviero S. β-catenin inversely regulates vascular endothelial growth factor-D mRNA stability. JBC 2003; 45:44650-44656.
21. Chilov D, Kukk E, Taira S, Jeltsch M, Kaukonen J, Palotie A, et al. Genomic organization of human and mouse genes for vascular endothelial growth factor C. JBC 1997;272:25176-25183.
22. Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 2002;13:413-421.
23. Ristimaki A, Narko K, Enholm B, Joukov V, Alitalo K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. JBC 1998; 273:8413-8418.