Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089

Journal of Bioscience and Bioengineering

Volumn 109, Issue 5, 2010, Pages 459-465

  Fukuda, Koji ^a   Tamura, Takashi ^a   Ito, Hideyuki ^b   Yamamoto, Sayaka ^a   Ochi, Kozo ^c   Inagaki, Kenji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

^c NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Rifampicin resistance; rpoB gene; Secondary metabolism; Sinefungin; Streptomyces incarnatus

Indexed keywords

AMINO ACID SUBSTITUTION; ANTI-FUNGAL; ANTIBIOTIC PRODUCTION; DNA SEQUENCING; MEDIUM OPTIMIZATION; MOLECULAR CLONING; MUTANT STRAIN; PRODUCTION ENHANCEMENT; PRODUCTION IMPROVEMENT; RESISTANT STRAINS; RESTING CELLS; RNA POLYMERASE; RPOB GENE; S. COELICOLOR; SECONDARY METABOLISM; SINGLE MUTATION; SPORE FORMATION; STRAIN IMPROVEMENT; UP-REGULATION; UV IRRADIATION;

AMINO ACIDS; ANTIBIOTICS; BIOMOLECULES; CLONING; OPTIMIZATION; ORGANIC ACIDS; RNA; SULFUR COMPOUNDS; UREA;

METABOLISM;

ACTINORHODINE; ANTIFUNGAL AGENT; ANTITRYPANOSOMAL AGENT; ARGININE; ORNITHINE; RIFAMPICIN; RNA POLYMERASE; SINEFUNGIN;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA SEQUENCE; DRUG MANUFACTURE; DRUG SYNTHESIS; FUNGAL GENE; FUNGAL STRAIN; FUNGUS GROWTH; GENE MUTATION; MELANOGENESIS; MOLECULAR CLOCK; MORPHOLOGY; NONHUMAN; POLYMERIZATION; STREPTOMYCES; STREPTOMYCES COELICOLOR; STREPTOMYCES INCARNATUS; TRANSCRIPTION REGULATION; ULTRAVIOLET IRRADIATION; UPREGULATION;

ADENOSINE; ANTIFUNGAL AGENTS; ANTIPROTOZOAL AGENTS; BACTERIAL PROTEINS; CELL CULTURE TECHNIQUES; GENETIC ENHANCEMENT; MUTAGENESIS, SITE-DIRECTED; SPECIES SPECIFICITY; STREPTOMYCES; TRYPANOSOMA;

STREPTOMYCES; STREPTOMYCES COELICOLOR;

EID: 77949893212     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.10.017     Document Type: Article

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