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Volumn 6, Issue 1, 2010, Pages 51-61

Endocrine therapy for advanced breast cancer: Beyond tamoxifen and aromatase inhibitors

Author keywords

Androgens; Estrogens; Fulvestrant; Megestrol acetate; Progestins antagonists; Sulfatase inhibitor

Indexed keywords

11BETA (4 ACETYLPHENYL) 17BETA HYDROXY 17ALPHA (1,1,2,2,2 PENTAFLUOROETHYL)ESTRA 4,9 DIEN 3 ONE; 17ALPHA ACETOXY 11BETA (4 DIMETHYLAMINOPHENYL) 21 METHOXY 19 NORPREGNA 4,9 DIENE 3,20 DIONE; ANASTROZOLE; ANDROGEN; ANDROSTANOLONE; ANTIGESTAGEN; AROMATASE INHIBITOR; ASOPRISNIL; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ETHINYLESTRADIOL; EXEMESTANE; FLUOXYMESTERONE; FULVESTRANT; GESTAGEN; LETROZOLE; MEDROXYPROGESTERONE; MEGESTROL ACETATE; MIFEPRISTONE; OCTREOTIDE; ONAPRISTONE; PRASTERONE; PROGESTERONE; SOMATOSTATIN; TAMOXIFEN; TIPIFARNIB; TRASTUZUMAB; ULIPRISTAL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77949889768     PISSN: 15733947     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339410790596498     Document Type: Review
Times cited : (2)

References (86)
  • 1
    • 0034669484 scopus 로고    scopus 로고
    • Anastrozole is superior to Tam as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial
    • Nabholtz JM, Buzdar AU, Pollak M, et al. Anastrozole is superior to Tam as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. J Clin Oncol 2000; 18: 3758-7.
    • (2000) J Clin Oncol , vol.18 , pp. 3758-3767
    • Nabholtz, J.M.1    Buzdar, A.U.2    Pollak, M.3
  • 2
    • 0034669435 scopus 로고    scopus 로고
    • Anastrozole versus Tam as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the Tam or Arimidex randomized group efficacy and tolerability study
    • Bonneterre J, Thurlimann B, Robertson JFR, et al. Anastrozole versus Tam as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tam or Arimidex randomized group efficacy and tolerability study. J Clin Oncol 2000; 18: 3748-7.
    • (2000) J Clin Oncol , vol.18 , pp. 3748-3757
    • Bonneterre, J.1    Thurlimann, B.2    Robertson, J.F.R.3
  • 3
    • 0001946288 scopus 로고    scopus 로고
    • Exemestane (Aromasin) is active and well tolerated as first-line hormonal therapy (HT) of metastatic breast cancer (MBC) patients (Pts): Results of a randomized phase II trial
    • Paridaens R, Dirix LY, Beex L, et al. Exemestane (Aromasin) is active and well tolerated as first-line hormonal therapy (HT) of metastatic breast cancer (MBC) patients (Pts): results of a randomized phase II trial. Proc Am Soc Clin Oncol 2000; 19: 316.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 316
    • Paridaens, R.1    Dirix, L.Y.2    Beex, L.3
  • 4
    • 0343584508 scopus 로고    scopus 로고
    • Superior efficacy of letrozole versus Tam as first-line therapy for postmenopausal women with advanced breast cancer: Results of a phase III study of the International Letrozole Breast Cancer Group
    • Mouridsen HT, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus Tam as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol 2001; 19: 2596-6.
    • (2001) J Clin Oncol , vol.19 , pp. 2596-2596
    • Mouridsen, H.T.1    Gershanovich, M.2    Sun, Y.3
  • 5
    • 0035884408 scopus 로고    scopus 로고
    • Robertson JF, Nicholson RI, Bundred NJ, et al. Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) -nonylestra-1,3,5, (10)-triene-3,17betadiol (Faslodex) versus Tam in postmenopausal women with primary breast cancer. Cancer Res 2001; 61: 6739-6.
    • Robertson JF, Nicholson RI, Bundred NJ, et al. Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) -nonylestra-1,3,5, (10)-triene-3,17betadiol (Faslodex) versus Tam in postmenopausal women with primary breast cancer. Cancer Res 2001; 61: 6739-6.
  • 6
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JFR, Quaresma Albano J, et al. Fulvestrant, formerly ICI 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002; 16: 3396-3.
    • (2002) J Clin Oncol , vol.16 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.R.2    Quaresma Albano, J.3
  • 7
    • 0037102126 scopus 로고    scopus 로고
    • Double-blind randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: Results of a North American trial
    • Osborne CK, Pippen J, Jones SE, et al. Double-blind randomized trial comparing the efficacy and tolerability of fulvestrant versus anastrozole in postmenopausal women with advanced breast cancer progressing on prior endocrine therapy: results of a North American trial. J Clin Oncol 2002; 20: 3386-5.
    • (2002) J Clin Oncol , vol.20 , pp. 3386-3395
    • Osborne, C.K.1    Pippen, J.2    Jones, S.E.3
  • 8
    • 0038683988 scopus 로고    scopus 로고
    • Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: A prospective combined analysis of two multicenter trials
    • Robertson JF, Osborne CK, Howell A, et al. Fulvestrant versus anastrozole for the treatment of advanced breast carcinoma in postmenopausal women: a prospective combined analysis of two multicenter trials. Cancer 2003; 98: 229-8.
    • (2003) Cancer , vol.98 , pp. 229-238
    • Robertson, J.F.1    Osborne, C.K.2    Howell, A.3
  • 9
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus Tam for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: A multinational, double-blind randomized trial
    • Howell A, Robertson JF, Abram P, et al. Comparison of fulvestrant versus Tam for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind randomized trial. J Clin Oncol 2004; 22: 1605-3.
    • (2004) J Clin Oncol , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3
  • 10
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: Results from EFECT
    • Chia S, Gradishar W, Mauriac L, et al.Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptor-positive, advanced breast cancer: results from EFECT.J Clin Oncol 2008; 26: 1664-0.
    • (2008) J Clin Oncol , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3
  • 11
    • 1842633460 scopus 로고    scopus 로고
    • Fulvestrant: Pharmacokinetics and pharmacology
    • Robertson JF, Harrison M. Fulvestrant: pharmacokinetics and pharmacology. Br J Cancer 2004; 90(Suppl 1): S7-S10.
    • (2004) Br J Cancer , vol.90 , Issue.SUPPL. 1
    • Robertson, J.F.1    Harrison, M.2
  • 12
    • 55549137832 scopus 로고    scopus 로고
    • Fulvestrant 500 mg vs 250 mg: First results from NEWEST, a randomized, phase II neoadjuvant trial in postmenopausal women with locally advanced, estrogen receptor-positive breast cancer
    • abstr 589
    • Kuter I, Hegg R, Singer CF, et al. Fulvestrant 500 mg vs 250 mg: First results from NEWEST, a randomized, phase II neoadjuvant trial in postmenopausal women with locally advanced, estrogen receptor-positive breast cancer. Breast Cancer Res Treat 106: 7; 2007 abstr 589.
    • (2007) Breast Cancer Res Treat , vol.106 , pp. 7
    • Kuter, I.1    Hegg, R.2    Singer, C.F.3
  • 13
    • 77949903661 scopus 로고    scopus 로고
    • Di Leo A, Jerusalem G, Petruzelka L, et al. CONFIRM: A phase III, Randomized, Parallel-Group trial comparing Fulvestrant 250mg vs Fulvestrant 500mg in postenopausal women with estrogen receptor positive advanced breast cancer. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 25.
    • Di Leo A, Jerusalem G, Petruzelka L, et al. CONFIRM: A phase III, Randomized, Parallel-Group trial comparing Fulvestrant 250mg vs Fulvestrant 500mg in postenopausal women with estrogen receptor positive advanced breast cancer. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 25.
  • 14
    • 33846023025 scopus 로고    scopus 로고
    • Effects of fulvestrant 250mg in premenopausal women with oestrogen receptor-positive primary breast cancer
    • Robertson JF, Semiglazov V, Nemsadze G. Effects of fulvestrant 250mg in premenopausal women with oestrogen receptor-positive primary breast cancer. Eur J Cancer 2007; 43: 64-7.
    • (2007) Eur J Cancer , vol.43 , pp. 64-67
    • Robertson, J.F.1    Semiglazov, V.2    Nemsadze, G.3
  • 15
    • 38749129651 scopus 로고    scopus 로고
    • Effects of fulvestrant 750mg in premenopausal women with oestrogen-receptor-positive primary breast cancer.Eur
    • Young OE, Renshaw L, Macaskill EJ, et al. Effects of fulvestrant 750mg in premenopausal women with oestrogen-receptor-positive primary breast cancer.Eur J Cancer 2008; 44: 391-9.
    • (2008) J Cancer , vol.44 , pp. 391-399
    • Young, O.E.1    Renshaw, L.2    Macaskill, E.J.3
  • 16
    • 44849089392 scopus 로고    scopus 로고
    • Combination of Anastrozole with Fulvestrant in the Intratumoral Aromatase Xenograft Model
    • Macedo LF, Sabnis GJ, Goloubeva OG, et al. Combination of Anastrozole with Fulvestrant in the Intratumoral Aromatase Xenograft Model. Cancer Res 2008; 68: 3516-22.
    • (2008) Cancer Res , vol.68 , pp. 3516-3522
    • Macedo, L.F.1    Sabnis, G.J.2    Goloubeva, O.G.3
  • 17
    • 77949880683 scopus 로고    scopus 로고
    • Bergh J, Jonsson PE, Lidbrink E, et al. First result from FACT- An open label, randomized phase III study investigating loading dose of fulvestrant combined anastrozole versus anastrozole at first relapse in hormone receptor positive breast cancer. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 23.
    • Bergh J, Jonsson PE, Lidbrink E, et al. First result from FACT- An open label, randomized phase III study investigating loading dose of fulvestrant combined anastrozole versus anastrozole at first relapse in hormone receptor positive breast cancer. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 23.
  • 18
    • 77949904221 scopus 로고    scopus 로고
    • Robertson JFR, Dixon JM, Sibbering DM, et al. Tumor biomarker changes following pre-surgical treatment with 500 mg Fulvestrant plus Anastrozole versus 500 mg Fulvestrant alone and 1 mg Anastrozole alone. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 24.
    • Robertson JFR, Dixon JM, Sibbering DM, et al. Tumor biomarker changes following pre-surgical treatment with 500 mg Fulvestrant plus Anastrozole versus 500 mg Fulvestrant alone and 1 mg Anastrozole alone. Cancer Res 2009; 69(Suppl.)(24): Abstract nr 24.
  • 19
    • 27644597480 scopus 로고    scopus 로고
    • A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer
    • De Laurentiis M, Arpino G, Massarelli E, et al. A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer. Clin Cancer Res 2005; 11: 4741-8.
    • (2005) Clin Cancer Res , vol.11 , pp. 4741-4748
    • De Laurentiis, M.1    Arpino, G.2    Massarelli, E.3
  • 20
    • 77949876367 scopus 로고    scopus 로고
    • Christos LP, Sparano JA, Hershman DL, et al. Phase II study of the farnesyl transferase inhibitor tipifarnib plus fulvestrant in postmenopausal patients with hormone receptor-positive breast cancer: New York Cancer Consortium Trial P6205. J Clin Oncol (Meeting Abstracts) 2007 25: 18s.
    • Christos LP, Sparano JA, Hershman DL, et al. Phase II study of the farnesyl transferase inhibitor tipifarnib plus fulvestrant in postmenopausal patients with hormone receptor-positive breast cancer: New York Cancer Consortium Trial P6205. J Clin Oncol (Meeting Abstracts) 2007 25: 18s.
  • 21
    • 1842830729 scopus 로고    scopus 로고
    • Improved antitumor therapy with Herceptin and Faslodex for dual targeting of HER-2 and estrogen receptor signalling pathways in human breast cancers with overexpression of HER-2/neu gene
    • Pietras RJ, Marquez DC, Chen HW, et al. Improved antitumor therapy with Herceptin and Faslodex for dual targeting of HER-2 and estrogen receptor signalling pathways in human breast cancers with overexpression of HER-2/neu gene. Breast Cancer Res Treat 2003; 82(suppl 1): S12.
    • (2003) Breast Cancer Res Treat , vol.82 , Issue.SUPPL. 1
    • Pietras, R.J.1    Marquez, D.C.2    Chen, H.W.3
  • 22
    • 27144494936 scopus 로고    scopus 로고
    • Fulvestrant ('Faslodex'): Clinical experience from the Compassionate Use Programme
    • Steger GG, Gips M, Simon SD, et al. Fulvestrant ('Faslodex'): Clinical experience from the Compassionate Use Programme. Cancer Treat Rev 2005; 31(suppl 2): S10-S16.
    • (2005) Cancer Treat Rev , vol.31 , Issue.SUPPL. 2
    • Steger, G.G.1    Gips, M.2    Simon, S.D.3
  • 23
    • 77949908385 scopus 로고    scopus 로고
    • Robertson JF, Steger G, Neven P, Barni S. Fulvestrant in the treatment of HER2-positive advanced breast cancer (ABC). J Clin Oncol (Meeting Abstracts) 2007 25: 18s.
    • Robertson JF, Steger G, Neven P, Barni S. Fulvestrant in the treatment of HER2-positive advanced breast cancer (ABC). J Clin Oncol (Meeting Abstracts) 2007 25: 18s.
  • 24
    • 0023867603 scopus 로고
    • Proliferative and secretory activity in human breast during natural and artificial menstrual cycles
    • Going JJ, Anderson TJ, Battersby S, Macintyre CC. Proliferative and secretory activity in human breast during natural and artificial menstrual cycles. Am J Pathol 1988; 130: 193-4.
    • (1988) Am J Pathol , vol.130 , pp. 193-194
    • Going, J.J.1    Anderson, T.J.2    Battersby, S.3    Macintyre, C.C.4
  • 26
    • 33845606315 scopus 로고    scopus 로고
    • Clinical applications of mifepristone.Gynecol
    • Tang OS, Ho PC. Clinical applications of mifepristone.Gynecol Endocrinol 2006; 22: 655-9.
    • (2006) Endocrinol , vol.22 , pp. 655-659
    • Tang, O.S.1    Ho, P.C.2
  • 27
    • 0019443088 scopus 로고    scopus 로고
    • Belanger A, Philibert D, Teutsch G. Regio and Stereospecific synthesis of 11 beta-substituted 19-norsteroids. Infl uence of 11 betasubstitution on progesterone receptor affi nity - (1).Steroids 1981 ; 37 : 361 -82.
    • Belanger A, Philibert D, Teutsch G. Regio and Stereospecific synthesis of 11 beta-substituted 19-norsteroids. Infl uence of 11 betasubstitution on progesterone receptor affi nity - (1).Steroids 1981 ; 37 : 361 -82.
  • 28
    • 0024461465 scopus 로고
    • Endocrine and antitumor effects of combined treatment with an antiprogestin and antiestrogen or luteinizing hormone-releasing hormone agonist in female rats bearing mammary tumors
    • Bakker GH, Setyono-Han B, Portengen H, De Jong FH, Foekens JA, Klijin M. Endocrine and antitumor effects of combined treatment with an antiprogestin and antiestrogen or luteinizing hormone-releasing hormone agonist in female rats bearing mammary tumors. Endocrinology 1989; 125: 1593-8.
    • (1989) Endocrinology , vol.125 , pp. 1593-1598
    • Bakker, G.H.1    Setyono-Han, B.2    Portengen, H.3    De Jong, F.H.4    Foekens, J.A.5    Klijin, M.6
  • 29
    • 0023193251 scopus 로고
    • Reversal of the antitumor effects of Tam by progesterone in the 7, 12-dimethylbenzanthracene-induced rat mammary carcinoma model
    • Robinson, S.P., and Jordan, V.C. Reversal of the antitumor effects of Tam by progesterone in the 7, 12-dimethylbenzanthracene-induced rat mammary carcinoma model. Cancer Res 1987; 47: 5386.
    • (1987) Cancer Res , vol.47 , pp. 5386
    • Robinson, S.P.1    Jordan, V.C.2
  • 30
    • 33845315093 scopus 로고    scopus 로고
    • Prevention of Brca1-Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist
    • Poole AJ, Li Y, Kim Y, Lin SC, Lee WH, Lee EY. Prevention of Brca1-Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist. Science 2006; 314: 1467-70.
    • (2006) Science , vol.314 , pp. 1467-1470
    • Poole, A.J.1    Li, Y.2    Kim, Y.3    Lin, S.C.4    Lee, W.H.5    Lee, E.Y.6
  • 32
    • 0024319047 scopus 로고
    • Antiprogestins, a New Form of Endocrine Therapy for Human Breast Cancer
    • Klij G, de Jong F, Bakker G, et al. Antiprogestins, a New Form of Endocrine Therapy for Human Breast Cancer. Cancer Res 1989; 49: 2851-6.
    • (1989) Cancer Res , vol.49 , pp. 2851-2856
    • Klij, G.1    de Jong, F.2    Bakker, G.3
  • 33
    • 0033082357 scopus 로고    scopus 로고
    • Onapristone, a progesterone receptorantagonist, as fi rst-line therapy in primary breast cancer
    • Robertson JF, Willsher PC, Winterbottom L, et al. Onapristone, a progesterone receptorantagonist, as fi rst-line therapy in primary breast cancer. Eur J Cancer 1999; 35: 214 -8.
    • (1999) Eur J Cancer , vol.35 , pp. 214-218
    • Robertson, J.F.1    Willsher, P.C.2    Winterbottom, L.3
  • 34
    • 42949179500 scopus 로고    scopus 로고
    • CDB-2914 for uterine leiomyomata treatment: A randomized controlled trial
    • Levens ED, Potlog-Nahari C, Armstrong AY, et al. CDB-2914 for uterine leiomyomata treatment: a randomized controlled trial. Obstet Gynecol 2008; 111: 1129-36.
    • (2008) Obstet Gynecol , vol.111 , pp. 1129-1136
    • Levens, E.D.1    Potlog-Nahari, C.2    Armstrong, A.Y.3
  • 35
    • 34447305522 scopus 로고    scopus 로고
    • The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata
    • Williams AR, Critchley HO, Osei J, et al. The effects of the selective progesterone receptor modulator asoprisnil on the morphology of uterine tissues after 3 months treatment in patients with symptomatic uterine leiomyomata. Hum Reprod. 2007; 22: 1696.
    • (2007) Hum Reprod , vol.22 , pp. 1696
    • Williams, A.R.1    Critchley, H.O.2    Osei, J.3
  • 36
    • 0028853923 scopus 로고
    • Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells
    • Masamura S, Santner SJ, Heitjan DF, et al. Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J Clin Endocrinol Metab 1995; 80: 2918-2925.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2918-2925
    • Masamura, S.1    Santner, S.J.2    Heitjan, D.F.3
  • 37
    • 0035930095 scopus 로고    scopus 로고
    • Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17β-estradiol
    • Song RX-D, Mor G, Naftolin F, et al. Effect of long-term estrogen deprivation on apoptotic responses of breast cancer cells to 17β-estradiol. J Natl Cancer Inst 2001; 93: 1714-23.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1714-1723
    • Song, R.X.-D.1    Mor, G.2    Naftolin, F.3
  • 38
    • 28944444552 scopus 로고    scopus 로고
    • Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation
    • Lewis JS, Meeke K, Osipo C, et al. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst 2005; 97: 1746-59.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1746-1759
    • Lewis, J.S.1    Meeke, K.2    Osipo, C.3
  • 39
    • 0034066141 scopus 로고    scopus 로고
    • Antitumor action of physiological estradiol on Tam-stimulated breast tumors grown in athymic mice
    • Yao K, Lee ES, Bentrem DJ, et al: Antitumor action of physiological estradiol on Tam-stimulated breast tumors grown in athymic mice. Clin Cancer Res 2000; 6: 2028-36.
    • (2000) Clin Cancer Res , vol.6 , pp. 2028-2036
    • Yao, K.1    Lee, E.S.2    Bentrem, D.J.3
  • 40
    • 0019382847 scopus 로고
    • Randomized clinical trial of diethylstilstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer
    • Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med 1981; 304: 16-21.
    • (1981) N Engl J Med , vol.304 , pp. 16-21
    • Ingle, J.N.1    Ahmann, D.L.2    Green, S.J.3
  • 41
    • 0022478410 scopus 로고
    • Randomized comparison of Tam versus diethylstilbestrol in estrogen receptorpositive or -unknown metastatic breast cancer: A Southeastern Cancer Study Group trial
    • Gockerman JP, Spremulli EN, Raney M, et al. Randomized comparison of Tam versus diethylstilbestrol in estrogen receptorpositive or -unknown metastatic breast cancer: a Southeastern Cancer Study Group trial. Cancer Treat Rep 1986; 7: 1199-3.
    • (1986) Cancer Treat Rep , vol.7 , pp. 1199-1203
    • Gockerman, J.P.1    Spremulli, E.N.2    Raney, M.3
  • 42
    • 0019453438 scopus 로고
    • Tamoxifen versus ethinyl estradiol in the treatment of postmenopausal women with advanced breast cancer
    • Beex L, Pieters G, Smals A, et al. Tamoxifen versus ethinyl estradiol in the treatment of postmenopausal women with advanced breast cancer. Cancer Treat Rep 1981; 65: 179-85.
    • (1981) Cancer Treat Rep , vol.65 , pp. 179-185
    • Beex, L.1    Pieters, G.2    Smals, A.3
  • 43
    • 0033058968 scopus 로고    scopus 로고
    • Randomized trial of diethylstilbestrol vs. Tam in postmenopausal women with metastatic breast cancer. An updated analysis
    • Peethambaram PP, Ingle JN, Suman VJ, et al. Randomized trial of diethylstilbestrol vs. Tam in postmenopausal women with metastatic breast cancer. An updated analysis. Breast Cancer Res Treat 1999; 54: 117-2.
    • (1999) Breast Cancer Res Treat , vol.54 , pp. 117-122
    • Peethambaram, P.P.1    Ingle, J.N.2    Suman, V.J.3
  • 44
    • 0034891355 scopus 로고    scopus 로고
    • High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy
    • Lonning PE, Taylor PD, Anker G, et al. High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy. Breast Cancer Res Treat 2001; 67: 111-16.
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 111-116
    • Lonning, P.E.1    Taylor, P.D.2    Anker, G.3
  • 45
    • 0023726635 scopus 로고
    • Hormone therapy for prostate cancer: Results of the Veterans Administration Cooperative Urological Research Group studies
    • Byar DP, Corle DK. Hormone therapy for prostate cancer: results of the Veterans Administration Cooperative Urological Research Group studies. NCI Monogr 1988; 7: 165-70.
    • (1988) NCI Monogr , vol.7 , pp. 165-170
    • Byar, D.P.1    Corle, D.K.2
  • 46
    • 0000324031 scopus 로고    scopus 로고
    • Diethylstilbestrol is an active agent in prostatic cancer patients after failure to complete androgen blockade
    • Abstract 1372
    • Rosenbaum E, Wygoda M, Gips M, et al. Diethylstilbestrol is an active agent in prostatic cancer patients after failure to complete androgen blockade. Proc Annl Meet Am Soc Clin Oncol. 2000; 349. Abstract 1372.
    • (2000) Proc Annl Meet Am Soc Clin Oncol , pp. 349
    • Rosenbaum, E.1    Wygoda, M.2    Gips, M.3
  • 47
    • 77949879816 scopus 로고    scopus 로고
    • Ellis MJ, Dehdahti F, Kommareddy A, et al. A randomized phase 2 trial of low dose (6 mg daily) versus high dose (30 mg daily) estradiol for patients with estrogen receptor positive aromatase inhibitor resistant advanced breast cancer. SABCS 2008, Abstract 16.
    • Ellis MJ, Dehdahti F, Kommareddy A, et al. A randomized phase 2 trial of low dose (6 mg daily) versus high dose (30 mg daily) estradiol for patients with estrogen receptor positive aromatase inhibitor resistant advanced breast cancer. SABCS 2008, Abstract 16.
  • 48
    • 0026768801 scopus 로고
    • Response after withdrawal of Tamoxifen and progestogens in advanced breast cancer
    • Howell A, Dodwell DJ, Anderson H, et al. Response after withdrawal of Tamoxifen and progestogens in advanced breast cancer. Ann Oncol 1992; 3: 611-7.
    • (1992) Ann Oncol , vol.3 , pp. 611-617
    • Howell, A.1    Dodwell, D.J.2    Anderson, H.3
  • 49
    • 33646352995 scopus 로고    scopus 로고
    • Aromatase inhibitor withdrawal response in metastatic breast cancer
    • Cigler T, Goss PE. Aromatase inhibitor withdrawal response in metastatic breast cancer J Clin Oncol 2006; 24: 1955-6.
    • (2006) J Clin Oncol , vol.24 , pp. 1955-1956
    • Cigler, T.1    Goss, P.E.2
  • 50
    • 1242342972 scopus 로고    scopus 로고
    • Metastatic breast cancer response after Exemestane withdrawal: A case report
    • Bhide SA, Rea DW. Metastatic breast cancer response after Exemestane withdrawal: A case report. Breast 2004; 13: 66-68.
    • (2004) Breast , vol.13 , pp. 66-68
    • Bhide, S.A.1    Rea, D.W.2
  • 52
    • 0036248018 scopus 로고    scopus 로고
    • Aromatization of androgens in women: Current concepts and findings
    • Simpson ER. Aromatization of androgens in women: current concepts and findings. Fertil Steril. 2002; 77: S6-10.
    • (2002) Fertil Steril , vol.77
    • Simpson, E.R.1
  • 53
    • 32544448342 scopus 로고    scopus 로고
    • Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years
    • Honma K,Takubo M, Sawabe M, et al.Estrogen-metabolizing enzymes in breast cancers from women over the age of 80 years. J Clin Endocrinol Metab 2006; 91: 607-13.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 607-613
    • Honma, K.1    Takubo, M.2    Sawabe, M.3
  • 54
    • 0031846672 scopus 로고    scopus 로고
    • Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumors
    • Hall RE, Clements JA, Birrell SN, Tyllei W.Prostate-specific antigen and gross cystic disease fluid protein-15 are co-expressed in androgen receptor-positive breast tumors. Br J Cancer 1998; 78: 360-65.
    • (1998) Br J Cancer , vol.78 , pp. 360-365
    • Hall, R.E.1    Clements, J.A.2    Birrell, S.N.3    Tyllei, W.4
  • 55
    • 0042071592 scopus 로고    scopus 로고
    • Androgen receptors frequently are expressed in breast carcinomas: Potential relevance to new therapeutic strategies
    • Moinfar F, Okeu M, Tsybrovskyy O, et al.: Androgen receptors frequently are expressed in breast carcinomas: Potential relevance to new therapeutic strategies. Cancer 2003; 98: 703-11.
    • (2003) Cancer , vol.98 , pp. 703-711
    • Moinfar, F.1    Okeu, M.2    Tsybrovskyy, O.3
  • 56
    • 0031409463 scopus 로고    scopus 로고
    • Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ
    • Gatalica Z. Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol Res Pract 1997; 193: 753-8.
    • (1997) Pathol Res Pract , vol.193 , pp. 753-758
    • Gatalica, Z.1
  • 59
    • 0037396439 scopus 로고    scopus 로고
    • Endocrine and intracrine sources of androgens in women: Inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone
    • Labrie F, Luu-The V, Labrie C, et al. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocr Rev 2003; 24: 152-82.
    • (2003) Endocr Rev , vol.24 , pp. 152-182
    • Labrie, F.1    Luu-The, V.2    Labrie, C.3
  • 60
    • 0028033594 scopus 로고
    • The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function
    • Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994; 22: 3181-6.
    • (1994) Nucleic Acids Res , vol.22 , pp. 3181-3186
    • Chamberlain, N.L.1    Driver, E.D.2    Miesfeld, R.L.3
  • 61
    • 0037273853 scopus 로고    scopus 로고
    • The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer
    • Lillie EO, Bernstein L, Ursin G. The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer. Breast Cancer Res 2003; 5: 164-73.
    • (2003) Breast Cancer Res , vol.5 , pp. 164-173
    • Lillie, E.O.1    Bernstein, L.2    Ursin, G.3
  • 62
    • 0026068877 scopus 로고
    • Combination hormonal therapy with Tam plus fluoxymesterone versus Tam alone in postmenopausal women with metastatic breast cancer. An updated analysis
    • Ingle JN, Twito DI, Schaid DJ, et al. Combination hormonal therapy with Tam plus fluoxymesterone versus Tam alone in postmenopausal women with metastatic breast cancer. An updated analysis. Cancer 1991; 67: 886.
    • (1991) Cancer , vol.67 , pp. 886
    • Ingle, J.N.1    Twito, D.I.2    Schaid, D.J.3
  • 63
    • 33745926220 scopus 로고    scopus 로고
    • Randomized trial of Tam alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52
    • ngle JN, Suman VJ, Mailliard JA, et al. Randomized trial of Tam alone or combined with fluoxymesterone as adjuvant therapy in postmenopausal women with resected estrogen receptor positive breast cancer. North Central Cancer Treatment Group Trial 89-30-52. Breast Cancer Res Treat. 2006; 98: 217-22.
    • (2006) Breast Cancer Res Treat , vol.98 , pp. 217-222
    • ngle, J.N.1    Suman, V.J.2    Mailliard, J.A.3
  • 64
    • 0034901971 scopus 로고    scopus 로고
    • Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer
    • Geisler J, Detre S, Berntsen H, et al. Influence of neoadjuvant anastrozole (Arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer. Clin Cancer Res. 2001; 7: 1230-6.
    • (2001) Clin Cancer Res , vol.7 , pp. 1230-1236
    • Geisler, J.1    Detre, S.2    Berntsen, H.3
  • 65
    • 0029007560 scopus 로고
    • Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues
    • Recchione C, Venturelli E, Manzari A, et al. Testosterone, dihydrotestosterone and oestradiol levels in postmenopausal breast cancer tissues. J Steroid Biochem Mol Biol 1995; 52 541-6.
    • (1995) J Steroid Biochem Mol Biol , vol.52 , pp. 541-546
    • Recchione, C.1    Venturelli, E.2    Manzari, A.3
  • 66
    • 0035666689 scopus 로고    scopus 로고
    • High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: A renewed role for adrenalectomy
    • Morris K, Toth-Fejel S, Schmidt J, et al. High dehydroepiandrosterone-sulfate predicts breast cancer progression during new aromatase inhibitor therapy and stimulates breast cancer cell growth in tissue culture: A renewed role for adrenalectomy. Surgery 2001; 130: 947-53.
    • (2001) Surgery , vol.130 , pp. 947-953
    • Morris, K.1    Toth-Fejel, S.2    Schmidt, J.3
  • 67
    • 34247892355 scopus 로고    scopus 로고
    • Steroid sulfatase: A new target for the endocrine therapy of breast cancer
    • Stanway SJ, Delavault P, Purohit A, et al. Steroid sulfatase: a new target for the endocrine therapy of breast cancer. The Oncologist 2007; 12: 370-4.
    • (2007) The Oncologist , vol.12 , pp. 370-374
    • Stanway, S.J.1    Delavault, P.2    Purohit, A.3
  • 68
    • 43549093753 scopus 로고    scopus 로고
    • Future clinical prospect in somatostatin/cortistatin/somatostatin receptor field
    • Dalm V, Hofland LJ, Lamberts S. Future clinical prospect in somatostatin/cortistatin/somatostatin receptor field. Mol Cell Endocrinol 2008; 286, 262-77.
    • (2008) Mol Cell Endocrinol , vol.286 , pp. 262-277
    • Dalm, V.1    Hofland, L.J.2    Lamberts, S.3
  • 69
    • 0028670841 scopus 로고
    • Somatostatin analogue octreotide enhances the antineoplastic effects of Tam and ovariectomy on 7,12-dimethylbenz (a)anthracene-induced rat mammary carcinomas
    • Weckbecker G, Tolcsvai L, Stolz B, Pollak M, Bruns C. Somatostatin analogue octreotide enhances the antineoplastic effects of Tam and ovariectomy on 7,12-dimethylbenz (a)anthracene-induced rat mammary carcinomas. Cancer Res 1994; 54: 6334-7.
    • (1994) Cancer Res , vol.54 , pp. 6334-6337
    • Weckbecker, G.1    Tolcsvai, L.2    Stolz, B.3    Pollak, M.4    Bruns, C.5
  • 70
    • 0037080274 scopus 로고    scopus 로고
    • A randomized, multicenter prospective trial assessing longacting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma
    • Bajetta E, Procopio G, Ferrari L, et al. A randomized, multicenter prospective trial assessing longacting release octreotide pamoate plus tamoxifen as a first line therapy for advanced breast carcinoma. Cancer 2002; 94: 299-04.
    • (2002) Cancer , vol.94 , pp. 299-304
    • Bajetta, E.1    Procopio, G.2    Ferrari, L.3
  • 71
    • 0033559620 scopus 로고    scopus 로고
    • A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma
    • Ingle JN, Suman VJ, Kardinal CG, et al. A randomized trial of tamoxifen alone or combined with octreotide in the treatment of women with metastatic breast carcinoma. Cancer 1999; 85: 1284-92
    • (1999) Cancer , vol.85 , pp. 1284-1292
    • Ingle, J.N.1    Suman, V.J.2    Kardinal, C.G.3
  • 73
    • 0021907603 scopus 로고
    • Mechanisms of action of progestational agents
    • Allegra JC, Kiefer SM. Mechanisms of action of progestational agents. Semin Oncol 1985; 12: 3
    • (1985) Semin Oncol , vol.12 , pp. 3
    • Allegra, J.C.1    Kiefer, S.M.2
  • 74
    • 0032530988 scopus 로고    scopus 로고
    • Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: Results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group
    • Buzdar AU, Jonat W, Howell A, et al. Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group. Cancer 1998; 83: 1142-52.
    • (1998) Cancer , vol.83 , pp. 1142-1152
    • Buzdar, A.U.1    Jonat, W.2    Howell, A.3
  • 75
    • 0034128928 scopus 로고    scopus 로고
    • Kaufmann M, Bajetta E, Dirix LY, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. J Clin Oncol2000; 18: 1399-1411.
    • Kaufmann M, Bajetta E, Dirix LY, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a phase III randomized double-blind trial. J Clin Oncol2000; 18: 1399-1411.
  • 76
    • 0035879215 scopus 로고    scopus 로고
    • Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate
    • Buzdar A, Douma N, Davidson N, et al. Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol 2001 19: 3357-66.
    • (2001) J Clin Oncol , vol.19 , pp. 3357-3366
    • Buzdar, A.1    Douma, N.2    Davidson, N.3
  • 77
    • 0031943424 scopus 로고    scopus 로고
    • Dombernowsky P, Smith I, Falkson G, et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol1998; 16: 453-61.
    • Dombernowsky P, Smith I, Falkson G, et al. Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate. J Clin Oncol1998; 16: 453-61.
  • 78
    • 25144511359 scopus 로고    scopus 로고
    • New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: A pooled analysis of the randomized trials
    • Carlini P, Bria E, Giannarelli D, et al. New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials. Cancer 2005; 104: 1335-1342.
    • (2005) Cancer , vol.104 , pp. 1335-1342
    • Carlini, P.1    Bria, E.2    Giannarelli, D.3
  • 79
    • 0027407243 scopus 로고
    • Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia
    • Loprinzi CL, Michalak JC, Schaid DJ, et al. Phase III evaluation of four doses of megestrol acetate as therapy for patients with cancer anorexia and/or cachexia. J Clin Oncol 1993; 11: 762-7.
    • (1993) J Clin Oncol , vol.11 , pp. 762-767
    • Loprinzi, C.L.1    Michalak, J.C.2    Schaid, D.J.3
  • 80
    • 9044244145 scopus 로고    scopus 로고
    • Randomized doubleblind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: A North Central Cancer Treatment Group study
    • Rowland KM, Loprinzi CL, Shaw EG, et al. Randomized doubleblind placebo-controlled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensive-stage small-cell lung cancer: a North Central Cancer Treatment Group study. J Clin Oncol 1996; 14: 135-41.
    • (1996) J Clin Oncol , vol.14 , pp. 135-141
    • Rowland, K.M.1    Loprinzi, C.L.2    Shaw, E.G.3
  • 81
    • 18044372636 scopus 로고    scopus 로고
    • Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer
    • Pascualini J.R. and Chetrite G. Recent insight on the control of enzymes involved in estrogen formation and transformation in human breast cancer. J Steroid Biochem Mol Biol 2005; 93: 221-36.
    • (2005) J Steroid Biochem Mol Biol , vol.93 , pp. 221-236
    • Pascualini, J.R.1    Chetrite, G.2
  • 82
    • 0034016224 scopus 로고    scopus 로고
    • Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues
    • Chetrite GS, Cortes-Prieto J, Philippe JC, et al. Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissues. J Steroid Biochem Molec Biol 2000; 72: 23.
    • (2000) J Steroid Biochem Molec Biol , vol.72 , pp. 23
    • Chetrite, G.S.1    Cortes-Prieto, J.2    Philippe, J.C.3
  • 83
    • 0029872530 scopus 로고    scopus 로고
    • Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer
    • Pasqualini JR, Chetrite G, Blacker C, et al. Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer. J Clin Endocrinol Metab 1996; 81: 1460-4.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1460-1464
    • Pasqualini, J.R.1    Chetrite, G.2    Blacker, C.3
  • 84
    • 0038175996 scopus 로고    scopus 로고
    • High expression of steroid sulfatase mRNA predicts poor prognòsis in patients with estrogen receptor-positive breast cancer
    • Miyoshi Y, Ando A, Hasegawa S, et al. High expression of steroid sulfatase mRNA predicts poor prognòsis in patients with estrogen receptor-positive breast cancer. Clin Cancer Res 2003; 9: 2288-93.
    • (2003) Clin Cancer Res , vol.9 , pp. 2288-2293
    • Miyoshi, Y.1    Ando, A.2    Hasegawa, S.3
  • 85
    • 33645082465 scopus 로고    scopus 로고
    • Phase I study of STX 64 (667 Coumate) in breast cancer patients: The first study of a steroid sulfatase inhibitor
    • Stanway SJ, Purohit A, Woo LW, et al. Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin Cancer Res 2006; 12: 1585-92.
    • (2006) Clin Cancer Res , vol.12 , pp. 1585-1592
    • Stanway, S.J.1    Purohit, A.2    Woo, L.W.3
  • 86
    • 53849119147 scopus 로고    scopus 로고
    • Design and validation of specific inhibitors of 17{beta}-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis
    • Day JM, Tutill HJ, Purohit A, et al. Design and validation of specific inhibitors of 17{beta}-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis. Endocr Relat Cancer 2008; 15: 665-92.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 665-692
    • Day, J.M.1    Tutill, H.J.2    Purohit, A.3


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