Robust transport by multiple motors with nonlinear force-velocity relations and stochastic load sharing

Physical Biology

Volumn 7, Issue 1, 2010, Pages

  Kunwar, Ambarish ^a   Mogilner, Alexander ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MOTOR;

ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; METABOLISM; NONLINEAR SYSTEM; STATISTICS; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; MODELS, BIOLOGICAL; MOLECULAR MOTOR PROTEINS; NONLINEAR DYNAMICS; STOCHASTIC PROCESSES;

EID: 77949858821     PISSN: 14783967     EISSN: 14783975     Source Type: Journal    
DOI: 10.1088/1478-3975/7/1/016012     Document Type: Article

References (44)

1. Vale R D 2003 The molecular motor toolbox for intracellular transport Cell 112 467-70
2. Rogers S L and Gelfand V I 2000 Membrane trafficking, organelle transport, and the cytoskeleton Curr. Opin. Cell Biol. 12 57-62
3. Welte M A, Gross S P, Postner M, Block S M and Wieschaus E F 1998 Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics Cell 92 547
4. Walczak C E and Heald R 2008 Mechanisms of mitotic spindle assembly and function Int. Rev. Cytol. 265 111-8
5. Glotzer M 2005 The molecular requirements for cytokinesis Science 307 1735-9
6. Schliwa M and Woehlke G 2003 Molecular motors Nature 422 759-65
7. Moffitt J R, Chemla Y R, Smith S B and Bustamante C 2008 Recent advances in optical tweezers Annu. Rev. Biochem. 77 205-8
8. Kolomeisky A B and Fisher M E 2007 Molecular motors: a theorist's perspective Annu. Rev. Phys. Chem. 58 675
9. Vershinin M, Carter B C, Razafsky D S, King S J and Gross S P 2007 Multiple-motor based transport and its regulation by Tau Proc. Natl Acad. Sci. USA 104 87-92
10. Schnitzer M J, Visscher K and Block S M 2000 Force production by single kinesin motors Nat. Cell Biol. 2 718-23
11. Coppin C M, Pierce D W, Hsu L and Vale R D 1997 The load dependence of kinesin's mechanical cycle Proc. Natl Acad. Sci. USA 94 8539-44
12. Gross S P, Vershinin M and Shubeita G T 2007 Cargo transport: two motors are sometimes better than one Curr. Biol. 17 R478-86
13. Mallik R, Petrov D, Lex S A, King S J and Gross S P 2005 Building complexity: an in vitro study of cytoplasmic dynein with in vivo implications Curr. Biol. 15 2075
14. Badoual M, Julicher F and Prost J 2002 Bidirectional cooperative motion of molecular motors Proc. Natl Acad. Sci. USA 99 6696-701
15. Duke T 2000 Cooperativity of myosin molecules through strain-dependent chemistry Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 529-38
16. Shu Y and Shi H 2004 Cooperative effects on the kinetics of ATP hydrolysis in collective molecular motors Phys. Rev. E 69 (2 Pt 1) 021912
17. Leibler S and Huse D A 1993 Porters versus rowers: a unified stochastic model of motor proteins J. Cell Biol. 121 1357-8
18. Julicher F and Prost J 1995 Cooperative molecular motors Phys. Rev. Lett. 75 2618-21
19. Vermeulen K C, Stienen G J M and Schmid C F 2002 Cooperative behavior of molecular motors J. Muscle Res. Cell Motil. 23 71-9
20. Vilfan A, Frey E and Schwabl F 1998 Elastically coupled molecular motors Eur. Phys. J. B 3 535-46
21. Julicher F, Ajdari A and Prost J 1997 Modeling molecular motors Rev. Mod. Phys. 69 1269-81
22. Campas O, Kafri Y, Zeldovich K B, Casademunt J and Joanny J-F 2006 Collective dynamics of interacting molecular motors Phys. Rev. Lett. 97 038101
23. Campas O, Leduc C, Bassereau P, Casademunt J, Joanny J-F and Prost J 2008 Coordination of Kinesin motors pulling on fluid membranes Biophys. J. 94 5009-17
24. Klumpp S and Lipowsky R 2005 Cooperative cargo transport by several molecular motors Proc. Natl Acad. Sci. USA 102 17284-9
25. Nedelec F 2002 Computer simulations reveal motor properties generating stable antiparallel microtubule interactions J. Cell Biol. 158 1005
26. Wollman R, Civelekoglu-Scholey G, Scholey J M and Mogilner A 2008 Reverse engineering of force integration during mitosis in the Drosophila embryo Mol. Syst. Biol. 4 195
27. Valentine M T, Fordyce P M, Krzysiak T C, Gilbert S P and Block S M 2006 Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro Nat. Cell Biol. 8 470-6
28. Gebhardt J C M, Clemen A E-M, Jaud J and Rief M 2006 Myosin-V is a mechanical ratchet Proc. Natl Acad. Sci. USA 103 8680-5
29. Janson M E and Dogterom M 2004 Scaling of microtubule force-velocity curves obtained at different tubulin concentrations Phys. Rev. Lett. 92 248101
30. Singh M P, Mallik R, Gross S P and Yu C C 2005 Monte Carlo modeling of single-molecule cytoplasmic dynein Proc. Natl Acad. Sci. USA 102 12059-64
31. Toba S, Watanabe T M, Yamaguchi-Okimoto L, Toyoshima Y Y and Higuchi H 2006 Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein Proc. Natl Acad. Sci. USA 103 5741-5
32. Kunwar A, Vershinin M, Xu J and Gross S P 2008 Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport Curr. Biol. 18 1173
33. Keren K, Pincus Z, Allen G M, Barnhart E L, Marriott G, Mogilner A and Theriot J A 2008 Mechanism of shape determination in motile cells Nature 453 475-80
34. Grill S W, Kruse K and Julicher F 2005 Theory of mitotic spindle oscillations Phys. Rev. Lett. 94 108104
35. Beeg J, Klumpp S, Dimova R, Gracia R S, Unger E and Lipowsky R 2008 Transport of beads by several kinesin motors Biophys. J. 94 532-41
36. Jeney S, Stelzer E H K, Grubmüller H and Florin E-L 2004 Mechanical properties of single motor molecules studied by three-dimensional thermal force probing in optical tweezers Chemphyschem 5 1150-8
37. Kural C, Kim H, Syed S, Goshima G, Gelfand V I and Selvin P R 2005 Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Science 308 1469-72
38. Mogilner A, Elston T, Wang H-Y and Oster G 2002 Molecular motors: theory Joel Keizer's Computational Cell Biology ed C P Fall, E Marland, J Tyson and J Wagner (New York: Springer) pp 321-55
39. Schnitzer M J and Block S M 1995 Statistical kinetics of processive enzymes Cold Spring Harb. Symp. Quant. Biol. 60 793-802
40. Müller M J I, Klumpp S and Lipowsky R 2008 Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors Proc. Natl Acad. Sci. USA 105 4609-14
41. Tao L,Mogilner A, Civelekoglu-Scholey G,Wollman R, Evans J, Stahlberg H and Scholey J M 2006 A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays Curr. Biol. 16 2293-302
42. Shtridelman Y, Cahyuti T, Townsend B, DeWitt D and Macosko J C 2008 Force-velocity curves of motor proteins cooperating in vivo Cell Biochem. Biophys. 52 19-29
43. Rogers A R, Driver J W, Constantinou P E, Kenneth Jamison D and Diehl M R 2009 Negative interference dominates collective transport of kinesin motors in the absence of load Phys. Chem. Chem. Phys. 11 4882-9
44. Shubeita G T, Tran S L, Xu J, Vershinin M, Cermelli S, Cotton S L,Welte M A and Gross S P 2008 Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets Cell 135 1098-107