Granule size distribution of tablets

Journal of Pharmaceutical Sciences

Volumn 99, Issue 4, 2010, Pages 2061-2069

  Virtanen, Satu ^a   Antikainen, Osmo ^a   Räikkönen, Heikki ^a   Yliruusi, Jouko ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Compaction; Compression; Mechanical properties; Particle size; Physical characterization; Powder technology; Solid state; Tableting

Indexed keywords

ALPHA LACTOSE; MICROCRYSTALLINE CELLULOSE; POVIDONE; THEOPHYLLINE;

AQUEOUS SOLUTION; ARTICLE; DRUG GRANULATION; DRUG GRANULE; FILTRATION; PARTICLE SIZE; POWDER; SEGREGATION ANALYSIS; TABLET FORMULATION; TABLET MACHINE;

EID: 77949851019     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21945     Document Type: Article

References (32)

1. Hersey JA, Bayraktar G, Shotton E. 1967. The effect of particle size on the strength of sodium chloride tablets. J Pharm Pharmacol 19:24S-30S.
2. Fan A, Parlerla S, Carlson G, Ladipo D, Dukich J, Capella R, Leung S. 2005. Effect of particle size distribution and flow property of powder blend on tablet weight variation. Am Pharm Rev 8:73-78.
3. Deanne R, Etzler FM. Particle size analysis and powder sampling. Am Pharm Rev [cited 2009 June 3] Available from: http://www.american- pharmaceuticalreview. com/ViewArticle.aspx?Content ID=456.
4. Sun CC, Himmelspach MW. 2006. Reduced tablet-ability of roller compacted granules as a result of granule size enlargement. J Pharm Sci 95:200-206.
5. Yalkowsky SH, Bolton S. 1990. Particle size and content uniformity. Pharm Res 7:962-966.
6. Rohrs BR, Amidon GE, Meury RH, Secreast PJ, King HM, Skoug CJ. 2006. Particle size limits to meet USP content uniformity criteria for tablets and capsules. J Pharm Sci 95:1049-1059.
7. Heng PWS, Chan LW, Easterbrook MG, Li X. 2001. Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets. J Controlled Release 76:39-49.
8. Carless JE, Sheak S. 1975. Changes in the particle size distribution during tableting of sulphathiazole powder. J Pharm Pharmacol 28:17-22.
9. Jillavenkatesa A, Kelly J, Dapkunas SJ. 2002. Some issues in particle size and size distribution characterization of powders. Am Pharm Rev 5:98-105.
10. Marks AM, Sciarra JJ. 1968. Effect of size on other physical properties of granules and their corresponding tablets. J Pharm Sci 57:497-504.
11. Harnby N. 2000. An engineering view of pharmaceutical powder mixing. Pharm Sci Technol Today 3:303-309.
12. Patel S, Kaushal AD, Bansal AK. 2006. Compression physics in the formulation development of tablets. Crit Rev Ther Drug Carrier Syst 23:1-65.
13. Nyström C, Alderborn G, Duberg M. 1993. Bonding surface area and bonding mechanism - two important factors for the understanding of powder compactability. Drug Dev Ind Pharm 19:2143-2196.
14. Yajima T, Itai S, Hayashi H, Takayama K, Nagai T. 1996. Optimization of size distribution of granules for tablet compression. Chem Pharm Bull 44:1056-1060.
15. Sun C, Grant DJW. 2001. Effects of initial particle size on the tableting properties of L-lysine monohydrochloride dehydrate powder. Int J Pharm 215:221-228.
16. Fichtner F, Rasmuson A, Alderborn G. 2005. Particle size distribution and evolution in tablet structure during and after compaction. Int J Pharm 292:211-225.
17. Lee T, Kuo CS. 2006. Effects of initial average particle size on tableting: Evaluating predictive tools for crystal engineers and formulators. Pharm Tech.
18. Adolfsson A°, Gustafsson C, NyströmC. 1999. Use of tablet tensile strength adjusted for surface area and mean interparticulate distance to evaluate dominating bonding mechanisms. Drug Dev Ind Pharm 26:753-764.
19. Ridgway K, Williams IE. 1977. The effect of particle shape and size distribution on granulation bulk density and tablet weight variation. J Pharm Pharmacol 29:57P.
20. Carson JW. 1988. Overcoming particle segregation in the pharmaceutical and cosmetic industries. Drug Dev Ind Pharm 14:2749-2758.
21. Prescott JK, Hossfeld RJ. 1994. Maintaining product uniformity and uninterrupted flow to direct compression tablet presses. Pharm Tech 18:99-114.
22. Antikainen O, Tervakangas H, Pietiläinen J, Yliruusi J, Sandler N. 2006. Screening of particle size related segregation behavior of granules with surface image analysis. AAPS J 8.
23. Xie L, Wu H, Shen M, Augsburger LL, Lyon RC, Khan MA, Hussain AS, Hoag SW. 2008. Quality-by-Design (QbD): Effects of testing parameters and formulation variables on the segregation tendency of pharmaceutical powders measured by the ASTM D 6940-04 segregation tester. J Pharm Sci 97:4485-4497.
24. Spring MS. 1977. The segregation of granules during tableting. J Pharm Pharmacol Commun 29: 513-514.
25. Khan KA, Rhodes CT. 1975. Effect of compaction on particle size. J Pharm Sci 64:444-447.
26. Antikainen O. 2003. New methods to evaluate applicability of powders and granules for tablet compression. Ph.D. Thesis. Yliopistopaino, Helsinki, Finland.
27. Zhuikova NN, Sablina OS, Gavrilov AS. 2009. Effects of moisture on the pressing of pharmaceutical powders. Pharm Chem J 43:62-64.
28. Närvänen T, Lipsanen T, Antikainen O, Räikkönen H, Yliruusi J. 2008. Controlling granule size of granulation liquid feed pulsing. Int J Pharm 357: 132-138.
29. Petrak D. 2002. Simultaneous measurement of particle size and particle velocity by the spatial filtering technique. Part Part Syst Charact 19:391-400.
30. Laitinen N, Antikainen O, Rantanen J, Yliruusi J. 2004. New perspectives for visual characterization of pharmaceutical solids. Int J Pharm 93:165-176.
31. Krogars K, Antikainen O, Heinämäki J, Laitinen N, Yliruusi J. 2002. Tablet film-coating with amyloserich maize starch. Eur J Pharm Sci 17:23-30.
32. Marshal K. 1986. Compression and consolidation of powdered solids. In: Lachman L, Lieberman HA, Kanig JL, editors. Theory and practice of industrial pharmacy. 3rd edition. Philadelphia: Lea & Fabiger. pp. 66-99.