Optimization of size distribution of granules for tablet compression

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 5, 1996, Pages 1056-1060

  Yajima, Toshio ^a   Itai, Shigeru ^a   Hayashi, Hidefumi ^a   Takayama, Kozo ^b   Nagai, Tsuneji ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b HOSHI UNIVERSITY   (Japan)

Author keywords

high shear mixer; logarithmic normal distribution; optimum granule size distribution; tablet granulation; tablet hardness; weight variation

Indexed keywords

CELLULOSE; HYDROXYPROPYLCELLULOSE; MANNITOL; STARCH;

ARTICLE; DRUG GRANULATION; DRUG MANUFACTURE; HARDNESS; PARTICLE SIZE; PHARMACEUTICS; PHYSICAL CHEMISTRY; PREDICTION; SHEAR RATE; SURFACE PROPERTY; TABLET;

EID: 0029978578     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1056     Document Type: Article

References (12)

1. A part of this work was presented at the 6th International Symposium on Agglomeration of Japan, Nagoya, 1993.
2. Vojnovic D., Moneghini M., Rubessa F., Drug Dev. Ind. Pharm., 20, 1035-1047 (1994).
3. Nyqvist H., Acta Pharm, Suec., 19, 413-420 (1982).
4. El-Gindy N. A., Samaha M. W., El-Maradny H. A., Drug Dev. Ind. Pharm., 14, 977-1005 (1988).
5. Asao M., Kusunoki T., Ando T., Nakanura T., "Jikken Keikakuho," Nikkagiren, Tokyo, 1973, pp. 313-346.
6. Takayama K., The Proceedings of the Hoshi University, 26, 11-18 (1984).
7. Takai T., Takayama K., Nambu N., Nagai T., Chem. Pharm. Bull., 32, 1942-1947 (1984).
8. Itai S., Funtai Kougaku Kaishi, 24, 89-100 (1987).
9. Itai S., Nagai T., Chem. Pharm. Bull., 33, 1641-1651 (1985).
10. Carr, Chemical Engineering, Jan. 18, 166-167 (1965).
11. Takayama K., Nambu N., Nagai T., Chem. Pharm. Bull., 31, 4496-4507 (1983).
12. Takayama K., Nagai T., Chem. Pharm. Bull., 37, 160-167 (1989).