Anti-nucleosome antibodies as a disease marker in systemic lupus erythematosus and its correlation with disease activity and other autoantibodies

Indian Journal of Dermatology, Venereology and Leprology

Volumn 76, Issue 2, 2010, Pages 145-149

  Pradhan, Vandana D ^a   Patwardhan, Manisha M ^a   Ghosh, Kanjaksha ^a  

^a KEM HOSPITAL   (India)

Author keywords

Anti double stranded DNA antibodies; Anti histone antibodies; Anti nucleosome antibodies; Lupus nephritis; SLE without nephritis; Systemic lupus erythematosus

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; DNA ANTIBODY; HISTONE ANTIBODY; NUCLEOSOME ANTIBODY; NUCLEOSOME AUTOANTIBODY; BIOLOGICAL MARKER; NUCLEOSOME;

ADULT; ANTIBODY DETECTION; ARTICLE; CROSS-SECTIONAL STUDY; DISEASE ACTIVITY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; KIDNEY BIOPSY; KIDNEY DISEASE; LABORATORY DIAGNOSIS; LABORATORY TEST; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; SYSTEMIC LUPUS ERYTHEMATOSUS; ADOLESCENT; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; IMMUNOLOGY; LUPUS ERYTHEMATOSUS, SYSTEMIC; METABOLISM; NUCLEOSOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CROSS-SECTIONAL STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; NUCLEOSOMES; YOUNG ADULT;

EID: 77949809453     PISSN: 03786323     EISSN: 09733922     Source Type: Journal    
DOI: 10.4103/0378-6323.60558     Document Type: Article

References (20)

1. Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y. Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum 2004;34:501-537
2. Gosink J. Anti-nucleosome antibodies: specific markers for SLE. Autoimmunity. As published in CLI, Nov 2005.
3. Urowitz MB. Association of anti-nucleosome antibodies with disease flare in serologically active clinically quiescent patients with SLE. Future Rheumatology 2007;2:139-141
4. Amoura Z, Koutouzov S, Chabre H, Cacoub P, Amoura I, Musset L, et al. Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases: antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus. Arthritis Rheum 2000;43:76-84.
5. Amoura Z, Koutouzov S, Piette JC. The role of nucleosomes in lupus. Curr Opin Rheumatol 2000;12:369-373
6. Berden JH. Lupus Nephritis. Kidney Int 1997;52:538-558
7. Berden JH, Grootscholten C, Jürgen WC, van der Vlag J. Lupus nephritis: a nucleosome waste disposal defect ? J Nephrol 2002;15:S1-10.
8. Gutiérrez-Adrianzén OA, Koutouzov S, Mota RM, das Chagas Medeiros MM, Bach JF, de Holanda Campos H. Diagnostic value of anti-nucleosome antibodies in the assessment of disease activity of systemic lupus erythematosus: a prospective study comparing anti-nucleosome with anti-dsDNA antibodies. J Rheumatol 2006;3:1538-1544
9. Bigler C, Lopez-Trascasa M, Potlukova E, Moll S, Danner D, Schaller M, et al. Antinucleosome antibodies as a marker of active proliferative lupus nephritis. Am J Kidney Dis 2008;51:624-629
10. Haddouk S, Ben Ayed M, Baklouti S, Hachicha J, Bahloul Z, Masmoudi H. Clinical significance of anti-nucleosome antibodies in Tunisian systemic lupus erythematosus patients. Clin Rheumatol 2005;24:219-222
11. Simón JA, Cabiedes J, Ortiz E, Alcocer-Varela J, Sánchez- Guerrero J. Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker. Rheumatology (Oxford) 2004;43:220-224
12. Krippner H, Springer B, Merle S, Pirlet K. Antibodies to histones of the IgG and IgM class in systemic lupus erythematosus. Clin Exp Immunol 1984;58:49-56.
13. Pradhan V, Badakere S, Ghosh K. Anti-histone and other autoantibodies in thalassemia major patients receiving iron chelators. Acta Hematol 2003;109:35-39
14. Min DJ, Kim SJ, Park SH, Seo YI, Kang HJ, Kim WU, et al, Antinucleosome antibody: significance in lupus patients lacking anti-double stranded DNA antibody. Clin Exp Rheumatol 2002;20:13-18
15. Bigler C, Lopez-Trascasa M, Potlukova E, Moll S, Danner D, Schaller M, et al, Antinucleosome antibodies as a marker of active proliferative lupus nephritis. Am J Kidney Dis 2008;51:624-629
16. Düzgün N, Sahin M, Genç Y, Tutkak H. Anti-nucleosome Antibodies and Systemic lupus Erythematosus. Ann N Y Acad Sci 2007;1109:421-428
17. Gómez-Puerta JA, Burlingame RW, Cervera R. Anti-Chromatin (Anti-Nucleosome) Antibodies. Lupus 2006;15:408-411
18. Su Y, Jia RL, Han L, Li ZG. Role of anti-nucleosome antibody in the diagnosis of systemic lupus erythematosus. Clin Immunol 2007;122:115-120
19. Quattrocchi P, Barrile A, Bonanno D, Giannetto L, Patafi M, Tigano V, et al. The role of anti-nucleosome antibodies in systemic lupus erythematosus. Results of a study of patients with systemic lupus erythematosus. Rheumatismo 2005;57:109-113
20. Gómez-Puerta JA, Burlingame RW, Cervera R. Anti-chromatin (anti-nucleosome) antibodies: Diagnostic and clinical value. Autoimmun Rev 2008;7:606-611