Clinical significance of antinucleosome antibodies in Tunisian systemic lupus erythematosus patients

Clinical Rheumatology

Volumn 24, Issue 3, 2005, Pages 219-222

  Haddouk, S ^a   Ayed, M Ben ^a   Baklouti, S ^b   Hachicha, J ^b   Bahloul, Z ^b   Masmoudi, Hatem ^a  

^a HABIB BOURGUIBA HOSPITAL   (Tunisia)

^b HEDI CHAKER HOSPITAL   (Tunisia)

Author keywords

Antinuclear antibodies; Antinucleosome antibodies; Systemic lupus erythematosus

Indexed keywords

DNA ANTIBODY; DOUBLE STRANDED DNA; IMMUNOGLOBULIN G ANTIBODY; NUCLEOSOME ANTIBODY;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTHRALGIA; ARTHRITIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; NEPHRITIS; PRIORITY JOURNAL; SCHOOL CHILD; SCORING SYSTEM; SYSTEMIC LUPUS ERYTHEMATOSUS; TUNISIA;

ADOLESCENT; ADULT; AGED; ANTIBODIES, ANTINUCLEAR; CHILD; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FOLLOW-UP STUDIES; HUMANS; IMMUNOBLOTTING; INCIDENCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NUCLEOSOMES; RETROSPECTIVE STUDIES; TUNISIA; URBAN POPULATION;

EID: 20944431695     PISSN: 07703198     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10067-004-1005-5     Document Type: Article

References (20)

1. Tan EM (1989) Antinuclear antibodies: Diagnostic markers for autoimmune diseases and probes for cell biology. Adv Immunol 44:93-151 1:CAS:528:DyaL1MXhslWhtbk%3D
2. Mohan C, Adams S, Stanik V, Datta SK (1993) Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus. J Exp Med 177:1367-1381 10.1084/jem.177.5.1367
3. Luger K, Mader AW, Richmond RK, Sargent DF, Richmond TJ (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389:251-260 10.1038/38444
4. Amoura Z, Chabre H, Koutouzov S, Lotton C, Cabrespines A, Bach JF, Jacob L (1994) Nucleosome-restricted antibodies are detected before anti-dsDNA and/or antihistone antibodies in serum of MRL-Mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria. Arthritis Rheum 37:1684-1688 1:CAS:528:DyaK2MXitlGqtbk%3D
5. Kramers C, Hylkema MN, Van Bruggen MC, Van de Lagemaat R, Dijkman HB, Assmann KJ et al (1994) Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest 94:568-577 1:CAS:528:DyaK2cXlsFGms7g%3D
6. Burlingame RW, Boey ML, Starkebaum G, Rubin RL (1994) The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus. J Clin Invest 94:184-192 1:CAS:528:DyaK2cXltlais7o%3D
7. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725 1:STN:280:ByiH28vitFU%3D
8. Vitali C, Bencivelli W, Isenberg DA, Smolen JS, Snaith ML, Sciuto M et al (1992) Disease activity in systemic lupus erythematosus: Report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of variables indicative of disease activity and their use in the development of an activity score. The European Consensus Study Group for Disease Activity in SLE. Clin Exp Rheumatol 10:541-547 1:STN:280:ByyD1M3ksFQ%3D
9. Churg J, Bernstein J, Glassock RJ (1995) Lupus nephritis. In: Renal disease: Classification and atlas of glomerular diseases, 2nd edn. Igaku-Shoin Medical Publishers, New York, pp 51-79
10. Emlen W, Holers VM, Arend WP, Kotzin B (1992) Regulation of nuclear antigen expression on the cell surface of human monocytes. J Immunol 148:3042-3048 1:CAS:528:DyaK38Xkt1CnsLs%3D
11. Andreassen K, Bredholt G, Moens U, Bendiksen S, Kauric G, Rekvig OP (1999) T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: A molecular basis for anti-DNA antibody production. Eur J Immunol 29:2715-2728 10.1002/ (SICI)1521-4141(199909)29:09<2715::AID-IMMU2715>3.3.CO;2-R
12. Amoura Z, Koutouzov S, Chabre H, Cacoub P, Amoura I, Musset L et al (2000) Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases. Antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus. Arthritis Rheum 43:76-84 10.1002/ 1529-0131(200001)43:1<76::AID-ANR10>3.0.CO;2-I
13. Bruns A, Blass S, Hausdorf G, Burmester GR, Hiepe F (2000) Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus. Arthritis Rheum 43:2307-2315 10.1002/ 1529-0131(200010)43:10<2307::AID-ANR19>3.0.CO;2-J
14. Cairns AP, McMillan SA, Crockard AD, Meenagh GK, Duffy EM, Armstrong DJ, Bell AL (2003) Antinucleosome antibodies in the diagnosis of systemic lupus erythematosus. Ann Rheum Dis 62:272-273 10.1136/ard.62.3.272
15. Min DJ, Kim SJ, Park SH, Seo YI, Kang HJ, Kim WU et al (2002) Anti-nucleosome antibody: Significance in lupus patients lacking anti-double-stranded DNA antibody. Clin Exp Rheumatol 20:13-18 1:STN:280:DC%2BD387mtFSrsw%3D%3D
16. Benucci M, Gobbi FL, Del Rosso A, Cesaretti S, Niccoli L, Cantini F (2003) Disease activity and antinucleosome antibodies in systemic lupus erythematosus. Scand J Rheumatol 32:42-45 10.1080/03009740310000391
17. Burlingame RW, Rubin RL, Balderas RS, Theofilopoulos AN (1993) Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. J Clin Invest 91:1687-1696 1:CAS:528:DyaK3sXisFeitL4%3D
18. Abraham-Simon J, Rojas-Serrano J, Cabiedes J, Alcocer-Varela J (2004) Antinucleosome antibodies may help predict development of systemic lupus erythematosus in patients with primary antiphospholipid syndrome. Lupus 13:177-181 1:STN:280:DC%2BD2c3itFWksQ%3D%3D
19. Suenaga R, Abdou NI (1996) Anti-(DNA-histone) antibodies in active lupus nephritis. J Rheumatol 23:279-284 1:STN:280:ByiD3snjvVA%3D
20. Van Bruggen MC, Kramers C, Hylkema MN, Smeenk RJ, Berden JH (1996) Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice. Clin Exp Immunol 105:132-139 10.1046/j.1365-2249.1996.d01-731.x