60 kD Ro and nRNP A frequently initiate human lupus autoimmunity

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Heinlen, Latisha D ^a,b   McClain, Micah T ^a   Ritterhouse, Lauren L ^a,b   Bruner, Benjamin F ^a   Edgerton, Colin C ^c   Keith, Michael P ^c   James, Judith A ^a,b   Harley, John B ^a,b,d  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c WALTER REED ARMY MEDICAL CENTER   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

60 KD RO; AUTOANTIGEN; PHOSPHOLIPID ANTIBODY; PROTEIN; RHEUMATOID FACTOR; UNCLASSIFIED DRUG; EPITOPE; RIBONUCLEOPROTEIN; SS A ANTIGEN; SS-A ANTIGEN;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; SERUM; SYSTEMIC LUPUS ERYTHEMATOSUS; BLOOD; CASE CONTROL STUDY; CHEMISTRY; HELA CELL; IMMUNOLOGY;

AUTOANTIGENS; AUTOIMMUNITY; CASE-CONTROL STUDIES; EPITOPES; FEMALE; HELA CELLS; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; RIBONUCLEOPROTEINS;

EID: 77949702395     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009599     Document Type: Article

References (39)

1. Maddison PJ, Reichlin M (1997) Quantitation of precipitating antibodies to certain soluble nuclear antigens in systemic lupus erythematosus. Their contribution to hypergamma-globulinemia. Arthritis Rheum 20: 819-825.
2. Hahn BH (1998) Antibodies to DNA. NEJM 338: 1359-68.
3. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, et al. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25: 1271-7.
4. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725.
5. Reichlin M, Wolfson-Reichlin M (2003) Correlations of anti-dsDNA and antiribosomal P autoantibodies with lupus nephritis. Clin Immunol 108: 69-72.
6. Krishnan C, Kaplan MH (1967) Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J Clin Invest 46: 569-79.
7. Yung S, Chan TM (2008) Anti-DNA antibodies in the pathogenesis of lupus nephritis - The emerging mechanisms. Autoimmunity Rev 7: 317-321.
8. Tseng CE, Buyon JP, Kim M, Belmont HM, Mackay M, et al. (2006) The effect of moderate-dose corticosteroids in preventing severe flares in patients with serologically active, but clinically stable, systemic lupus erythematosus: findings of a prospective, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 54: 3623-32.
9. Gómez-Puerta JA, Burlingame RW, Cervera R (2008) Anti-chromatin (antinucleosome) antibodies: diagnostic and clinical value. Autoimmun Rev 7: 606-11.
10. Field M, Williams DG, Charles P, Maini RN (1988) Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: increased sensitivity of detection using purified peptide antigens. Ann Rheum Dis 47: 820-825.
11. Arnett FC, Hamilton RG, Roebber MG, Harley JB, Reichlin M (1988) Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus. J Rheumatol 15: 1773-1776.
12. Clotet B, Guardia J, Pigrau C, Lience E, Murcia C, et al. (1984) Incidence and clinical significance of anti-ENA antibodies in systemic lupus erythematosus. Estimation by counterimmunoelectrophoresis. Scand J Rheumatol 13: 15-20.
13. Scofield RH, Zhang FC, Kurien BT, Harley JB (1997) Anti-Ro fine specificity defined by multiple antigenic peptides identifies components of tertiary epitopes. Clin Exp Immunol 109: 480-7.
14. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, et al. (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349: 1526-33.
15. Greidinger EL, Hoffman RW (2001) The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1-70 kd and B'/B proteins as predominant U1 RNP immunogens. Arthritis Rheum 44: 368-75.
16. James JA, Harley JB (1998) B-cell epitope spreading in autoimmunity. Immunol Rev 164: 185-200.
17. Arbuckle MR, Reichlin M, Harley JB, James JA (1999) Shared early autoantibody recognition events in the development of anti-Sm B/B' in human lupus. Scand J Immunol 50: 447-55.
18. James JA, Gross T, Scofield RH, Harley JB (1995) Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/ B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. J Exp Med 181: 453-61.
19. Fisher DE, Reeves WH, Wisniewolski R, Lahita RG, Chiorazzi N (1985) Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus. Arthritis Rheum 28: 1348-55.
20. McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, et al. (2005) Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 11: 85-9.
21. McCluskey J, Farris AD, Keech CL, Purcell AW, Rischmueller M, et al. (1998) Determinant spreading: lessons from animal models and human disease. Immunol Rev 164: 209-29.
22. Scofield RH, Kaufman KM, Baber U, James JA, Harley JB, et al. (1999) Immunization of mice with human 60-kd Ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse. Arthritis Rheum 42: 1017-24.
23. Arbuckle MR, James JA, Kohlhase KF, Rubertone MV, Dennis GJ, et al. (2001) Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scand J Immunol 54: 211-9.
24. Arbuckle MR, James JA, Dennis GJ, Rubertone MV, McClain MT, et al. (2003) Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus. Lupus 12: 99-106.
25. Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, et al. (2007) Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum 56: 2344-51.
26. McClain MT, Arbuckle MR, Heinlen LD, Dennis GJ, Roebuck J, et al. (2004) The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 50: 1226-32.
27. James JA, Harley JB (1992) Linear epitope mapping of an Sm B/B' polypeptide. J Immunol 148: 2074-9.
28. Poole BD, Schneider RI, Guthridge JM, Velte C, Reichlin M, et al. (2009) Early targets of nRNP humoral autoimmunity in human SLE. Arthritis Rheum In press.
29. James JA, Harley JB (1995) Peptide autoantigenicity of the small nuclear ribonucleoprotein C. Clin Exp Rheumatol 13: 299-305.
30. James JA, Harley JB (1996) Human anti-nRNP A Abs recognize contiguous surface structures of the RNA binding domain and segregate into two sequential epitope binding patterns. J Immunol 156: 4018-4026.
31. James JA, Scofield RH, Harley JB (1997) Lupus humoral autoimmunity after short peptide immunization. Ann N Y Acad Sci 815: 124-7.
32. Poole BD, Gross T, Maier S, Harley JB, James JA (2008) Autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmunity 31: 362-71.
33. Sundar K, Jacques S, Gottlieb P, Villars R, Benito ME, et al. (2004) Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. J Autoimmunity Sep; 23(2): 127-40.
34. Marchini B, Dolcher MP, Sabbatini A, Klein G, Migliorini P (1994) Immune response to different sequences of the EBNA I molecule in Epstein-Barr virus-related disorders and in autoimmune diseases. J Autoimmun 7: 179-91.
35. Binder SR, Genovese MC, Merrill JT, Morris RI, Metzger AL (2005) Computer-assisted pattern recognition of autoantibody results. Clin Diagn Lab Immunol 12: 1353-7.
36. Moder KG, Wener MH, Weisman MH, Ishimori ML, Wallace DJ, et al. (2007) Measurement of Antinuclear Antibodies by Multiplex Immunoassay: A Prospective, Multi-center Clinical Evaluation. J Rheum 34: 978-86.
37. Binder SR (2006) Autoantibody detection using multiplex technologies. Lupus 15: 412-21.
38. Shovman O, Gilburd B, Barzilai O, Shinar E, Lirida B, et al. (2005) Evaluation of the BioPlex 2200 ANA screen: analysis of 510 healthy subjects: incidence of natural/predictive autoantibodies. Ann NY Acad Sci 1050: 380-8.
39. McClain MT, Ramsland PA, Kaufman KM, James JA (2002) Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. J Immunol 168: 2054-62.