Human lupus anti-spliceosome a protein autoantibodies bind contiguous surface structures and segregate into two sequential epitope binding patterns

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 4018-4026

  James, Judith A ^b   Harley, John B ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; EPITOPE; NUCLEAR RNA; RIBONUCLEOPROTEIN ANTIBODY;

ANTIBODY COMBINING SITE; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SPLICEOSOME; STRUCTURE ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ANTIGENS, SURFACE; AUTOANTIBODIES; BINDING SITES, ANTIBODY; CROSS REACTIONS; EPITOPE MAPPING; EPITOPES; FEMALE; HUMANS; IMMUNE SERA; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; RIBONUCLEOPROTEINS; SPLICEOSOMES;

EID: 0030005013     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Theissen, H., M. Etqerodt, R Reuter, C. Schneider, F. Lottspeich, P. Argos, R. Luhrmann, and L Philipson. 1986 Cloning of the human cDNA for the U1 RNA-associated 70K protein EMBO J. 5:3209.
2. Query, C. C., R. C. Bentley, and J. D. Keene. 1989. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell 57.89.
3. Spritz, R. A , K. Strunk, C. S. Surowy, S O. Hoch, D. E. Barton, and U. Franke. 1987 The human U1-70K snRNP protein cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding. Nucleic Acid Res. 15: 10373
4. Sillekens, P T. G., W. J. Habets, R. P. Beijer, and W. J. Venrooij. 1987. cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J. 6:1841.
5. Sillekens, P. T. G., R P. Beijer, W. J. Habets, and W. J. van Venrooij. 1988. Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. Nucleic Acids Res. 16:8307.
6. Lutz-Freyermuth, C., C C. Query, and J. D. Keene. 1990. Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. Proc. Natl. Acad. Sci USA 87:6393.
7. Scherly, D., W Boelens, W. J van Venrooij, N. A. Dathan, J. Hamm, and I. W. Mattaj. 1990 Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J. 8:4163.
8. Elkon, K. B., J. J. Hines, J. L. Chu, and A. Parnassa. 1990. Epitope mapping of recombinant HeLa SmB and B′ peptides obtained by the polymerase chain reaction. J. Immunol. 145:636.
9. Rokeach, L. A., M. Jannatipour, and S. O. Hoch. 1991. Heterologous expression and epitope mapping of a small nuclear ribonucleoprotein-associated Sm-B/B′ autoantigen J Immunol. 144:1015.
10. Hoch, S. O., J. A. Haselby, M. Jannatipour, M. Ryder, and L. A. Rokeach. 1990. Identification of immunoreactive domains of the snRNP polypeptides Sm B/B′ and Sm D. Mol. Biol Rep. 14:169.
11. Habets, W. J., P. T. G. Sillekens, M. H Hoet, G. McAllister, M. R. Lerner, and W. J. van Venrooij. 1989. Small nuclear RNA-associated proteins are immunologically related as revealed by mapping of autoimmune reactive B-cell epitopes. Proc. Natl. Acad. Sci. USA 86:4674.
12. Habets, W. J., M. H. Hoet, and W. J. van Venrooij. 1990. Epitope patterns of anti-RNP antibodies in rheumatic diseases. Arthritis Rheum 33:834
13. Guldner, H. H., H. J. Netter, C Szostecki, H. J Lakomek, and H. Will. 1988. Epitope mapping with a recombinant human 68-kDa (U1) ribonucleoprotein antigen reveals heterogeneous autoantibody profiles in human autoimmune sera. J Immunol 141.469.
14. Netter, H. J., H. H. Guldner, C. Szostecki, and H. Will. 1990. Major autoantigenic sites of the (U1) small nuclear ribonucleoprotein-specific 68-kDa protein Scand. J. Immunol 32:163.
15. Guldner, H. H , H J Netter, C. Szostecki, E Jaeger, and H. Will. 1990. Human anti-p68 autoantibodies recognize a common epitope of U1 RNA containing small nuclear ribonucleoprotein and influenza B virus. J. Exp. Med. 171.819.
16. Netter, H. J., H. Will, C Szostecki, and H. H. Guldner. 1991. Repetitive P68-autoantigen specific epitopes recognized by human anti-(U1) small nuclear ribonucleoprotein autoantibodies. J. Autoimmunity 4:651.
17. Nyman, U., I. Lundberg, E. Hedfors, and I. Pettersson. 1990. Recombinant 70-kD protein used for determination of autoantigenic epitopes recognized by anti-RNP sera. Clin. Exp. Immunol. 81:52.
18. Takeda, Y., U. Nyman, A. Winkler, K. S. Wise, S. O. Hoch, I. Pettersson, S. K. Anderson, R. J. Wang, G. S. Wang, and G. C. Sharp. 1992 Antigenic domains on the U1 small nuclear ribonucleoprotein-associated 70K polypeptide: a comparison of regions selectively recognized by human and mouse autoantibodies and by monoclonal antibodies. Clin. Immunol. Immunopathol. 61:55.
19. Cram, D S., N. Fisicaro, R. L. Coppel, S. Whittingham, and L. C. Harrison. 1990. Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the U1 ribonucleoprotein complex. J. Immunol. 145:630.
20. Query, C C., and J D. Keene. 1987. A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30 gag antigen. Cell 51:211.
21. Hines, J. J., W. Danho, and K. B Elkon. 1991. Detection and quantification of human anti-Sm antibodies using synthetic peptide and recombinant SmB antigens. Arthritis Rheum. 34:572
22. Barakat, S., J. P. Briand, J. C. Weber, M. H. V. Regenmortel, and S. Muller. 1990 Recognition of synthetic peptides of Sm-D autoantigen by lupus sera. Clin. Exp. Immunol. 81:256.
23. Barakat, S., J. P. Briand, N. Abuaf, M. H. V Van Regenmortel, and S. Muller. Mapping of epitopes on U1 snRNP polypeptide A with synthetic peptides and autoimmune sera Clin. Exp. Immunol. 86:71.
24. James J. A , J. B Harley 1992. Linear epitope mapping of an Sm B/B′ protein. J. Immunol 148:2074.
25. James J. A., M. J. Mamula, J. B. Harley. 1994. Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL lpr/lpr antibodies. Clin. Exp. Immunol. 98:419
26. James J. A , and J. B Harley. 1995. Peptide antigenicity of the small nuclear ribonucleoprotein C. Clin Exp. Rheum. 13:299
27. James J A., R. H. Scofield, and J. B. Harley. 1994 Basic amino acids predominate in the sequential autoantigenic determinants of the small nuclear 70K ribonucleoprotein. Scand J. Immunol. 39:557.
28. James, J. A., T F. Gross, R H. Scofield, and J. B. Harley. 1995. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B′-derived PPPGMRPP and PPPGIRGP induced spliceosome autoimmunity and systemic lupus erythematosus. J. Exp. Med. 181:453.
29. Tan, E. M., A. S. Cohen, J. F. Fries, A. T. Masi, D. J. McShane, N F Rothfield, J. G. Schaller, N. Talal, and R. J Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271
30. Geysen, H. M., R. H. Meloen, and S. J. Barteling. 1984. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid Proc. Natl Acad. Sci USA 81:3998.
31. Scofield, R. H., and J. B. Harley. 1991. Autoantigenicity of Ro/SSA antigen is related to a nucleocapsid protein of vesicular stomatitis virus Proc. Natl. Acad. Sci. USA 88.3343.
32. 1991. Cleavable Peptides Kit Manual. Coselco Mimotopes Pty. Ltd., Clayton, Victoria, Australia, p. 1.
33. Merrifield, B. 1986. Solid Phase Synthesis. Science 232:341.
34. Axen, R., J. Porath, and S. Ernback. 1967. Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature 214:1302.
35. Wilchek M., T. Miron, and J. Kohn. 1984. Affinity chromotography. Methods Enzymol. 104:3.
36. Yamagata, H., J. B. Harley, and M. Reichlin. 1984. Molecular properties of the Ro/SSA antigen and enzyme-linked immunosorbent assay for quantitation of antibody. J. Clin. Invest 74:625
37. Harley, J B., A. S. Sestak, L G. Willis, S. M. Fu, J A. Hansen, and M. Reichlin. 1989. A model for disease heterogeneity in systemic lupus erythematosus relationships between histocompatibility antigens, autoantibodies and lymphopenia or renal disease Arthritis Rheum. 32:826
38. Laver, W. G., G. M Air, R. G. Webster, S. J. Smith-Gill. 1990. Epitopes on protein antigens: misconceptions and realities. Cell 61:553.
39. Huang, S -C., R H. Scofield, and J. B. Harley. 1995. Human anti-Ro autoantibodies bind peptides accessible to the surface of the native Ro autoantigen. Scand. J. Immunol. 41:220.
40. Jameson B. A., and H Wolf. 1988. The antigenic index: a novel algorithm for predicting antigenic determinants. CABIOS 4:181.
41. Nagai, K., C. Coubridge, T. H. Jessen, J. Li, and P. R. Evans 1990. Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A. Nature 348:515.
42. Scofield, R. H., W. D. Dickey, K. W. Jackson, J. A James, J. B Harley. 1991. A common autoepitope near the carboxyl terminus of the 60-kD Ro ribonucleoprotein: sequence similarity with a viral protein J. Clin. Immunol. 11:378
43. Janin, J., S. Wodak, M. Levitt, B Maigret. 1978 Conformation of amino acid side-chains in proteins. J. Mol. Biol. 125:357.
44. Berzofsky, J. A. 1985. Intrinsic and extrinsic factors in protein antigenic structure. Science 229:932.
45. Itoh, Y., and M. Reichlin. 1992. Autoantiboides to the Ro/SSA antigen are conformation dependent. I. Anti-60 kD antibodies are mainly directed to the native protein; anti-52 kD antibodies are mainly directed to the denatured protein Autoimmunity 14:57.
46. Itoh, Y., K Itoh, M. B. Frank, M. Reichlin. 1992. Autoantiboides to the Ro/SSA autoantigen are conformation dependent II. Antibodies to the denatured form of 52 kD Ro/SSA are a cross-reacting subset of antibodies to the native 60 kD Ro/SSA molecule. Autoimmunity 14:89.
47. Ohnishi, K., F. M Ebling, B. Mitchell, R. R. Singh, B.H. Hahn, B P. Tsao. 1994. Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics Int. Immunol. 6:817.
48. 1 mice J Exp. Med. 176:761.
49. Eliat, D. 1990. The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA. Mol. Immunol. 27:203.
50. Schlomchik, M., et al. 1990. Anti-DNA antibodies from autoimmune mice anse by clonal expansion and somatic mutation. J. Exp. Med. 171:265.
51. Bloom D. D , J L. Davignon, P. L. Cohen, R. A. Eisenberg, and S. H. Clarke. 1993. Overlap of the anti-Sm and anti-DNA response of MRL/Mp-lpr/lpr mice J. Immunol. 150:1579.
52. Guldner H. H. 1992. Mapping of epitopes recognized by anti-(U1)RNP autoantibodies. Mol. Biol. Rep. 16:155.
53. Bernstein, F. C , T. F. Koetzle, G. J. B. Williams, E. F. Meyer, Jr., M. D. Brice, J. R. Rodgers, O. Kennard, T. Shimanouchi, and M. Tasumi. 1977. The Protein Data Bank: a computer-based archival file for macromolecular structures J. Mol Biol 112:535.
54. Abola, E E., F. C. Bernstein, S. H. Bryant, T F. Koetzle, and J Weng. 1987. Protein Data Bank in Crystallographic Databases: Information Content, Software Systems, Scientific Applications. F. H. Allen, G. Bergerhoff, and Sievers, eds. Data Commission of the International Union of Crystallography, Bonn/Cambridge/Chester, p. 107.
55. Hoffman, D W., C. C. Query, B. L. Golden, S. W. White, and J. D Kesne 1991. RNA-binding domain of the A prtoein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. Proc. Natl. Acad. Sci. USA 88:2495.
56. Jones, T. A 1987. A graphics model building and refinement system for macromolecules. J. Appl. Crystallogr. 11:268