Operational point of neural cardiovascular regulation in humans up to 6 months in space http://www.jap.org

Journal of Applied Physiology

Volumn 108, Issue 3, 2010, Pages 646-654

  Verheyden, B ^a   Liu, J ^a   Beckers, F ^a   Aubert, A E ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Autonomic nervous system; Baroreflex; Cardiovascular physiology; Microgravity; Spaceflight

Indexed keywords

ADAPTATION; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BRACHIAL ARTERY; BREATHING MECHANICS; CARDIOVASCULAR SYSTEM; FINGER; HEART RATE; HUMAN; INNERVATION; MALE; MIDDLE AGED; ORTHOSTATIC INTOLERANCE; PATHOPHYSIOLOGY; PRESSORECEPTOR REFLEX; REACTION TIME; REPRODUCIBILITY; SPACE FLIGHT; SUPINE POSITION; TIME; VASCULARIZATION; WEIGHTLESSNESS;

ADAPTATION, PHYSIOLOGICAL; ADULT; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; BLOOD PRESSURE; BRACHIAL ARTERY; CARDIOVASCULAR SYSTEM; FINGERS; HEART RATE; HUMANS; MALE; MIDDLE AGED; ORTHOSTATIC INTOLERANCE; REACTION TIME; REPRODUCIBILITY OF RESULTS; RESPIRATORY MECHANICS; SPACE FLIGHT; SUPINE POSITION; TIME FACTORS; WEIGHTLESSNESS;

EID: 77949694769     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00883.2009     Document Type: Article

References (49)

1. Aubert AE, Beckers F, Verheyden B. Cardiovascular function and basics of physiology in microgravity. Acta Cardiol. 60: 129-151, 2005.
2. Aubert AE, Ramaekers D, Beckers F, Breem R, Denef C, Van de Werf F, Ector H. The analysis of heart rate variability in unrestrained rats. Validation of method and results. Comput Methods Programs Biomed 60: 197-213, 1999.
3. Baevsky RM, Baranov VM, Funtova II, Diedrich A, Pashenko AV, Chemikova AG, Drescher J, Jordan J, Tank J. Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station. J Appl Physiol, 103: 156-161, 2007.
4. Beckers F, Verheyden B, De Winne F, Duque P, Didier C, Aubert AE. HICOPS: human interface computer program in space. J Clin Monit Comput 18: 131-136, 2004.
5. Beckers F, Verheyden B, Liu J, Aubert AE. Cardiovascular autonomic control before, during and after short-duration spaceflights. Acta Astronaut 65: 804-812, 2009.
6. Christensen NJ, Heer M, Ivanova K, Norsk P. Sympathetic nervous activity decreases during head-down bed rest but not during microgravity. J Appl Physiol 99: 1552-1557, 2005.
7. Cooke WH, Ames JE, IV, Crossman AA, Cox JF, Kuusela TA, Tahvanainen KU, Moon LB, Drescher J, Baisch FJ, Mano T, Levine BD, Blomqvist CG, Eckberg DL. Nine months in space: effects on human autonomic cardiovascular regulation. J Appl Physiol. 89: 1039-1045, 2000.
8. Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, Sugiyama Y, Ertl AC, Biaggioni I, Diedrich A, Robertson RM, Zuckerman JH, Lane LD, Ray CA, White RJ, Pawelczyk JA, Buckey JC Jr, Baisch FJ, Blomqvist CG, Robertson D, Eckberg DL. Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre. J Physiol 538: 309-320, 2002.
9. deBoer RW, Karemaker JM, Strackee J. Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol Heart Circ Physiol 253: H680-H689, 1987.
10. Delp MD. Arterial adaptations in microgravity contribute to orthostatic tolerance. J Appl Physiol 102: 836, 2007.
11. Di Rienzo M, Castiglioni P, Iellamo F, Volterrani M, Pagani M, Maneia G, Karemaker JM, Parati G. Dynamic adaptation of cardiac baroreflex sensitivity to prolonged exposure to microgravity: data from a 16-day spaceflight. J Appl Physiol 105: 1569-1575, 2008.
12. Dorfman TA, Levine BD, Tillery T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR. Cardiac atrophy in women, following bed rest. J Appl Physiol 103: 8-16, 2007.
13. Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF, Zuckerman JH, Pawelczyk JA, Ray CA, Buckey JC Jr, Lane LD, Shiavi R, Gaffney FA, Costa F, Holt C, Blomqvist CG, Eckberg DL, Baisch FJ, Robertson D. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. J Physiol. 538: 321-329, 2002.
14. Ferretti G, Iellamo F, Pizzinelli P, Kenfack MA, Lador F, Lucini D, Porta A, Narkiewicz K, Pagani M. Prolonged head down bed restinduced inactivity impairs tonic autonomic regulation while sparing oscillatory cardiovascular rhythms in healthy humans. J Hypertens 27: 551-561, 2009.
15. Fritsch-Yelle JM, Charles JB, Jones MM, Beightol LA, Eckberg DL. Spaceflight alters autonomic regulation of arterial pressure in humans. J Appl Physiol 11: 1776-1783, 1994.
16. Fritsch-Yelle JM, Charles JB, Jones MM, Wood ML. Microgravity decreases heart rate and arterial pressure in humans. J Appl Physiol 80: 910-914, 1996.
17. Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, Zuckerman JH, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC Jr, Cooke WH, Robertson RM, Baisch FJ, Blomqvist CG, Eckberg DL, Robertson D and Biaggioni I. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol 544: 653-664, 2002.
18. Gulli G, Claydon VE, Cooper VL, Hainsworth R. R-R interval-blood pressure interaction in subjects with different tolerances to orthostatic stress. Exp Physiol 90: 367-375, 2005.
19. Hopkins WG. Measures of reliability in sports medicine and science. Sports Med 30: 1-15, 2000.
20. Iellamo F, Di Rienzo M, Lucini D, Legramante JM, Pizzinelli P, Castiglioni P, Pigozzi F, Pagani M, Parati G. Muscle metaboreflex contribution to cardiovascular regulation during dynamic exercise in microgravity: insights from mission STS-107 of the space shuttle Columbia. J Physiol 572: 829-838, 2006.
21. Imholz BP, Wieling W, van Montfrans GA, Wesseling KH. Fifteen years experience with finger arterial pressure monitoring: assessment of the technology. Cardiovasc Res 38: 605-616, 1998.
22. Keyl C, Schneider A, Dambacher M, Bernardi L. Time delay of vagally mediated cardiac baroreflex response varies with autonomic cardiovascular control. J Appl Physiol. 9.1: 283-289, 2001.
23. Koenig SC, Convertino VA, Fanton JW, Reister CA, Gaffney FA, Ludwig DA, Krotov VP, Trambovetsky EV, Latham RD. Evidence for increased cardiac compliance during exposure to simulated microgravity. Am J Physiol Regul Integr Comp Physiol 275: R1343-R1352, 1998.
24. Kozlovskaya IB, Grigoriev Al. Russian system of countermeasures on board of die International Space Station (ISS): die first results. Acta Astronaut 55: 233-237, 2004.
25. Leach CS, Alfrey CP, Suki WN, Leonard JI, Rambaut PC, Inners LD, Smith SM, Lane HW, Krauhs JM. Regulation of body fluid compartments during short-term, spaceflight. J Appl Physiol 8.1: 105-116, 1996.
26. Meek JV, Waters WW, Ziegler MG, deBlock HF, Mills PJ, Robertson D, Huang PL. Mechanisms of postspaceflight orthostatic hypotension: low α1-adrenergic receptor responses before flight and central autonomic dysregulation postflight. Am J Physiol Heart Circ Physiol 286: H1486-H1495, 2004.
27. Migeotte PF, Prisk GK, Paiva M. Microgravity alters respiratory sinus arrhythmia and short-term heart rate variability in humans. Am J Physiol Heart Circ Physiol 284: H1995-H2006, 2003.
28. Norsk P, Christensen NJ. The paradox of systemic vasodilatation and sympathetic nervous stimulation in space. Respir Physiol Neurobiol 169, Suppl 1: S26-S29, 2009.
29. Norsk P, Christensen NJ, Bie P, Gabrielsen A, Heer M, Drummer C. Unexpected renal responses in space. Lancet 356: 1577-1578, 2000.
30. Norsk P, Damgaard M, Petersen L, Gybel M, Pump B, Gabrielsen A, Christensen NJ. Vasorelaxation, in space. Hypertension 47: 69-73, 2006.
31. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 91: 645-653, 2001.
32. Pinna GD, Maestri R, Torunski A, Danilowicz-Szymanowicz L, Szwoch M, La Rovere MT, Raczak G. Heart rate variability measures: a fresh look at reliability. Clin Sci (Lond) 1.13: 131-140, 2007.
33. Preiss G, Polosa C. Patterns of sympathetic neuron activity associated with Mayer waves. Am J Physiol 226: 724-730, 1974.
34. Prisk GK, Fine JM, Cooper TK, West JB. Vital capacity, respiratory muscle strength, and pulmonary gas exchange during long-duration exposure to microgravity. J Appl Physiol. 101: 439-447, 2006.
35. Sides MB, Vernikos J, Convertino VA, Stepanek J, Tripp LD, Draeger J, Hargens AR, Kourtidou-Papadeli C, Pavy-Letraon A, Russomano T, Wong JY, Buccello RR, Lee PH, Nangalia V, Saary MJ. The Bellagio Report. Cardiovascular risks of spaceflight: implications for the future of space travel. Aviat Space Environ Med 76: 877-895, 2005.
36. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart Rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17: 354-381, 1996.
37. Taylor JA, Myers CW, Halliwill JR, Seidel H, Eckberg DL. Sympathetic restraint of respiratory sinus arrhydimia: implications for vagalcardiac tone assessment in humans. Am J Physiol Heart Circ Physiol 280: H2804-H2814, 200.1.
38. Tsuji H, Venditti FJ Jr, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D. Determinants of heart rate variability. J Am Coll. Cardiol. 28: 1539-1546, 1996.
39. Tuday EC, Meek JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance. J Appl Physiol 102: 853-858, 2007.
40. Van de Vooren H, Gademan MG, Swenne CA, TenVoorde BJ, Schalij MJ, van der Wall EE. Baroreflex sensitivity, blood pressure buffering, and resonance: what are the links? Computer simulation of healthy subjects and heart failure patients. J Appl Physiol 102: 1348-1356, 2007.
41. Verheyden B, Beckers F, Aubert AE. Spectral characteristics of heart rate fluctuations during parabolic flight. Eur J Appl Physiol 1-12, 2005.
42. Verheyden B, Beckers F, Couckuyt K, Liu J, Aubert AE. Respiratory modulation, of cardiovascular rhythms before and after short-duration human spaceflight. Acta Physiol (Oxf) 19.1: 297-308, 2007.
43. Verheyden B, Liu J, Beckers F, Aubert AE. Adaptation of heart rate and blood pressure to short and long duration space missions. Respir Physiol Neurobiol 169, Suppl 1: S13-S16, 2009.
44. Videbaek R, Norsk P. Atrial distension in humans during microgravity induced by parabolic flights. J Appl Physiol 83: 1862-1866, 1997.
45. Watenpaugh DE. Fluid volume control during short-term space flight and implications for human performance. J Exp Biol 204: 3209-3215, 2001.
46. Westerhof BE, Gisolf J, Karemaker JM, Wesseling KH, Secher NH, van Lieshout JJ. Time course analysis of baroreflex sensitivity during postural stress. Am J Physiol Heart Circ Physiol 291: H2864-H2874, 2006.
47. Westerhof BE, Gisolf J, Stok WJ, Wesseling KH, Karemaker JM. Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set. J Hypertens 11: 1371-1380, 2004.
48. White RJ, Blomqvist CG. Central venous pressure and cardiac function during spaceflight. J Appl Physiol 85: 738-746, 1998.
49. Zhang LF. Vascular adaptation to microgravity: what have we learned? J Appl. Physiol 91: 2415-2430, 2001.