β2-adrenoceptor gene polymorphisms and blood pressure variations in East Anglian Caucasians

Journal of Hypertension

Volumn 18, Issue 6, 2000, Pages 687-693

  Jia, Haiyan ^a,b   Sharma, Pankaj ^a   Hopper, Ruth ^a   Dickerson, Claire ^a   Lloyd, Deborah D ^a   Brown, Morris J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Genetics; Hypertension; Polymorphism; 2 adrenergic receptor

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR;

ADULT; AGED; AMINO TERMINAL SEQUENCE; ARTICLE; BLOOD PRESSURE; CAUCASIAN; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; UNITED KINGDOM; ALLELE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; ALLELES; BLOOD PRESSURE; ENGLAND; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, BETA; TREATMENT OUTCOME; VARIATION (GENETICS);

EID: 0033623878     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200018060-00005     Document Type: Article

References (42)

1. 1 Brodde OE, Stuka N, Demuth V, Fesel R, Bergerhausen J, Daul A, et al. Alpha-and beta-adrenoceptors in circulating blood cells of essential hypertensive patients: increased receptor density and responsiveness. Clin Exp Hypertens 1985; A7:1135-1150.
2. 2 Michel MC, Brodde OE, Insel PA. Peripheral adrenergic receptors in hypertension. Hypertension 1990; 16:107-120.
3. 3 Feldman RD, Lawton WJ, McArdle WL. Low sodium diet corrects the defect in lymphocyte beta-adrenergic responsiveness in hypertensive subjects. J Clin Invest 1987; 79:290-294.
4. 4 Stein CM, Nelson R, Deegan R, He H, Wood M, Wood AJJ. Forearm beta adrenergic receptor-mediated vasodilation is impaired, without alteration of forearm norepinephrine spillover, in borderline hypertension. J Clin Invest 1995; 96:579-585.
5. 5 Skrabal F, Kotanko P, Luft FC. Inverse regulation of alpha-2 and beta-2 adrenoceptors in salt-sensitive hypertension: an hypothesis. Life Sci 1989; 45:2061 -2076.
6. 6 Kotanko P, Hoglinger O, Skrabal F. Beta 2-adrenoceptor density in fibroblast culture correlates with human NaCl sensitivity. Am J Physiol 1992; 263:C623-C627.
7. 7 Brown MJ, Struthers AD, Burrin JM, Di Silvio L, Brown DC. The physiological and pharmacological role of presynaptic alpha-and beta-adrenoceptors in man. Br J Clin Pharmacol 1985; 20:649-658.
8. 8 Kobilka BK, Dixon RAF, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, et al. cDNA for the human beta2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 1987; 84:46-50.
9. 9 Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RAF, Keller P, et al. Delineation of the intronless nature of the genes for the human and hamster beta2-adrenergic receptor and their putative promoter regions. J Biol Chem 1987; 262:7321-7327.
10. 10 Parola AL, Kobilka BK. The peptide product of a 5′ leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis. J Biol Chem 1994; 269:4497-4505.
11. 11 Reihsaus E, Innis M, MacIntyre N, Liggett SB. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8:334-339.
12. 12 Green SA, Turki J, Innis M, Liggett SB. Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33:9414-9419.
13. 13 Green SA, Turki J, Bejarano P, Hall IP, Liggett SB. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995; 13:25-33.
14. 14 Kotanko P, Binder A, Skrabal F. Alleles of the human beta-2 adrenoceptor and their relation to salt sensitivity [Abstract]. J Hypertens 1995; 13:S97.
15. 15 Svetkey LP, Timmons PZ, Emovon O, Anderson NB, Preis L, Chen YT. Association of hypertension with beta2-and alpha(2c10)-adrenergic receptor genotype. Hypertension 1996; 27:1210-1215.
16. 16 Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJL, et al. Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension 1997; 30:773-776.
17. 17 Timmermann B, Mo R, Luft FC, Gerdts E, Busjahn A, Omvik P, et al. Beta-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: the Bergen Blood Pressure Study. Kidney Int 1998; 53:1455-1460.
18. 18 Hingorani AD, Jia H, Stevens PA, Hopper R, Dickerson JEC, Brown MJ. Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. J Hypertens 1995; 13:1602-1609.
19. 19 Brown MJ. The causes of essential hypertension. Br J Clin Pharmacol 1996; 42:21-27.
20. 20 Lahiri DK, Nurnberger JL. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucl Acid Res 1991; 19:5444.
21. 21 Weir TD, Mallek N, Sandford AJ, Bai TR, Awadh N, Fitzgerald JM, et al. Beta2-adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 1998; 158:787-791.
22. 22 Svetkey LP, Chen YT, McKeown SP, Preis L, Wilson AF. Preliminary evidence of linkage of salt sensitivity in black Americans at the beta 2-adrenergic receptor locus. Hypertension 1997; 29:918-922.
23. 23 Kunz R, Kreutz R, Beige J, Distler A, Sharma AM. Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension 1997; 30:1331-1337.
24. 24 Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, et al. Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension 1998; 31:725-729.
25. 25 Zee RY, Stephen AL, Iwai N, Morris BJ. Association analyses of S(A) gene variant in essential hypertensives. Am J Hypertens 1997; 10:235-242.
26. 26 Kamitani A, Wong ZY, Fraser R, Davies DL, Connor JM, Foy CJ, et al. Human alpha-adducin gene, blood pressure, and sodium metabolism. Hypertension 1998; 32:138-143.
27. 27 Falkner B. Differences in blacks and whites with essential hypertension: biochemistry and endocrine. State of the art lecture. Hypertension 1990; 15:681-686.
28. 28 McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest 1998; 102:1927-1932.
29. 29 Tan S, Hall IP, Dewar J, Dow E, Lipworth B. Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997; 350:995-999.
30. 30 Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-3188.
31. 31 Turki J, Pak J, Green SA, Martin RJ, Liggett SB. Genetic polymorphisms of the beta2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype. J Clin Invest 1995; 95:1635-1641.
32. 32 Gratze G, Fortin J, Labugger R, Binder A, Kotanko P, Timmermann B, et al. Beta2-adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians. Hypertension 1999; 33:1425-1430.
33. 33 Cockcroft JR, Gazis AG, White DJ, Wheatley AP, Hall IP. Association of beta2 adrenoceptor polymorphism with vascular reactivity in humans [Abstract]. Circulation 1997; 96:1-106.
34. 34 Hall IP, Wheatley A, Wilding P, Liggett SB. Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. lancer 1995; 345:1213-1214.
35. 35 Robb OJ, Webster J, Petrie JC, Harry JD, Young J. Effects of the beta 2-adrenoceptor antagonist ICI 118,551 on blood pressure in hypertensive patients known to respond to beta 1 -adrenoceptor antagonists. Br J Clin Pharmacol 1988; 25:433-438.
36. 36 Vincent HH, Man in 't Veld AJ, Boomsma F, Derkx FH, Schalekamp MA. Is beta 1 -antagonism essential for the antihypertensive action of beta-blockers? Hypertension 1987; 9:198-203.
37. 37 Dahlof B, Andren L, Svensson A, Hansson L. Antihypertensive mechanism of beta-adrenoceptor antagonism - the role of beta 2-blockade. J Hypertens 1983; 1(Suppl):112-115.
38. 38 Hall JA, Ferro A, Dickerson JEC, Brown MJ. Beta adrenoceptor subtype cross regulation in the human heart. Br Heart J 1993; 69:332-337.
39. 39 Leenen FH, Davies RA, Fourney A. Catecholamines and heart function in heart transplant patients: effects of beta1 - versus nonselective beta-blockade. Clin Pharmacol Ther 1998; 64:522-535.
40. 40 Goldstein DS, Golczynska A, Stuhlmuller J, Holmes C, Rea RF, Grossman E, et. al. A test of the 'epinephrine hypothesis' in humans. Hypertension 1999; 33:36-43.
41. 41 Stein CM, He HB, Wood AJ. Basal and stimulated sympathetic responses after epinephrine: no evidence of augmented responses. Hypertension 1998; 32:1016-1021.
42. 42 Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem 1999; 274:16694-16700.