Out cold: Biochemical regulation of mammalian hibernation - A mini-review

Gerontology

Volumn 56, Issue 2, 2010, Pages 220-230

  Storey, Kenneth B ^a  

^a CARLETON UNIVERSITY   (Canada)

Author keywords

Antioxidant defense; Hypometabolism; Metabolic rate depression; Protein phosphorylation, reversible; Torpor; Unfolded protein response

Indexed keywords

ANTIOXIDANT; CHAPERONE; MESSENGER RNA; MICRORNA; PROTEINASE; SERINE PROTEINASE INHIBITOR;

ACETYLATION; CELL FUNCTION; CRYOPRESERVATION; DNA SCREENING; HIBERNATION; HUMAN; INFLAMMATION; MAMMAL; METABOLIC INHIBITION; METABOLIC RATE; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SHORT SURVEY; SUMOYLATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; GENE EXPRESSION; HIBERNATION; HUMANS; LONGEVITY; MAMMALS; METABOLISM; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; PROTEASE INHIBITORS; SPECIES SPECIFICITY; UNFOLDED PROTEIN RESPONSE;

EID: 77949571455     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000228829     Document Type: Short Survey

References (61)

1. Maathuis MH, Leuvenink HG, Ploeg RJ: Perspectives in organ preservation. Transplantation 2007; 83: 1289-1298.
2. Collins MJ, Moainie SL, Griffith BP, Poston RS: Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool. Eur J Cardiothorac Surg 2008; 34: 318-325.
3. Storey KB, Storey JM: Metabolic rate depression in animals: transcriptional and translational controls. Biol Rev Camb Philos Soc 2004; 79: 207-233.
4. Storey KB, Storey JM: Putting life on 'pause' - molecular regulation of hypometabolism. J Exp Biol 2007; 210: 1700-1714.
5. Geiser F: Metabolic rate and body temperature reduction during hibernation and daily torpor. Annu Rev Physiol 2004; 66: 239-274.
6. Storey KB: Life in the slow lane: molecular mechanisms of estivation. Comp Biochem Physiol A 2002; 133: 733-754.
7. Danks HV: Diversity and integration of lifecycle controls in insects; in Danks HV (ed): Insect Life-Cycle Polymorphism: Theory, Evolution and Ecological Consequences for Seasonality and Diapause Control. Dordrecht, Kluwer Academic, 1994, pp 5-40.
8. Braendle C, Milloz J, Félix MA: Mechanisms and evolution of environmental responses in Caenorhabditis elegans . Curr Top Dev Biol 2008; 80: 171-207.
9. Zimmermann-Belsing T, Brabant G, Holst JJ, Feldt-Rasmussen U: Circulating leptin and thyroid dysfunction. Eur J Endocrinol 2003; 149: 257-271.
10. Tsiouris JA: Metabolic depression in hibernation and major depression: An explanatory theory and an animal model of depression. Med Hypotheses 2005; 65: 829-840.
11. Mortola JP: Implications of hypoxic hypometabolism during mammalian ontogenesis. Resp Physiol Neurobiol 2004; 141: 345-356.
12. Dark J: Annual lipid cycles in hibernators: integration of physiology and behavior. Annu Rev Nutr 2005; 25: 469-497.
13. Wang LCH, Wolowyk MW: Torpor in mammals and birds. Can J Zool 1988; 66: 133-137.
14. Zivadinović D, Marjanović M, Andjus RK: Some components of hibernation rhythms. Ann NY Acad Sci 2005; 1048: 60-68.
15. Austad SN: Diverse aging rates in metazoans: targets for functional genomics. Mech Ageing Dev 2005; 126: 43-49.
16. Brunet-Rossinni AK, Austad SN: Ageing studies on bats: a review. Biogerontology 2004; 5: 211-222.
17. Lyman CP, O'Brien RC, Greene GC, Papafrangos ED: Hibernation and longevity in the Turkish hamster Mesocricetus brandti. Science 1981; 212: 668-670.
18. Storey KB: Metabolic regulation in mammalian hibernation: enzyme and protein adaptations. Comp Biochem Physiol A 1997; 118: 1115-1124.
19. Hochachka PW: Defense strategies against hypoxia and hypothermia. Science 1986; 231: 234-241.
20. Grissom CK, Radwin MI, Scholand MB, Harmston CH, Muetterties MC, Bywater TJ: Hypercapnia increases core temperature cooling rate during snow burial. J Appl Physiol 2004; 96: 1365-1370.
21. Perlman JM: Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin Ther 2006; 28: 1353-1365.
22. Christian E, Zada G, Sung G, Giannotta SL: A review of selective hypothermia in the management of traumatic brain injury. Neurosurg Focus 2008; 25:E9.
23. Osborne PG, Gao B, Hashimoto M: Determination in vivo of newly synthesized gene expression in hamsters during phases of the hibernation cycle. Jpn J Physiol 2004; 54: 295-305.
24. Frerichs KU, Smith CB, Brenner M, DeGracia DJ, Krause GS, Marrone L, Dever TE, Hallenbeck JM: Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation. Proc Natl Acad Sci USA 1998; 95: 14511-14516.
25. Lee YJ, Miyake S, Wakita H, McMullen DC, Azuma Y, Auh S, Hallenbeck JM: Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells. J Cereb Blood Flow Metab 2007; 27: 950-962.
26. Tempé D, Piechaczyk M, Bossis G: SUMO under stress. Biochem Soc Trans 2008; 36: 874-878.
27. Morin P, Storey KB: Evidence for a reduced transcriptional state during hibernation in ground squirrels. Cryobiology 2006; 53: 310-318.
28. Malatesta M, Biggiogera M, Baldelli B, Barabino SM, Martin TE, Zancanaro C: Hibernation as a far-reaching program for the modulation of RNA transcription. Microsc Res Tech 2008; 71: 564-572.
29. Brauch KM, Dhruv ND, Hanse EA, Andrews MT: Digital transcriptome analysis indicates adaptive mechanisms in the heart of a hibernating mammal. Physiol Genom 2005; 23: 227-234.
30. Gammell P: MicroRNAs: recently discovered key regulators of proliferation and apoptosis in animal cells. Cytotechnology 2007; 53: 55-63.
31. Flynt AS, Lai EC: Biological principles of microRNA- mediated regulation: shared themes amid diversity. Nat Rev Genet 2008; 9: 831-842.
32. Baugh LR, Sternberg PW: DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest. Curr Biol 2006; 16: 780-785.
33. Morin P, Dubuc A, Storey KB: Differential expression of microRNA species in organs of hibernating ground squirrels: a role in translational suppression during torpor. Biochim Biophys Acta 2008; 1779: 628-633.
34. Chan JA, Krichevsky AM, Kosik KS: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65: 6029-6033.
35. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ: The role of microRNA-1 and micro- RNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 2006; 38:228-233.
36. Anderson P, Kedersha N: Stress granules: the Tao of RNA triage. Trends Biochem Sci 2008; 33: 141-150.
37. Williams DR, Epperson LE, Li W, Hughes MA, Taylor R, Rogers J, Martin SL, Cossins AR, Gracey AY: Seasonally hibernating phenotype assessed through transcript screening. Physiol Genom 2005: 24: 13-22.
38. Yan J, Barnes BM, Kohl F, Marr TG: Modulation of gene expression in hibernating arctic ground squirrels. Physiol Genomics 2008; 32: 170-181.
39. Crawford FI, Hodgkinson CL, Ivanova EA, Logunova LB, Evans GJ, Steinlechner S, Loudon AS: The influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus) . Physiol Genom 2007; 31: 521-530.
40. Srere HK, Belke D, Wang LC, Martin SL:α 2-Macroglobulin gene expression during hibernation in ground squirrels is independent of acute phase response. Am J Physiol 1995; 268:R1507-R1512.
41. McCarron RM, Sieckmann DG, Yu EZ, Frerichs K, Hallenbeck JM: Hibernation, a state of natural tolerance to profound reduction in organ blood flow and oxygen delivery capacity; in Storey KB (ed): Molecular Mechanisms of Metabolic Arrest. Oxford, BIOS Scientific, 2001, pp 23-42.
42. Storey KB: Gene hunting in hypoxia and exercise. Adv Exp Med Biol 2006; 588: 293-309.
43. Gettins PGW: Serpin structure, mechanism and function. Chem Rev 2002; 102: 4751-4803.
44. Carey HV, Andrews MT, Martin SL: Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature. Physiol Rev 2003; 83: 1153-1181.
45. Schröder M: Endoplasmic reticulum stress responses. Cell Mol Life Sci 2008; 65: 862-894.
46. Mamady H, Storey KB: Up-regulation of the endoplasmic reticulum molecular chaperone GRP78 during hibernation in thirteenlined ground squirrels. Mol Cell Biochem 2006; 292: 89-98.
47. Lee M, Choi I, Park K: Activation of stress signaling molecules in bat brain during arousal from hibernation. J Neurochem 2002; 82: 867-873.
48. Mamady H, Storey KB: Coping with stress: expression of ATF4, ATF6 and downstream targets in organs of hibernating ground squirrels. Arch Biochem Biophys 2008; 477: 77-85.
49. Hermes-Lima M, Storey JM, Storey KB: Antioxidant defenses and animal adaptation to oxygen availability during environmental stress; in Storey KB, Storey JM (eds): Cell and Molecular Responses to Stress. Amsterdam, Elsevier, 2001, vol 2, pp 263-287.
50. Muleme HM, Walpole AC, Staples JF: Mitochondrial metabolism in hibernation: metabolic suppression, temperature effects, and substrate preferences. Physiol Biochem Zool 2006; 79: 474-483.
51. Buzadzic B, Spasic M, Saicic ZS, Radojicic R, Petrovic VM, Halliwell B: Antioxidant defenses in the ground squirrel Citellus citellus . 2. The effect of hibernation. Free Radic Biol Med 1990; 9: 407-413.
52. Drew KL, Toien O, Rivera PM, Smith MA, Perry G, Rice ME: Role of the antioxidant ascorbate in hibernation and warming from hibernation. Comp Biochem Physiol C 2002; 133: 483-492.
53. Tan DX, Manchester LC, Sainz RM, Mayo JC, León J, Reiter RJ: Physiological ischemia/ reperfusion phenomena and their relation to endogenous melatonin production: a hypothesis. Endocrine 2005; 27: 149-158.
54. Okamoto I, Kayano T, Hanaya T, Arai S, Ikeda M, Kurimoto M: Up-regulation of an extracellular superoxide dismutase-like activity in hibernating hamsters subjected to oxidative stress in mid- to late arousal from torpor. Comp Biochem Physiol C 2006; 144: 47-56.
55. Ohta H, Okamoto I, Hanaya T, Arai S, Ohta T, Fukuda S: Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation. Comp Biochem Physiol C 2006; 143: 484-491.
56. Morin P, Ni Z, McMullen DC, Storey KB: Expression of Nrf2 and its downstream gene targets in hibernating thirteen-lined ground squirrels, Spermophilus tridecemlineatus. Mol Cell Biochem 2008; 312: 121-129.
57. Morin P, Storey KB: Antioxidant defense in hibernation: cloning and expression of peroxiredoxins from hibernating ground squirrels, Spermophilus tridecemlineatus. Arch Biochem Biophys 2007; 461: 59-65.
58. Ishii T, Yanagawa T: Stress-induced peroxiredoxins. Subcell Biochem 2007; 44: 375-384.
59. Murphy CT: The search for DAF-16/FOXO transcriptional targets: approaches and discoveries. Exp Gerontol 2006; 41: 910-921.
60. Ambros JT, Herrero-Fresneda I, Borau OG, Boira JM: Ischemic preconditioning in solid organ transplantation: from experimental to clinics. Transpl Int 2007; 20: 219-229.
61. Kämäräinen A, Virkkunen I, Tenhunen J: Hypothermic preconditioning of donor organs prior to harvesting and ischaemia using ice-cold intravenous fluids. Med Hypotheses 2009; 73: 65-66.