Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates

Carbohydrate Research

Volumn 345, Issue 6, 2010, Pages 761-767

  Saraiva, Maurício F ^a   de Souza, Marcus V N ^b   Tran Huu Dau, Marie E ^c   Araújo, Débora P ^a   de Carvalho, Gustavo S G ^a   de Almeida, Mauro V ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c CNRS   (France)

Author keywords

Carbohydrate; Fluoroquinolones; Microwave activation; Tuberculosis

Indexed keywords

CLASSICAL REACTIONS; FLUOROQUINOLONES; MICROWAVE ACTIVATION; MOXIFLOXACIN; REACTION TIME;

CARBOHYDRATES; CHEMICAL MODIFICATION; MICROWAVE IRRADIATION;

SYNTHESIS (CHEMICAL);

1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 7 [4 (METHYL 2,3,4 TRI O ACETYL 6 DEOXY ALPHA DEXTRO GLUCOPYRANOSID 6 YL) 1 PIPERAZINYL] 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 HYDROXY 7 [3 METHYL 4 (METHYL 2,3,4 TRI O ACETYL 6 DEOXY ALPHA DEXTRO GLUCOPYRANOSID 6 YL) 1 PIPERAZINYL] 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 8 METHOXY 7 [1 (METHYL 2,3,4 TRI O ACETYL 6 DEOXY ALPHA DEXTRO GLUCOPYRANOSID 6 YL) OCTAHYDRO 6H PYRROLO[3,4 B]PYRIDIN 6 YL] 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [1 (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YL) OCTAHYDRO 6H PYRROLO[3,4 B]PYRIDIN 6 YL] 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [4 (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YL) 1 PIPERAZINYL] 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [4 (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YL) 3 METHYL 1 PIPERAZINYL] 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [N (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YL AMINOETHYLAMINO)] 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [N (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YL AMINOPROPYLAMINO)] 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINE CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [N (6 DEOXY 1,2:3,4 DI O ISOPROPYLIDENE ALPHA DEXTRO GALACTOPYRANOS 6 YLAMINOPROPYLAMINO)] 6 FLUORO 1,4 DIHYDRO 8 METHOXY 4 OXO 3 QUINOLINE CARBOXYLIC ACID; CARBOHYDRATE; CIPROFLOXACIN; ETHAMBUTOL; GATIFLOXACIN; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH TEMPERATURE; MICROWAVE IRRADIATION; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTITUBERCULAR AGENTS; AZA COMPOUNDS; CARBOHYDRATES; CIPROFLOXACIN; FLUOROQUINOLONES; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; QUINOLINES;

EID: 77949569109     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2010.01.016     Document Type: Article

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