Bone marrow osteoblastic niche: A new model to study physiological regulation of megakaryopoiesis

PLoS ONE

Volumn 4, Issue 12, 2009, Pages

  Pallotta, Isabella ^a,b   Lovett, Michael ^a   Rice, William ^a   Kaplan, David L ^a   Balduini, Alessandra ^a,b  

^a Tufts University   (United States)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; CELL CONTACT; CELL CULTURE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MESENCHYMAL STEM CELL; OSSIFICATION; OSTEOBLAST; OXYGEN TENSION; PROTEIN SECRETION; STEM CELL NICHE; BIOLOGICAL MODEL; BONE MARROW CELL; CELL SHAPE; CYTOLOGY; METABOLISM; PHYSIOLOGY; REPRODUCIBILITY; THROMBOCYTE;

BLOOD PLATELETS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL HYPOXIA; CELL SHAPE; COLLAGEN TYPE I; HEMATOPOIETIC STEM CELLS; HUMANS; INTEGRIN ALPHA2BETA1; INTEGRIN ALPHA4BETA1; MEGAKARYOCYTES; MESENCHYMAL STEM CELLS; MODELS, BIOLOGICAL; OSTEOBLASTS; REPRODUCIBILITY OF RESULTS;

EID: 77949534952     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008359     Document Type: Article

References (46)

1. Patel SR, Hartwig JH, Italiano JE (2005) The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest 115: 3348-3354.
2. Schulze H, Shivdasani RA (2005) Mechanisms of thrombopoiesis. J Thromb Haemost 3: 1717-1724.
3. Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, et al. (2004) Chemokine- mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 10: 64-71.
4. Larson MK, Watson SP (2006) A product of their environment: do megakaryocytes rely on extracellular cues for proplatelet formation? Platelets 17: 435-440.
5. Leven RM, Tablin F (1992) Extracellular matrix stimulation of guinea pig megakaryocyte proplatelet formation in vitro is mediated through the vitronectin receptor. Exp Hematol 20: 1316-1322.
6. Balduini A, Pallotta I, Malara A, Lova P, Pecci A, et al. (2008) Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. J Thromb Haemost 6: 1900-1907.
7. Nilsson SK, Debatis ME, Dooner MS, Madri JA, Quesenberry PJ, et al. (1998) Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ. J Histochem Cytochem 46: 371-377.
8. Larson MK, Watson SP (2006) Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Blood 108: 1509-1514.
9. Reddi AH, Gay R, Gay S, Miller EJ (1977) Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 74: 5589-5592.
10. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, et al. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841-846.
11. Kacena MA, Gundberg CM, Horowitz MC (2006) A reciprocal regulatory interaction between megakaryocytes, bone cells, and hematopoietic stem cells. Bone 39: 978-984.
12. Arai F, Suda T (2007) Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci 1106: 41-53.
13. Sabri S, Jandrot-Perrus M, Bertoglio J, Farndale RW, Mansat-DeMas V, et al. (2004) Differential regulation of actin stress fiber assembly and proplatelet formation by a2b1 integrin and GPVI in human megakaryocytes. Blood 104: 3117-3125.
14. Sabri S, Foudi A, Boukour S, Franc B, Charrier S, et al. (2006) Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood 108: 134-340.
15. Seib FP, Muller K, Franke M, Grimmer M, Bornhauser M, et al. (2009) Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells. Tissue Eng Part A. In press.
16. Chow DC, Wenning LA, Miller WM, Papoutsakis ET (2001) Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models. Biophys J 81: 685-696.
17. Lord BI (1990) The architecture of bone marrow cell populations. Int J Cell Cloning 8: 317-331.
18. Mostafa SS, Miller WM, Papoutsakis ET (2000) Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes. Br J Haematol 111: 879-889.
19. Porter RL, Calvi LM (2008) Communications between bone cells and hematopoietic stem cells. Arch Biochem Biophys 473: 193-200.
20. Williams N, Levine RF (1982) The origin, development and regulation of megacaryocytes. Br J Haematol 52: 173-180.
21. Rajashekhar G, Loganath A, Roy AC, Chong SS, Wong YC (2005) Hypoxia up- regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts. J Soc Gynecol Investig 12: 310-9.
22. Willam C, Schindler R, Frei U, Eckardt KU (1999) Increases in oxygen tension stimulates expression of ICAM-1 and VCAM-1 on human endothelial cells. Am J Physiol 276: 2044-52.
23. Majumdar MK, Thiede MA, Haynesworth SE, Bruder SP, Gerson SL (2000) Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J Hematother Stem Cell Res 9(6): 841-848.
24. Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, et al. (2007) The May-Hegglin anomaly gene Myh9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood 100: 171-179.
25. Nurden P, Debili N, Vainchenker W, Bobe R, Bredoux R, et al. (2006) Impaired megakaryocytopoiesis in type 2B von Willebrand disease with severe thrombocytopenia. Blood 108: 2587-2595.
26. Pecci A, Malara A, Bauducco A, Bozzi V, Torti M, et al. (2009) Megakaryocytes of patients with myh9-related thrombocytopenia present an altered proplatelet formation. Thrombosis and Haemostasis. In press.
27. Rice WL, Firdous S, Gupta S, Hunter M, Foo CW, et al. (2008) Non-invasive characterization of structure and morphology of silk fibroin biomaterials using non-linear microscopy. Biomaterials 29: 2015-2024.
28. Georgakoudi I, Rice WL, Hronik-Tupaj M, Kaplan DL (2008) Optical spectroscopy and imaging for the noninvasive evaluation of engineered tissues. Tissue Eng Part B Rev 14: 321-340.
29. Junt T, Schulze H, Chen Z, Massberg S, Goerge T, et al. (2007) Dynamic visualization of thrombopoiesis within bone marrow. Science 317: 1767-1770.
30. Xie Y, Yin T, Wiegraebe W, He XC, Miller D, et al. (2009) Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457: 97-101.
31. Warren SM, Steinbrech DS, Mehrara BJ, Saadeh PB, Greenwald JA, et al. (2001) Hypoxia regulates osteoblast gene expression. J Surg Res 99: 147-155.
32. Hirao M, Hashimoto J, Yamasaki N, Ando W, Tsuboi H, et al. (2007) Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes. J Bone Miner Metab 25: 266-276.
33. Yin T, Li L (2006) The stem cell niches in bone. J Clin Invest 116: 1195-1201.
34. Zou Z, Schmaier AA, Cheng L, Mericko P, Dickeson SK, et al. (2009) Negative regulation of activated {alpha}2 integrins during thrombopoiesis. Blood. In press.
35. Maupin P, Phillips CL, Adelstein RS, Pollard TD (1994) Differential localization of myosin-II isozymes in human cultured cells and blood cells. J Cell Sci 107: 3077-3090.
36. The May-Hegglin/Fechtner Syndrome Consortium (2000) Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium. Nat Genet 26: 103-105.
37. Chang Y, Auradé F, Larbret F, Zhang Y, Le Couedic JP, et al. (2007) Proplatelet formation is regulated by the Rho/ROCK pathway. Blood 109: 4229-4236.
38. Dorshkind K (1990) Regulation of hemopoiesis by bone marrow stromal cells and their products. Annu Rev Immunol 8: 111-137.
39. Cheng L, Qasba P, Vanguri P, Thiede MA (2000) Human mesenchymal stem cells support megakaryocyte and pro-platelet formation from CD34(+) hematopoietic progenitor cells. J Cell Physiol 184: 58-69.
40. Liu F, Akiyama Y, Tai S, Maruyama K, Kawaguchi Y, et al. (2008) Changes in the expression of CD106, osteogenic genes, and transcription factors involved in the osteogenic differentiation of human bone marrow mesenchymal stem cells. J Bone Miner Metab 26: 312-320.
41. Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, et al. (2008) Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals. Exp Hematol 36: 897-906.
42. Balduini A, Malara A, Pecci A, Badalucco S, Bozzi V, et al. (2009) Proplatelet formation in heterozygous Bernard-Soulier syndrome type Bolzano. J Thromb Haemost 7: 478-484.
43. Wang Y, Kim UJ, Blasioli DJ, Kim HJ, Kaplan DL (2005) In vitro cartilage tissue engineering with 3D porous aqueous-derived silk scaffolds and mesenchymal stem cells. Biomaterials 26: 7082-7094.
44. Woessner JF Jr (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch Biochem Biophys 93: 440-447.
45. Neuman RE, Logan MA (1950) The determination of collagen and elastin in tissues. J Biol Chem 186: 549-556.
46. Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, et al. (2004) Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood- derived human megakaryocytes. Exp Cell Res 300: 84-93.