Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 877-882

  Mae, Shin Ichi ^a   Shirasawa, Sakiko ^b   Yoshie, Susumu ^a   Sato, Fumi ^a   Kanoh, Yoshiya ^a   Ichikawa, Hinako ^a   Yokoyama, Tadayuki ^b   Yue, Fengming ^a   Tomotsune, Daihachiro ^a   Sasaki, Katsunori ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b BOURBON Corporation   (Japan)

Author keywords

BMP7; Intermediate mesoderm; Mouse embryonic stem cell; Small molecule

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CELL MARKER; OSTEOGENIC PROTEIN 1; PROTEIN ODD SKIPPED RELATED 1; RETINOIC ACID; TRANSCRIPTION FACTOR PAX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CONTROLLED STUDY; ECTODERM; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; ENDODERM; GENE EXPRESSION; KIDNEY DEVELOPMENT; MESODERM; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANILIDES; ANIMALS; BENZAMIDES; BONE MORPHOGENETIC PROTEIN 7; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; CHROMONES; COCULTURE TECHNIQUES; EMBRYONIC STEM CELLS; GENE EXPRESSION; GENETIC MARKERS; JANUS KINASES; KIDNEY; MESODERM; MICE; MORPHOLINES; PROTEIN KINASE INHIBITORS; REGENERATION;

EID: 77949492380     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.111     Document Type: Article

References (38)

1. Doetschman T.C., Eistetter H., Katz M., et al. The in vitro development of blastocyst-derived embryonic stem cell line: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87 (1985) 27-45
2. Nishikawa S.I., Nishikawa S., Hirashima M., et al. Progressive lineage analysis by cell sorting and culture identifies FLK+VE-cadherin cells at a diverging point of endothelial and hematopoietic lineages. Development 125 (1998) 1747-1757
3. Ding S., and Schultz P.G. A role for chemistry in stem cell biology. Nat. Biotechnol. 22 (2004) 833-840
4. Chen S., Borowiak M., Fox J.L., et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat. Chem. Biol. 5 (2009) 258-265
5. Steenhard B.M., Isom K.S., Cazzcarro P., et al. Integration of embryonic stem cells in metanephric kidney organ culture. J. Am. Soc. Nephrol. 16 (2005) 1623-1631
6. Kobayashi T., Tanaka H., Kuwana H., et al. Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem. Biophys. Res. Commun. 336 (2005) 585-595
7. Kim D., and Dressler G.R. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J. Am. Soc. Nephrol. 16 (2005) 3527-3534
8. Niwa H., Burdon T., Chambers I., et al. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12 (1998) 2048-2060
9. Niwa H., Ogawa K., Shimosato D., et al. A parallel circuit of LIF signaling pathways maintains pluripotency of mouse ES cells. Nature 460 (2009) 118-122
10. Androutsllis-Theotokis A., Leker R.R., Soldner F., et al. Notch signaling regulates stem cell numbers in vitro and in vivo. Nature 442 (2006) 823-826
11. Rogers M.B., Hosler B.A., and Gudas L.J. Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex1, in preimplantation embryos, trophoblast and spermatocytes. Development 113 (1991) 815-824
12. Hébert J.M., Boyle M., and Martin G.M. MRNA localization studies suggest that murine FGF-5 plays a role in gastrulation. Development 112 (1991) 407-415
13. Pelton T.A., Sharma S., Schulz T.C., et al. Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J. Cell Sci. 115 (2002) 329-339
14. Tesar P.J., Chenoweth J.G., Brook F.A., et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448 (2007) 196-199
15. Wilkinson D.G., Bhatt S., and Herrmann B.G. Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343 (1990) 657-659
16. Ciruna B.G., and Rossant J. Expression of the T-box gene Eomesodermin during early mouse development. Mech. Dev. 81 (1999) 199-203
17. Dziadek M. Cell differentiation in isolated inner cell masses of mouse blastocysts in vitro: onset of specific gene expression. J. Embryol. Exp. Morphol. 53 (1979) 367-379
18. James R.G., Kamei C.N., Wang Q., et al. Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development 133 (2006) 2995-3004
19. Wang Q., Lan Y., Cho E.S., et al. Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development. Dev. Biol. 288 (2005) 582-594
20. McLean A.B., D'Amour K.A., Jones K.L., et al. Activin A efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 25 (2007) 29-38
21. Takahashi K., Murakami M., and Yamanaka S. Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem. Soc. Trans. 33 (2005) 1522-1525
22. Nakaya Y., Sukowati E.W., Wu Y., et al. RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation. Nat. Cell Biol. 10 (2008) 756-775
23. Evelyn C.R., Wade S.M., Wang Q., et al. CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol. Cancer Ther. 6 (2007) 2249-2260
24. Aubert J., Stavridis M.P., Tweedie S., et al. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc. Natl. Acad. Sci. USA 100 (2003) 11836-11841
25. Sakurai H., Era T., Jakt L.M., et al. In vitro modeling of paraxial and lateral mesoderm differentiation reveals early reversibility. Stem Cells 24 (2006) 575-586
26. Archdeacon P., and Detwiler P.K. Bone morphogenetic protein 7 (BMP7): a critical role in kidney development and a putative modulator of kidney injury. Adv. Chronic Kidney Dis. 15 (2008) 314-320
27. Blank U., Brown A., Adams D.C., et al. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development 136 (2009) 3557-3566
28. Bouchard M., Souabni A., Mandler M., et al. Nephric lineage specification by Pax2 and Pax8. Genes Dev. 16 (2002) 2958-2970
29. Tsang T.E., Shawlot W., Kinder S.J., et al. Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Dev. Biol. 223 (2000) 77-90
30. Mugford J.W., Sipilä P., McMahon J.A., et al. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev. Biol. 324 (2008) 88-98
31. Guillaume R., Bressan M., and Herzlinger D. Paraxial mesoderm contributes stromal cells to the developing kidney. Dev. Biol. 329 (2009) 169-175
32. Sainio K., Nonclercq D., Saarma M., et al. Neuronal characteristics in embryonic renal stroma. Int. J. Dev. Biol. 38 (1994) 77-84
33. Nornes H.O., Dressler G.R., Knapik E.W., et al. Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development 109 (1990) 797-809
34. Sherwood R.I., Jitianu C., Cleaver O., et al. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev. Biol. 304 (2007) 541-555
35. Kim J., Chu J., Shen X., et al. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132 (2008) 1049-1061
36. Mugford J.W., Sipilä P., Kobayashi A., et al. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of mouse embryo. Dev. Biol. 319 (2008) 396-405
37. Noon E.P., Barak H., Guttmann-Raviv N., et al. Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field. Development 136 (2009) 1995-2004
38. Duester G. Retinoic acid regulation of the somitogenesis clock. Birth Defects Res. C: Embryo Today 81 (2007) 84-92