Phosphaisocoumarins as a new class of potent inhibitors for pancreatic cholesterol esterase

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1955-1963

  Li, Baojian ^a   Zhou, Binhua ^a   Lu, Hailiang ^a   Ma, Lin ^a   Peng, Ai Yun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cholesterol esterase; Inhibitor; Isocoumarin; Phosphaisocoumarin

Indexed keywords

1 ETHOXY 4 IODO 3 ( 4 METHOXYPHENYL)BENZO[C][ 1,2 ]OXAPHOSPHININE 1 OXIDE; 1 ETHOXY 7 METHOXY 1 OXO 1H 1 LAMBDA 5 BENZO[C][ 1,2 ]OXAPHOSPHININ 3 YL METHANOL; 4 BROMO 1 ETHOXY 3 ( 4 METHOXYPHENYL)BENZO[C][ 1,2 ]OXAPHOSPHININE 1 OXIDE; 5 CHLORO 2 [2 ( 4 METHOXYPHENYL)ETHYNYL]PHENYLPHOSPHONIC ACID DIETHYL ESTER; 7 CHLORO 1 ETHOXY 3 PHENYL 4 (BENZOYLMETHYL)BENZO[C][ 1,2 ]OXAPHOSPHININE 1 OXIDE; 7 CHLORO 1 ETHOXY 3 PHENYL 4 PHENYLETHYNYLBENZO[C][ 1,2 ]OXAPHOSPHININE 1 OXIDE; CHOLESTEROL ESTERASE; ESTERASE INHIBITOR; ISOCOUMARIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG INHIBITION; DRUG POTENCY; ENZYME INHIBITION; IC 50; PANCREAS; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; ISOCOUMARINS; KINETICS; MOLECULAR STRUCTURE; PANCREAS; STEREOISOMERISM; STEROL ESTERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 77949491615     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.038     Document Type: Article

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