Tetrahydroindolizinone NK1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2354-2358

  Bao, Jianming ^a   Lu, Huagang ^a   Morriello, Gregori J ^a   Carlson, Emma J ^a   Wheeldon, Alan ^a   Chicchi, Gary G ^a   Kurtz, Marc M ^a   Tsao, Kwei Lan C ^a   Zheng, Song ^a   Tong, Xinchun ^a   Mills, Sander G ^a   DeVita, Robert J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonists; Gerbil foot tapping; IP1; NK1; Tetrahydroindolizinone

Indexed keywords

LACTONE DERIVATIVE; NEUROKININ 1 RECEPTOR ANTAGONIST; OXADIAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; TETRAHYDROINDOLIZINONE; UNCLASSIFIED DRUG; INDOLIZINE DERIVATIVE; NEUROKININ 1 RECEPTOR;

AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; GERBIL; HUMAN; METABOLISM;

GERBILLINAE;

ANIMALS; GERBILLINAE; HUMANS; INDOLIZINES; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77949486988     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.120     Document Type: Article

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