Controversies concerning the diagnosis and treatment of bipolar disorder in children

Child and Adolescent Psychiatry and Mental Health

Volumn 4, Issue , 2010, Pages

  Parens, Erik ^a   Johnston, Josephine ^a  

^a HASTINGS CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CARBAMAZEPINE; HALOPERIDOL; LITHIUM SALT; MOOD STABILIZER; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; PSYCHOSTIMULANT AGENT; QUETIAPINE; RISPERIDONE; VALPROATE SEMISODIUM;

BIPOLAR DISORDER; CHILD BEHAVIOR; CHILD PSYCHIATRY; CLINICAL FEATURE; COGNITIVE THERAPY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIAGNOSTIC ERROR; DISRUPTIVE BEHAVIOR; DOCTOR PATIENT RELATION; DROWSINESS; DRUG EFFICACY; DRUG RESPONSE; DYSKINESIA; FAMILY THERAPY; HUMAN; INFORMED CONSENT; INTERNATIONAL CLASSIFICATION OF DISEASES; MEDICAL ETHICS; METABOLIC DISORDER; NOTE; PREVALENCE; PRIORITY JOURNAL; PSYCHOEDUCATION; PSYCHOSOCIAL CARE; RESTLESSNESS; SIDE EFFECT; SPEECH DISORDER; TARDIVE DYSKINESIA; UNITED STATES; WEIGHT GAIN;

EID: 77949481698     PISSN: None     EISSN: 17532000     Source Type: Journal    
DOI: 10.1186/1753-2000-4-9     Document Type: Note

References (85)

1. Moreno C, Laje G, Blanco C, Jiang H, Schmidt AB, Olfson M. National trends in the outpatient diagnosis and treatment of bipolar disorder in youth. Arch Gen Psychiatry 2007, 64:1032-1039. 10.1001/archpsyc.64.9.1032, 17768268.
2. Wilens TE, Biederman J, Brown S, Tanguay S, Monuteaux MC, Blake C, Spencer TJ. Psychiatric comorbidity and functioning in clinically referred preschool children and school-age youths with ADHD. J Am Acad Child Adolesc Psychiatry 2002, 41:262-268. 10.1097/00004583-200203000-00005, 11886020.
3. Olfson M, Crystal S, Huang C, Gerhard T. Trends in Antipsychotic Drug Use by Very Young, Privately Insured Children. J Am Acad Child Adolesc Psychiatry 2010, 49:13-23. 10.1097/00004583-201001000-00005, 20215922.
4. Parens E, Johnston J. Understanding the agreements and controversies surrounding childhood psychopharmacology. Child Adolesc Psychiatry Ment Health 2008, 2:5. 10.1186/1753-2000-2-5, 2275214, 18261228.
5. Parens E, Johnston J. Facts, values, and Attention-Deficit Hyperactivity Disorder (ADHD): an update on the controversies. Child Adolesc Psychiatry Ment Health 2009, 3:1. 10.1186/1753-2000-3-1, 2637252, 19152690.
6. Papolos D, Papolos J. The Bipolar Child 2000, New York: Broadway Books.
7. Kluger J, Song S. Young and bipolar. Time 2002, 160:38-46.
8. Miklowitz DJ, Biuckians A, Richards JA. Early-onset bipolar disorder: a family treatment perspective. Dev Psychopathol 2006, 18:1247-1265.
9. Sund A, Wichstrom L. Insecure attachment as a risk factor for future depressive symptoms in early adolescence. J Am Acad Child Adolesc Psychiatry 2002, 41:1478. 10.1097/00004583-200212000-00020, 12447035.
10. Birmaher B, Axelson D, Strober M, Gill MK, Valeri S, Chiappetta L, Ryan N, Leonard H, Hunt J, Iyengar S, et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 2006, 63:175-183. 10.1001/archpsyc.63.2.175, 16461861.
11. Wozniak J, Biederman J, Kiely K, Ablon JS, Faraone SV, Mundy E, Mennin D. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry 1995, 34:867-876.
12. Biederman J, Mick E, Faraone SV, Van Patten S, Burback M, Wozniak J. A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorder. J Affect Disord 2004, 82(Suppl 1):S17-S23. 10.1016/j.jad.2004.05.012, 15571786.
13. Biederman J, Faraone SV, Wozniak J, Mick E, Kwon A, Aleardi M. Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 years. J Affect Disord 2004, 82(Suppl 1):S45-S58. 10.1016/j.jad.2004.05.021, 15571789.
14. Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL, DelBello MP, Soutullo CA. Diagnostic characteristics of 93 cases of a prepubertal and early adolescent bipolar disorder phenotype by gender, puberty and comorbid attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 2000, 10:157-164. 10.1089/10445460050167269, 11052405.
15. Kluger J, Song S. Young and Bipolar. TIME 2002,
16. Egan J. The Bipolar Puzzle. New York Magazine 2008,
17. Martin E. Bipolar Expeditions: Mania and Depression in American Culture 2007, Princeton, NJ: Princeton University Press.
18. Tereskerz PM, Hamric AB, Guterbock TM, Moreno JD. Prevalence of industry support and its relationship to research integrity. Account Res 2009, 16:78-105. 2758529, 19353387.
19. Spielmans G, Parry P. From Evidence-based Medicine to Marketing-based Medicine: Evidence from Internal Industry Documents. Journal of Bioethical Inquiry 2010,
20. Healy D. The latest mania: selling bipolar disorder. PLoS Med 2006, 3:e185. 10.1371/journal.pmed.0030185, 1434505,1434505, 16597178.
21. Campbell EG, Weissman JS, Ehringhaus S, Rao SR, Moy B, Feibelmann S, Goold SD. Institutional academic industry relationships. JAMA 2007, 298:1779-1786. 10.1001/jama.298.15.1779, 17940234.
22. Angell M. Industry-sponsored clinical research: a broken system. JAMA 2008, 300:1069-1071. 10.1001/jama.300.9.1069, 18768418.
23. Smith R. Medical journals are an extension of the marketing arm of pharmaceutical companies. PLoS Med 2005, 2:e138. 10.1371/journal.pmed.0020138, 1140949, 15916457.
24. Brennan TA, Rothman DJ, Blank L, Blumenthal D, Chimonas SC, Cohen JJ, Goldman J, Kassirer JP, Kimball H, Naughton J, et al. Health industry practices that create conflicts of interest: a policy proposal for academic medical centers. JAMA 2006, 295:429-433. 10.1001/jama.295.4.429, 16434633.
25. DeAngelis CD, Fontanarosa PB. Impugning the integrity of medical science: the adverse effects of industry influence. JAMA 2008, 299:1833-1835. 10.1001/jama.299.15.1833, 18413880.
26. Carlson GA, Glovinsky I. The concept of bipolar disorder in children: a history of the bipolar controversy. Child Adolesc Psychiatr Clin N Am 2009, 18:257-71. vii, 10.1016/j.chc.2008.11.003, 19264263.
27. Carlson GA. Bipolar affective disorder in childhood and adolescence. Affective disorders in childhood and adolescence 1983, New York: Spectrum, Cantwell DP, Carlson GA.
28. Leibenluft E, Rich BA. Pediatric bipolar disorder. Annu Rev Clin Psychol 2008, 4:163-187. 10.1146/annurev.clinpsy.4.022007.141216, 17716034.
29. Geller B, Sun K, Zimerman B, Luby J, Frazier J, Williams M. Complex and rapid-cycling in bipolar children and adolescents: a preliminary study. J Affect Disord 1995, 34:259-268. 10.1016/0165-0327(95)00023-G, 8550951.
30. Biederman J, Wozniak J, Kiely K, Ablon S, Faraone S, Mick E, Mundy E, Kraus I. CBCL clinical scales discriminate prepubertal children with structured interview-derived diagnosis of mania from those with ADHD. J Am Acad Child Adolesc Psychiatry 1995, 34:464-471.
31. Geller B, Fox LW, Clark KA. Rate and predictors of prepubertal bipolarity during follow-up of 6- to 12-year-old depressed children. J Am Acad Child Adolesc Psychiatry 1994, 33:461-468. 10.1097/00004583-199405000-00003, 8005898.
32. Task Force on DSM-IV and other committees and work groups of the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2004, Washington, DC: American Psychiatric Association, Task Force on DSM-IV and other committees and work groups of the American Psychiatric Association.
33. Soutullo CA, Chang KD, Diez-Suarez A, Figueroa-Quintana A, Escamilla-Canales I, Rapado-Castro M, Ortuno F. Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology. Bipolar Disord 2005, 7:497-506. 10.1111/j.1399-5618.2005.00262.x, 16403175.
34. Biederman J, Faraone SV, Wozniak J, Mick E, Kwon A, Cayton GA, Clark SV. Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents. J Psychiatr Res 2005, 39:611-622. 10.1016/j.jpsychires.2004.08.003, 16009376.
35. Geller B, Zimerman B, Williams M, DelBello MP, Bolhofner K, Craney JL, Frazier J, Beringer L, Nickelsburg MJ. DSM-IV mania symptoms in a prepubertal and early adolescent bipolar disorder phenotype compared to attention-deficit hyperactive and normal controls. J Child Adolesc Psychopharmacol 2002, 12:11-25. 10.1089/10445460252943533, 12014591.
36. Hunt JI, Dyl J, Armstrong L, Litvin E, Sheeran T, Spirito A. Frequency of manic symptoms and bipolar disorder in psychiatrically hospitalized adolescents using the K-SADS Mania Rating Scale. J Child Adolesc Psychopharmacol 2005, 15:918-930. 10.1089/cap.2005.15.918, 16379512.
37. Sigurdsson E, Fombonne E, Sayal K, Checkley S. Neurodevelopmental antecedents of early-onset bipolar affective disorder. Br J Psychiatry 1999, 174:121-127. 10.1192/bjp.174.2.121, 10211165.
38. Scully PJ, Owens JM, Kinsella A, Waddington JL. Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate. Schizophr Res 2004, 67:143-155. 10.1016/S0920-9964(03)00194-4, 14984873.
39. Tramontina S, Schmitz M, Polanczyk G, Rohde LA. Juvenile bipolar disorder in Brazil: clinical and treatment findings. Biol Psychiatry 2003, 53:1043-1049. 10.1016/S0006-3223(03)00008-8, 12788249.
40. Kramer P. Listening to Prozac 1993, New York: Viking.
41. Croonenberghs J, Fegert JM, Findling RL, De Smedt G, Van Dongen S. Risperidone in children with disruptive behavior disorders and subaverage intelligence: a 1-year, open-label study of 504 patients. J Am Acad Child Adolesc Psychiatry 2005, 44:64-72. 10.1097/01.chi.0000145805.24274.09, 15608545.
42. McCracken JT, McGough J, Shah B, Cronin P, Hong D, Aman MG, Arnold LE, Lindsay R, Nash P, Hollway J, et al. Risperidone in children with autism and serious behavioral problems. N Engl J Med 2002, 347:314-321. 10.1056/NEJMoa013171, 12151468.
43. Tillman R, Geller B. Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors. Dev Psychopathol 2006, 18:1037-1053. 10.1017/S0954579406060512, 17064428.
44. Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry 2004, 55:875-881. 10.1016/j.biopsych.2004.01.022, 15110730.
45. McClellan J. Commentary: treatment guidelines for child and adolescent bipolar disorder. J Am Acad Child Adolesc Psychiatry 2005, 44:236-239. 10.1097/00004583-200503000-00007, 15725967.
46. Kowatch RA, Fristad M, Birmaher B, Wagner KD, Findling RL, Hellander M. Treatment guidelines for children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2005, 44:213-235. 10.1097/00004583-200503000-00006, 15725966.
47. Klein RG, Biederman J, Pine DS, Klein DF. Resolved: mania is mistaken for ADHD in prepubertal children: Negative. J Am Acad Child Adolesc Psychiatry 1998, 37:1093-1096.
48. Leibenluft E, Charney DS, Towbin KE, Bhangoo RK, Pine DS. Defining clinical phenotypes of juvenile mania. Am J Psychiatry 2003, 160:430-437. 10.1176/appi.ajp.160.3.430, 12611821.
49. Brotman MA, Schmajuk M, Rich BA, Dickstein DP, Guyer AE, Costello EJ, Egger HL, Angold A, Pine DS, Leibenluft E. Prevalence, clinical correlates, and longitudinal course of severe mood dysregulation in children. Biol Psychiatry 2006, 60:991-997. 10.1016/j.biopsych.2006.08.042, 17056393.
50. Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am J Psychiatry 1970, 126:983-987.
51. Brotman MA, Kassem L, Reising MM, Guyer AE, Dickstein DP, Rich BA, Towbin KE, Pine DS, McMahon FJ, Leibenluft E. Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry 2007, 164:1238-1241. 10.1176/appi.ajp.2007.06101619, 17671287.
52. Rich BA, Schmajuk M, Perez-Edgar KE, Fox NA, Pine DS, Leibenluft E. Different psychophysiological and behavioral responses elicited by frustration in pediatric bipolar disorder and severe mood dysregulation. Am J Psychiatry 2007, 164:309-317. 10.1176/appi.ajp.164.2.309, 17267795.
53. Brotman MA, Rich BA, Guyer AE, Lunsford JR, Horsey SE, Reising MM, Thomas LA, Fromm SJ, Towbin K, Pine DS, et al. Amygdala Activation During Emotion Processing of Neutral Faces in Children With Severe Mood Dysregulation Versus ADHD or Bipolar Disorder. Am J Psychiatry 2010, 167:61-69. 10.1176/appi.ajp.2009.09010043, 19917597.
54. American Psychiatric Association Disorders Usually First Diagnosed in Infancy, Childhood, or Adolescence 2010, American Psychiatric Association.
55. Wingo AP, Ghaemi SN. Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients. Psychopharmacol Bull 2008, 41:37-47.
56. Ghaemi SN, Wingo AP, Filkowski MA, Baldessarini RJ. Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks. Acta Psychiatr Scand 2008, 118:347-356. 10.1111/j.1600-0447.2008.01257.x, 2718794, 18727689.
57. McClellan J, Kowatch R, Findling RL. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2007, 46:107-125. 10.1097/CHI.0b013e3180691779, 17195735.
58. Carlson GA, Merry S. Bipolar Disorder in Children and Adolescents. Dulcan's Textbook of Child and Adolescent Psychiatry 2010, Washington DC: American Psychiatric Pub.
59. McClellan J, Werry J. Practice parameters for the assessment and treatment of children and adolescents with bipolar disorder. American Academy of Child and Adolescent Psychiatry. J Am Acad Child Adolesc Psychiatry 1997, 36:157S-176S. 10.1097/00004583-199707000-00018, 9432516.
60. U.S.Food and Drug Administration FDA Approves Risperdal for Two Psychiatric Conditions in Children and Adolescents. U S Food and Drug Administration website 2007, U.S.Food and Drug Administration.
61. Zito JM, Derivan AT, Kratochvil CJ, Safer DJ, Fegert JM, Greenhill LL. Off-label psychopharmacologic prescribing for children: history supports close clinical monitoring. Child and adolescent Psychiatry and Mental Health 2008, 2:24. 10.1186/1753-2000-2-24, 2566553, 18793403.
62. Safer DJ. Should selective serotonin reuptake inhibitors be prescribed for children with major depressive and anxiety disorders?. Pediatrics 2006, 118:1248-1251. 10.1542/peds.2006-0215, 16951019.
63. Bridge JA, Iyengar S, Salary CB, Barbe RP, Birmaher B, Pincus HA, Ren L, Brent DA. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA 2007, 297:1683. 10.1001/jama.297.15.1683, 17440145.
64. Goldstein BI, Birmaher B, Axelson DA, Goldstein TR, Esposito-Smythers C, Strober MA, Hunt J, Leonard H, Gill MK, Iyengar S, et al. Preliminary findings regarding overweight and obesity in pediatric bipolar disorder. J Clin Psychiatry 2008, 69:1953-1959. 10.4088/JCP.v69n1215, 19026266.
65. Correll C, Zuckerman IH. Second-generation antipsychotic-induced weight gain and metabolic abnormalities [abstract]. Abstracts of American Academy of Child and Adolescent Psychiatry 2003, 47.
66. Safer DJ. A comparison of risperidone-induced weight gain across the age span. J Clin Psychopharmacol 2004, 24:429-436. 10.1097/01.jcp.0000130558.86125.5b, 15232335.
67. Rasgon N. The relationship between polycystic ovary syndrome and antiepileptic drugs: a review of the evidence. J Clin Psychopharmacol 2004, 24:322-334. 10.1097/01.jcp.0000125745.60149.c6, 15118487.
68. Jiang B, Kenna HA, Rasgon NL. Genetic overlap between polycystic ovary syndrome and bipolar disorder: The endophenotype hypothesis. Med Hypotheses 2009,
69. Choonara I, Conroy S. Unlicensed and off-label drug use in children: implication for safety. Drug Safety 2002, 25:1-5. 10.2165/00002018-200225010-00001, 11820908.
70. Crystal S, Olfson M, Huang C, Pincus H, Gerhard T. Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges. Health Aff (Millwood) 2009, 28:w770-w781. 10.1377/hlthaff.28.5.w770, 19622537.
71. Marchand WR, Wirth L, Simon C. Adverse life events and pediatric bipolar disorder in a community mental health setting. Community Ment Health J 2005, 41:67-75. 10.1007/s10597-005-2600-x, 15932053.
72. Zito JM, Safer DJ, dosReis S, Gardner JF, Magder L, Soeken K, Boles M, Lynch F, Riddle MA. Psychotropic practice patterns for youth: a 10-year perspective. Arch Pediatr Adolesc Med 2003, 157:17-25.
73. Zito JM, Safer DJ, Gardner JF, Soeken K, Ryu J. Anticonvulsant treatment for psychiatric and seizure indication among youths. Psychiatr Serv 2006, 57:681-685. 10.1176/appi.ps.57.5.681, 16675763.
74. Zito JM, Hundley SD, Safer DJ. National trends in the ambulatory treatment of youth with anticonvulsant-mood stabilizers for psychiatric disorders (Poster). 2008 American Academy of Child and Adolescent Psychiatry 2008,
75. Zito JM. Pharmacoepidemiology: recent findings and challenges for child and adolescent psychopharmacology. J Clin Psychiatry 2007, 68:966-967. 10.4088/JCP.v68n0622, 17592925.
76. APHA Joint Policy Committee Regulating Drugs for Effectiveness and Safety: A Public Health Perspective: Position Paper 2006, APHA Joint Policy Committee.
77. Goodwin FK, Jamison KR. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression 2007, New York: Oxford University Press.
78. Miklowitz DJ, Goldstein MJ. Bipolar Disorder: A Family-Focused Treatment Approach 1997, New York: Guilford Publications.
79. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Wisniewski SR, Kogan JN, Nierenberg AA, Calabrese JR, Marangell LB, Gyulai L, et al. Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry 2007, 64:419-426. 10.1001/archpsyc.64.4.419, 17404119.
80. Miklowitz DJ, George EL, Axelson DA, Kim EY, Birmaher B, Schneck C, Beresford C, Craighead WE, Brent DA. Family-focused treatment for adolescents with bipolar disorder. J Affect Disord 2004, 82(Suppl 1):S113-S128. 10.1016/j.jad.2004.05.020, 2754177, 15571785.
81. Miklowitz DJ, Axelson DA, Birmaher B, George EL, Taylor DO, Schneck CD, Beresford CA, Dickinson LM, Craighead WE, Brent DA. Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial. Arch Gen Psychiatry 2008, 65:1053-1061. 10.1001/archpsyc.65.9.1053, 2610285, 18762591.
82. Feeny NC, Danielson CK, Schwartz L, Youngstrom EA, Findling RL. Cognitive-behavioral therapy for bipolar disorders in adolescents: a pilot study. Bipolar Disord 2006, 8:508-515. 10.1111/j.1399-5618.2006.00358.x, 17042890.
83. Pavuluri MN, Graczyk PA, Henry DB, Carbray JA, Heidenreich J, Miklowitz DJ. Child- and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary results. J Am Acad Child Adolesc Psychiatry 2004, 43:528-537. 10.1097/00004583-200405000-00006, 15100559.
84. Fristad MA, Gavazzi SM, Mackinaw-Koons B. Family psychoeducation: an adjunctive intervention for children with bipolar disorder. Biol Psychiatry 2003, 53:1000-1008. 10.1016/S0006-3223(03)00186-0, 12788245.
85. Ibe A, Zito J, Safer D, Magder L, Bronner Y, Valluri S. Impact of New-Onset Pediatric Bipolar Disorder among Medicaid-insured Youth. 2009 American Psychiatric Association Annual Meeting 2009,