Electroporation-mediated delivery of a naked DNA plasmid expressing VEGF to the porcine heart enhances protein expression

Gene Therapy

Volumn 17, Issue 3, 2010, Pages 419-423

  Marshall, W G ^a   Boone, B A ^a   Burgos, J D ^a   Gografe, S I ^b,d   Baldwin, M K ^b   Danielson, M L ^b   Larson, M J ^b   Caretto, D R ^b   Cruz, Y ^a   Ferraro, B ^a   Heller, L C ^a,e   Ugen, K E ^a   Jaroszeski, M J ^c   Heller, R ^a,e  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c University of South Florida   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e OLD DOMINION UNIVERSITY   (United States)

Author keywords

Cardiovascular; Electroporation; Heart; Nonviral; VEGF

Indexed keywords

FIREFLY LUCIFERASE; NAKED DNA; PLASMID DNA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

ANIMALS; CORONARY ARTERY DISEASE; DNA; ELECTROPORATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART; PLASMIDS; PROTEIN BIOSYNTHESIS; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA; SUS;

EID: 77949423992     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2009.153     Document Type: Article

References (34)

1. Mukherjee D, Bhatt DL, Roe MT, Patel V, Ellis SG. Direct myocardial revascularization and angiogenesis\how many patients might be eligible? Am J Cardiol 1999; 84: 598-600; A598.
2. Brewster L, Brey EM, Greisler HP. Cardiovascular gene delivery: the good road is awaiting. Adv Drug Deliv Rev 2006; 58: 604-629.
3. Fortuin FD, Vale P, Losordo DW, Symes J, DeLaria GA, Tyner JJ et al. One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients. Am J Cardiol 2003; 92: 436-439.
4. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD et al. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation 2002; 105: 1291-1297.
5. Sarkar N, Ruck A, Kallner G, Y-Hassan S, Blomberg P, Islam KB et al. Effects of intramyocardial injection of phVEGF-A165 as sole therapy in patients with refractory coronary artery disease-12-month follow-up: angiogenic gene therapy. J Intern Med 2001; 250: 373-381.
6. Stewart DJ, Hilton JD, Arnold JM, Gregoire J, Rivard A, Archer SL et al. Angiogenic gene therapy in patients with nonrevascu-larizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment. Gene Therapy 2006; 13: 1503-1511.
7. Dean DA. Nonviral gene transfer to skeletal, smooth, and cardiac muscle in living animals. Am J Physiol Cell Physiol 2005; 289: C233-C245.
8. Schalch P, Rahman GF, Patejunas G, Goldschmidt RA, Carbray J, Retuerto MA et al. Adenoviral-mediated transfer of vascular endothelial growth factor 121 cDNA enhances myocardial perfusion and exercise performance in the nonischemic state. J Thorac Cardiovasc Surg 2004; 127: 535-540.
9. Herweijer H, Wolff JA. Progress and prospects: naked DNA gene transfer and therapy. Gene Therapy 2003; 10: 453-458.
10. Niidome T, Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Therapy 2002; 9: 1647-1652.
11. Nishikawa M, Huang L. Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 2001; 12: 861-870.
12. Wells DJ. Gene therapy progress and prospects: electropora-tion and other physical methods. Gene Therapy 2004; 11: 1363-1369.
13. Caplen NJ, Alton EW, Middleton PG, Dorin JR, Stevenson BJ, Gao X et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med 1995; 1: 39-46.
14. Felgner PL, Gadek TR, Holm M, Roman R, Chan HW, Wenz M et al. Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987; 84: 7413-7417.
15. Nicolau C, Sene C. Liposome-mediated DNA transfer in eukaryotic cells. Dependence of the transfer efficiency upon the type of liposomes used and the host cell cycle stage. Biochim Biophys Acta 1982; 721: 185-190.
16. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 1993; 90: 11478-11482.
17. Sun WH, Burkholder JK, Sun J, Culp J, Turner J, Lu XG et al. In vivo cytokine gene transfer by gene gun reduces tumor growth in mice. Proc Natl Acad Sci USA 1995; 92: 2889-2893.
18. Yang NS, Burkholder J, Roberts B, Martinell B, McCabe D. In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 1990; 87: 9568-9572.
19. Liu D, Knapp JE. Hydrodynamics-based gene delivery. Curr Opin Mol Ther 2001; 3: 192-197.
20. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Therapy 1999; 6: 1258-1266.
21. Mir LM. Therapeutic perspectives of in vivo cell electropermea- bilization. Bioelectrochemistry (Amsterdam, The Netherlands) 2001; 53: 1-10.
22. Aihara H, Miyazaki J. Gene transfer into muscle by electropora-tion in vivo. Nat Biotechnol 1998; 16: 867-870.
23. Glasspool-Malone J, Somiari S, Drabick JJ, Malone RW. Efficient nonviral cutaneous transfection. Mol Ther 2000; 2: 140-146.
24. Heller LC, Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 2006; 17: 890-897.
25. Lucas ML, Heller R. Immunomodulation by electrically enhanced delivery of plasmid DNA encoding IL-12 to murine skeletal muscle. Mol Ther 2001; 3: 47-53.
26. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK et al. Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma. J Clin Oncol 2008; 26: 5896-5903.
27. Low L, Mander A, McCann KJ, Dearnaley D, Tjelle TE, Mathiesen I et al. DNA vaccination with electroporation induces increased antibody responses in patients with prostate cancer. Hum Gene Ther 2009; 20: 1269-1278.
28. Harrison RL, Byrne BJ, Tung L. Electroporation-mediated gene transfer in cardiac tissue. FEBS Lett 1998; 435: 1-5.
29. Thompson JF, Hayes LS, Lloyd DB. Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene 1991; 103: 171-177.
30. Takeshita S, Zheng LP, Brogi E, Kearney M, Pu L-Q, Bunting S et al. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest 1994; 93: 662-670.
31. Lazarous DF, Shou M, Scheinowitz M, Hodge E, Thirumurti V, Kitsiou A et al. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Circulation 1996; 94: 1074-1082.
32. Hojman P, Gissel H, Andre FM, Cournil-Henrionnet C, Eriksen J, Gehl J et al. Physiological effects of high and low voltage pulse combinations for gene electrotransfer in muscle. Hum Gene Ther 2008; 19: 1249-1260.
33. Kastrup J, Jørgensen E, Rück A, Tägil K, Glogar D, Ruzyllo W et al. Direct intramyocardial plasmid vascular endothelial growth factor-a165 gene therapy in patients with stable severe angina pectoris. J Am Coll Cardiol 2005; 45: 982-988.
34. Gaffney MM, Hynes SO, Barry F, O'Brien T. Cardiovascular gene therapy: current status and therapeutic potential. Br J Pharmacol 2007; 152: 175-188.