Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: In vivo and in vitro study and implications to secondary neoplasia

Leukemia

Volumn 24, Issue 3, 2010, Pages 536-543

  Themeli, M ^a   Petrikkos, L ^b   Waterhouse, M ^b   Bertz, H ^b   Lagadinou, E ^a   Zoumbos, N ^a   Finke, J ^b   Spyridonidis, A ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Allogeneic hematopoietic cell transplantation; Graft vs host disease; Microsatellite instability

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; CD34 ANTIGEN; DNA; METHOTREXATE; REACTIVE OXYGEN METABOLITE; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG MEGADOSE; FEMALE; FRAMESHIFT MUTATION; GENETIC RISK; GENOMIC INSTABILITY; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MIXED LYMPHOCYTE CULTURE; MUTATIONAL ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SECOND CANCER; T LYMPHOCYTE; WHOLE BODY RADIATION;

EID: 77949423315     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.284     Document Type: Article

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