Functional dissociation of the frontoinsular and anterior cingulate cortices in empathy for pain

Journal of Neuroscience

Volumn 30, Issue 10, 2010, Pages 3739-3744

  Gu, Xiaosi ^a   Liu, Xun ^a   Guise, Kevin G ^a   Naidich, Thomas P ^a   Hof, Patrick R ^a   Fan, Jin ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BEHAVIOR; BODY REGIONS; CINGULATE GYRUS; CONTROLLED STUDY; DISSOCIATION; EMPATHY; FEMALE; FRONTAL CORTEX; FRONTOINSULAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMISPHERIC DOMINANCE; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; MALE; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PHOTOGRAPHY; PRIORITY JOURNAL; REACTION TIME; TASK PERFORMANCE;

ADULT; BRAIN MAPPING; CEREBRAL CORTEX; EMPATHY; FEMALE; FRONTAL LOBE; GYRUS CINGULI; HUMANS; MALE; PAIN; PAIN MEASUREMENT; PHOTIC STIMULATION; PILOT PROJECTS; YOUNG ADULT;

EID: 77949404388     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4844-09.2010     Document Type: Article

References (37)

1. Akitsuki Y, Decety J (2009) Social context and perceived agency affects empathy for pain: an event-related fMRI investigation. Neuroimage 47: 722-734.
2. Blakemore SJ (2008) The social brain in adolescence. Nat Rev Neurosci 9:267-277.
3. Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL (2003) Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A 100:5497-5502.
4. Cohen RA, Kaplan RF, Zuffante P, Moser DJ, Jenkins MA, Salloway S, Wilkinson H (1999) Alteration of intention and self-initiated action associated with bilateral anterior cingulotomy. J Neuropsychiatry Clin Neurosci 11:444-453.
5. Cohen RA, Paul R, Zawacki TM, Moser DJ, Sweet L, Wilkinson H (2001) Emotional and personality changes following cingulotomy. Emotion 1:38-50.
6. Craig AD (2009) How do you feel-now? The anterior insula and human awareness. Nat Rev Neurosci 10:59-70.
7. Craig AD, Chen K, Bandy D, Reiman EM (2000) Thermosensory activation of insular cortex. Nat Neurosci 3:184-190.
8. Critchley HD (2004) The human cortex responds to an interoceptive challenge. Proc Natl Acad Sci U S A 101:6333-6334.
9. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ (2004) Neural systems supporting interoceptive awareness. Nat Neurosci 7:189-195.
10. Davis KD, Hutchison WD, Lozano AM, Dostrovsky JO (1994) Altered pain and temperature perception following cingulotomy and capsulotomy in a patient with schizoaffective disorder. Pain 59:189-199.
11. Decety J, Chaminade T (2003) Neural correlates of feeling sympathy. Neuropsychologia 41:127-138.
12. de Vignemont F, Singer T (2006) The empathic brain: how, when and why? Trends Cogn Sci 10:435- 441.
13. Eckert MA, Menon V, Walczak A, Ahlstrom J, Denslow S, Horwitz A, Dubno JR (2009) At the heart of the ventral attention system: the right anterior insula. Hum Brain Mapp 30:2530-2541.
14. Fan J, Hof PR, Guise KG, Fossella JA, Posner MI (2008) The functional integration of the anterior cingulate cortex during conflict processing. Cereb Cortex 18:796-805.
15. Friston KJ, Frith CD, Turner R, Frackowiak RSJ (1995) Characterizing evoked hemodynamics with fMRI. Neuroimage 2:157-165.
16. Friston KJ, Fletcher P, Josephs O, Holmes A, Rugg MD, Turner R (1998) Event-related fMRI: characterizing differential responses. Neuroimage 7:30-40.
17. Gallagher HL, Happé F, Brunswick N, Fletcher PC, Frith U, Frith CD (2000) Reading the mind in cartoons and stories: an fMRI study of "theory of mind" in verbal and nonverbal tasks. Neuropsychologia 38:11-21.
18. Genovese CR, Lazar NA, Nichols T (2002) Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15:870-878.
19. Gu X, Han S (2007) Attention and reality constraints on the neural processes of empathy for pain. Neuroimage 36:256-267.
20. Hahn B, Ross TJ, Stein EA (2007) Cingulate activation increases dynamically with response speed under stimulus unpredictability. Cereb Cortex 17:1664-1671.
21. Jabbi M, Swart M, Keysers C (2007) Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 34:1744-1753.
22. Jackson PL, Meltzoff AN, Decety J (2005) How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage 24:771-779.
23. Kennerley SW, Walton ME, Behrens TE, Buckley MJ, Rushworth MF (2006) Optimal decision making and the anterior cingulate cortex. Nat Neurosci 9:940-947.
24. Lamm C, Batson CD, Decety J (2007) The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal. J Cogn Neurosci 19:42-58.
25. Naito E, Kinomura S, Geyer S, Kawashima R, Roland PE, Zilles K (2000) Fast reaction to different sensory modalities activates common fields in the motor areas, but the anterior cingulate cortex is involved in the speed of reaction. J Neurophysiol 83:1701-1709.
26. Peyron R, Laurent B, García-Larrea L (2000) Functional imaging of brain responses to pain: a review and meta-analysis. Neurophysiol Clin 30:263-288.
27. Preston SD, de Waal FB (2002) Empathy: its ultimate and proximate bases. Behav Brain Sci 25:1-20; discussion 20-71.
28. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968-971.
29. Ruby P, Decety J (2004) How would you feel versus how do you think she would feel? A neuroimaging study of perspective-taking with social emotions. J Cogn Neurosci 16:988-999.
30. Rudebeck PH, Buckley MJ, Walton ME, Rushworth MF (2006) A role for the macaque anterior cingulate gyrus in social valuation. Science 313:1310-1312.
31. Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27:2349-2356.
32. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303:1157-1162.
33. Singer T, Critchley HD, Preuschoff K (2009) A common role of insula in feelings, empathy and uncertainty. Trends Cogn Sci 13:334-340.
34. Sridharan D, Levitin DJ, Menon V (2008) A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc Natl Acad Sci U S A 105:12569-12574.
35. Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psych 18:643-662.
36. Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, Kosslyn SM, Rose RM, Cohen JD (2004) Placebo-induced changes in fMRI in the anticipation and experience of pain. Science 303:1162-1167.
37. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G (2003) Both of us disgusted in My insula: the common neural basis of seeing and feeling disgust. Neuron 40:655-664.