Are conundrums with uncertainty factors an obstacle to developing probabilistic interpretations of noncancer risks from Chemicals?: Commentary

Risk Analysis

Volumn 30, Issue 3, 2010, Pages 340-345

  Goble, Rob ^a   Hattis, Dale ^a  

^a CLARK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; NOTE; RISK; UNCERTAINTY;

HUMANS; RISK; UNCERTAINTY;

EID: 77949402365     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2010.01364.x     Document Type: Note

References (12)

1. Cooke R. Conundrums with uncertainty factors. Risk Analysis, 2010 30 (3 330 339.
2. Lehman AJ, Fitzhugh OG. 100-fold margin of safety. Association of Food & Drug Office. U.S. Q. Bull., 1954 18 : 33 35.
3. US EPA. IRIS Data Base http//www.epa.gov/IRIS/, frequently updated.
4. Hattis D, Baird S, Goble R. A Straw Man Proposal for a Quantitative Definition of the RfD, in Final Technical Report, U.S. Environmental Protection Agency STAR grant R825360, Human Variability in Parameters Potentially Related to Susceptibility for Noncancer Risks. Full version available at http://www2.clarku.edu/faculty/dhattis shortened version in Drug and Chemical Toxicology 2002 25 : 403 436.
5. Hattis D, Lynch MK. Empirically observed distributions of pharmacokinetic and pharmacodynamic variability in humans - Implications for the derivation of single point component uncertainty factors providing equivalent protection as existing RfDs. Pp. 69 93 in Lipscomb JC, Ohanian EV (eds). Toxicokinetics in Risk Assessment. Informa Healthcare USA, Inc., 2007.
6. National Research Council. Science and Decisions: Improving Risk Analysis, National Research Council Committee on Improving Risk Analysis Approaches Used by the U.S. EPA. Washington, DC : National Academy of Sciences Press, 2009.
7. National Research Council. Science and Judgment in Risk Assessment. Washington, DC : National Academy Press, 1994.
8. Crump KS, Hoel DG, Langley CH, Peto R. Fundamental carcinogenic processes and their implications for low dose risk assessment. Cancer Research, 1976 36 : 2973 2979.
9. Hattis D, Goble R. Uncertainties in Risk Assessment for Carcinogenesis: A Road Map Toward Practical Improvements, White Paper, Clark University, May 2007.
10. Hattis D, Goble R. The Pantoxin Project, Concept Paper, Clark University, updated November 2007.
11. Price PS, Keenan RE, Swartout JC. Characterizing interspecies uncertainty using data from studies of anti-neoplastic agents in animals and humans. Toxicology and Applied Pharmacology, 2008 233 (1 64 70.
12. Hattis D, Lynch MK. Alternatives to Pollutant-by-Pollutant Dose-Response Estimation for Air Toxics, report/conference paper by Abt Associates, Inc. to the U.S. Environmental Protection Agency under EP-W-05-022 WA 3-80, Draft, July 2009.