Effect of antimicrobial agents on the toll-like receptors and inflammatory cytokines in liver tissue of the alcohol-induced liver disease in rats with Vibrio vulnificus sepsis

Chinese Medical Journal

Volumn 122, Issue 16, 2009, Pages 1910-1916

  Lu, Zhong Qiu ^a   Li, Meng Fang ^a   Qiu, Qiao Meng ^a   Liang, Huang ^a   Zhou, Tie Li ^a   Hong, Guang Liang ^a   Wu, Bin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cefoperazone sodium; Inflammatory cytokines; Levofloxacin; Sepsis; Toll like receptors; Vibrio vulnificus

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; BIOLOGICAL FACTOR; CEFOPERAZONE; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEVOFLOXACIN; MESSENGER RNA; MYELOID DIFFERENTIATION PROTEIN 2; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL THERAPY; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; GENE EXPRESSION REGULATION; LIVER LEVEL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; UPREGULATION; VIBRIO VULNIFICUS INFECTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTI-INFECTIVE AGENTS; CYTOKINES; INTERLEUKIN-10; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEPSIS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA; VIBRIO INFECTIONS; VIBRIO VULNIFICUS;

EID: 70349534328     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.16.014     Document Type: Article

References (20)

1. Miyake K. Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2. Int Immunopharmacol 2003; 3: 119.
2. Tetsuya M, Tipayaratn M, Tomohiko O, Yasunobu Y. Gene expression of toll-like receptor 2, but not toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophag. J Immunol 2000; 165: 5767-5772.
3. Matsuquchi T, Takaqi K, Musikacharoen T, Yoshikai Y. Gene expression of lipopolysccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes. Blood 2000; 95: 1378-1385.
4. Zhou RB, Lu ZQ, Li TS. Discussion on Neural-endocrine-Immune Network mechanism and significance of sepsis. Int J Emerg Crit Care Med 2007; 4: 1894-1896.
5. Kim J S. Cytotoxicity of Vibrio vulnificus cytolysin on pulmonary endothelial cells. Exp Mol Med 1997; 29: 117-121.
6. Miyoshi S, Nakazawa H, Kawata K, Tomochika K, Tobe K, Shinoda S. Characterization of the hemorrhagic reaction caused by Vibrio vulnificus metalloprotease, a member of the thermolysin family. Infect Immun 1998; 66: 4851-4855.
7. Shapiro RL, Altekruse S, Hutwagner L, Bishop R, Hammond R, Wilson S, et al. The role of Gulf Coast oysters harvested in warmer months in Vibrio vulnificus infections in the United States, 1988-1996. Vibrio Working Group. J Infect Dis 1998; 178: 752-759.
8. Hong GL, Lu ZQ. The research status of chronic liver disease patients with Vibrio vulnificus sepsis. Chin J Microecol (Chin) 2007; 19: 236-237.
9. Zhou CH, Lu ZQ, Li HP, Wu B, Li JR, Hu GX. The animal model rats alcohol liver disease. Zhejiang Clin Med J (Chin) 2007; 9: 435-436.
10. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000; 406: 782-787.
11. Dauphinee SM, Karsan A. Lipopolysaccharide signaling in endothelial cells. Lab Invest 2006; 86: 9-22.
12. Lu ZQ, Liang H, Li JR, Qiu QM, Zhang SH, Zhou TL, et al. The expression and the dynamic change of lipopolysaccharide receptor mCD14 in peripheral blood of the rats with Vibrio vulnificus sepsis. Chin J Emerg Resusci Disaster Med (Chin) 2006; 1: 152-155.
13. Su GL, Klein RD, Aminlari A, Zhang HY, Steinstraesser L, Alarcon WH, et al. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysacccharide binding protein and toll-likereceptor 4. Hepatology 2000; 31: 932-936.
14. Yang H, Young DW, Gusovsky F, Chow JC. Cellular events mediated by Lipopolysaccharide stimulated toll-like receptor 4 MD-2 is required for Activation of mitogen activated protein kinases and Elk-1. J Bio Chem 2000; 275: 20861-20866.
15. Miyake K. Endotoxin recognition molecules, Toll-like receptor 4-MD-2. Semin Immunol 2004; 16: 11-16.
16. LU ZQ, QIU QM, LI HY, Liang H, Hu GX, Wang MS, et al. The histopathology and serum cytokine changes in Vibrio vulnificus sepsis of rats. Zhejiang Med J (Chin) 2007; 29: 23-25.
17. Zhang DL, Zheng HM, Yu BJ, Jiang ZW, Li JS. Association of polymorphisms of IL and CD14 genes with acute severe pancreatitis and septic shock. World J Gastroenterol 2005; 11: 4409-4413.
18. Lu ZQ, Liang H, Li JR, Qiu QM, Zhou TL, Zhang SH, et al. Effects of antibacterialagents on the expression of lipopolysaccharide receptor mCD14 in peripheral blood of the rats with Vibrio vulnificus sepsis. Chin J Crit Care Med (Chin), 2006; 26: 602-604.
19. Lu ZQ, Qiu QM, Li JR, Lu CJ, Cheng JY, Zhou TL. Early clinical diagnosis and treatment of vibrio pyemia. Chin J Crit Care Med (Chin) 2004, 24: 652-654.
20. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999; 274: 10689-10692.