Cutaneous xanthogranulomas, hepatosplenomegaly, anemia, and thrombocytopenia as presenting signs of juvenile myelomonocytic leukemia

American Journal of Clinical Dermatology

Volumn 11, Issue 1, 2010, Pages 67-71

  Cham, Elaine ^a   Siegel, Dawn ^b   Ruben, Beth S ^b  

^a Evanston Northwestern Healthcare ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; METHYLPREDNISOLONE;

ABDOMINAL RADIOGRAPHY; ANEMIA; ARTICLE; BONE MARROW BIOPSY; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; GRAFT VERSUS HOST REACTION; HEMOGLOBIN BLOOD LEVEL; HEPATOSPLENOMEGALY; HISTOPATHOLOGY; HUMAN; INFANT; JUVENILE MYELOMONOCYTIC LEUKEMIA; JUVENILE XANTHOGRANULOMA; LEUKOCYTE COUNT; LYMPHADENOPATHY; MALE; MONOCYTOSIS; NEUROFIBROMATOSIS; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PUNCH BIOPSY; SKIN BIOPSY; STEM CELL TRANSPLANTATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

6-MERCAPTOPURINE; ANEMIA; ANTIMETABOLITES; HEPATOMEGALY; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; SPLENOMEGALY; STEM CELL TRANSPLANTATION; THROMBOCYTOPENIA; TREATMENT OUTCOME; XANTHOGRANULOMA, JUVENILE;

EID: 77949382562     PISSN: 11750561     EISSN: 11791888     Source Type: Journal    
DOI: 10.2165/11311130-000000000-00000     Document Type: Article

References (19)

1. Cooper PH, Frierson HF, Kayne AL, et al. Association of juvenile xanthogranu-loma with juvenile myeloid leukemia. Arch Dermatol 1984 Mar; 120 (3): 371-375
2. Shin HT, Harris MB, Orlow SJ. Juvenile myelomonocytic leukemia presenting with features of hemophagocytic lymphohistiocytosis in association with neurofibromatosis and juvenile xanthogranulomas. J Pediatr Hematol Oncol 2004 Sep; 26 (9): 591-595
3. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibro-matosis, and juvenile chronic myelogenous leukemia: world statistical analysis. Arch Dermatol 1995 Aug; 131 (8): 904-908
4. Dehner LP. Juvenile xanthogranuloma in the first two decades of life. Am J Surg Path 2003; 27 (5): 579-593
5. JanssenD, Harms D. Juvenile xanthogranuloma in childhood and adolescence. Am J Surg Path 2005; 29 (1): 21-28
6. Hara T, Ohga S, Hattori S, et al. Prolonged severe pancytopenia preceding the cuta-neous lesions of juvenile xanthogranuloma. Pediatr Blood Cancer 2006; 47: 103-106
7. Hasle H, Niemeyer CM, Chessells JM, et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative disorders. Leukemia 2003; 17: 277-282
8. Murphy GF, Schwarting R. Cutaneous lymphomas and leukemias. In: Elder DE, editor. Lever's histopathology of the skin. Philadelphic (PA): Lippincott Williams and Wilkins, 2005: 927-978
9. Sires UI, Mallory SB, Hess JL, etal. Cutaneous presentation of juvenile chronic myelogenous leukemia: a diagnostic and therapeutic dilemma. Pediatr Der-matol 1995; 12: 364-368
10. Vardiman JW, Pierre R, Imbert M, et al. Juvenile myelomonocytic leukemia. In: Jaffe ES, Harris NL, Stein H, et al., editors. World Health Organization classification of tumors: pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2001: 55-57
11. Side L, Taylor B, Cayouette M, et al. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med 1997; 336 (24): 1713-1722
12. Luna-Fineman S, Shannon KM, Atwater SK, et al. Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients. Blood 1999; 93: 459-466
13. Stiller CA, Chessels JM, Fitchett M. Neurofibromatosis and childhood leukemia/ lymphoma: a population-based UKCCSG study. Br J Cancer 1994; 70: 969-972
14. Schubbert S, Lieuw K, Rowe SL, et al. Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells. Blood 2005 Jan; 106 (1): 311-317
15. Bentires-Alj M, Paez JG, David FS, et al. Activating mutations of the Noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res 2004 Dec 15; (64): 8816-8820
16. Stockman A, Delanghe J, Geerts ML, et al. Diffuse plane normolipaemic xanthomatosis in a patient with chronic lymphocytic leukemia and monoclonal gammopathy. Dermatology 2002; 204 (4): 351-354
17. Kourou K, Suga Y, Muramatsu S, et al. A case of diffuse plane normolipemic xanthomatosis associated with pancytopenia and monoclonal gammopathy. J Dermatol 2006 Jan; 33 (1): 64-67
18. Oumeish OY, Oumeish I, Tarawneh M, et al. Necrobiotic xanthogranuloma associated with paraproteinemia and non-Hodgkin lymphoma developing into chronic lymphocytic leukemia: the first case reported in the literature and review of the literature. Int J Dermatol 2006; 45: 306-310
19. Larson MJ, Bandel C, Eichhorn PJ, et al. Concurrent development of eruptive xanthogranulomas and hematologic malignancy: two case reports. J Am Acad Dermatol 2004 Jun; 50 (6): 976-978