Mimotope vaccination for therapy of allergic asthma: Anti-inflammatory effects in a mouse model

Clinical and Experimental Allergy

Volumn 40, Issue 4, 2010, Pages 650-658

  Wallmann, J ^a   Epstein, M M ^b   Singh, P ^b   Brunner, R ^a   Szalai, K ^a   El Housseiny, L ^b   Pali Scholl I ^a   Jensen Jarolim, E ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

Author keywords

Epitope specific immunotherapy; Grass pollen allergy; Mimotopes

Indexed keywords

ALLERGEN; CYTOKINE; EPITOPE; HEMOCYANIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; MIMOTOPE VACCINE; PEPTIDE VACCINE; POLLEN ANTIGEN; RECOMBINANT ALLERGEN; RECOMBINANT ALLERGEN PH1 P 5A; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; CELL HYPERPLASIA; CELL PROLIFERATION; CYTOKINE PRODUCTION; EXPERIMENTAL MODEL; GOBLET CELL; GRASS POLLEN; HYPEREOSINOPHILIA; IN VITRO STUDY; INFLAMMATION; LUNG LAVAGE; MOUSE; MUCUS; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TH2 CELL; VACCINATION;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNOGLOBULIN E; INFLAMMATION; MICE; MICE, INBRED BALB C; MOLECULAR MIMICRY; PLANT PROTEINS; RECOMBINANT PROTEINS; RESPIRATORY HYPERSENSITIVITY; TREATMENT OUTCOME; VACCINATION;

EID: 77949372068     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03392.x     Document Type: Article

References (21)

1. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006; 6:761-71.
2. Akdis M. Healthy immune response to allergens: T regulatory cells and more. Curr Opin Immunol 2006; 18:738-44.
3. Jutel M, Akdis M, Budak F et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205-14.
4. Ali FR, Oldfield WL, Higashi N, Larche M, Kay AB. Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides. Am J Respir Crit Care Med 2004; 169:20-6.
5. Smith TR, Larche M. Investigating T cell activation and tolerance in vivo: peptide challenge in allergic asthmatics. Cytokine 2004; 28:49-54.
6. Wallmann J, Proell M, Stepanoska T et al. A mimotope gene encoding the major IgE epitope of allergen Phl p 5 for epitopespecific immunization. Immunol Lett 2009; 122:68-75.
7. Scholl I, Wiedermann U, Forster-Waldl E et al. Phage-displayed Bet mim 1, a mimotope of the major birch pollen allergen Bet v 1, induces B cell responses to the natural antigen using bystander T cell help. Clin Exp Allergy 2002; 32:1583-8.
8. Hantusch B, Krieger S, Untersmayr E et al. Mapping of conformational IgE epitopes on Phl p 5a by using mimotopes from a phage display library. J Allergy Clin Immunol 2004; 114:1294-300.
9. Hantusch B, Knittelfelder R, Wallmann J et al. Internal images: human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a. Mol Immunol 2006; 43:2180-7.
10. Mojtabavi N, Dekan G, Stingl G, Epstein MM. Long-lived Th2 memory in experimental allergic asthma. J Immunol 2002; 169:4788-96.
11. Waldegrave W. Directive CEE 86/609. J Officiel Communautés 1986; L358:1-28.
12. Leitner A, Vogel M, Radauer C et al. A mimotope defined by phage display inhibits IgE binding to the plant panallergen profilin. Eur J Immunol 1998; 28:2921-7.
13. Paseyro P, Varela Lopez M, Prodanov E, Villar H, Ghiggino CW. Simple technic for the cytologic study of sputum using the May Grunwald-Giemsa stain. Med Panam 1957; 9:63-6.
14. Luna L. Manual of histologic staining methods of the armed forces. Institute of Pathology, New York, 1968; 114-5.
15. EpsteinMM. Are mouse models of allergic asthma useful for testing novel therapeutics? Exp Toxicol Pathol 2006; 57 (Suppl. 2):41-4.
16. Ford JG, Rennick D, Donaldson DD et al. Il-13 and IFN-gamma: interactions in lung inflammation. J Immunol 2001; 167:1769-77.
17. Foster PS, Ming Y, Matthei KI et al. Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma. Lab Invest 2000; 80:655-62.
18. Rosenberg HF, Phipps S, Foster PS. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol 2007; 119:1303-10; quiz 1311-2.
19. McHeyzer-Williams MG, Ahmed R. B cell memory and the longlived plasma cell. Curr Opin Immunol 1999; 11:172-9.
20. Jensen-Jarolim E, Achatz G, TurnerMC et al. AllergoOncology: the role of IgE-mediated allergy in cancer. Allergy 2008; 63:1255-66.
21. Cohn L. Mucus in chronic airway diseases: sorting out the sticky details. J Clin Invest 2006; 116:306-8.