Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD

Journal of the American Society of Nephrology

Volumn 21, Issue 2, 2010, Pages 261-271

  Douard, Veronique ^a   Asgerally, Abbas ^a   Sabbagh, Yves ^b   Sugiura, Shozo ^c   Shapses, Sue A ^d   Casirola, Donatella ^a   Ferraris, Ronaldo P ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b GENZYME CORPORATION   (United States)

^c UNIVERSITY OF SHIGA PREFECTURE   (Japan)

^d RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALBINDIN; CALCIFEDIOL; CALCITRIOL; CALCIUM; CREATININE; FRUCTOSE; GLUCOSE; NITROGEN; OXYGENASE; PHOSPHATE; PHOSPHATE TRANSPORTER; UREA; CALCIDIOL 1 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM TRANSPORT; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIETARY INTAKE; DOWN REGULATION; HISTOLOGY; HYPERPHOSPHATEMIA; INTESTINE ABSORPTION; KIDNEY MASS; MALE; NEPHRECTOMY; NONHUMAN; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; UREA NITROGEN BLOOD LEVEL; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; ANIMAL; BONE DENSITY; CARBOHYDRATE DIET; CHRONIC DISEASE; DISEASE MODEL; DRUG EFFECT; KIDNEY; KIDNEY DISEASE; METABOLISM; SPRAGUE DAWLEY RAT;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BONE DENSITY; CALCIFEDIOL; CALCITRIOL; CALCIUM; CHRONIC DISEASE; DIETARY CARBOHYDRATES; DISEASE MODELS, ANIMAL; FRUCTOSE; GLUCOSE; INTESTINAL ABSORPTION; KIDNEY; KIDNEY DISEASES; MALE; NEPHRECTOMY; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN D DEFICIENCY;

EID: 77949367895     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2009080795     Document Type: Article

References (49)

1. Gilbertson DT, Liu J, Xue JL, Louis TA, Solid CA, Ebben JP, Collins AJ: Projecting the number of patients with end-stage renal disease in the United States to the year 2015. J Am Soc Nephrol 16: 3736-3741, 2005
2. Luk AO, So WY, Ma RC, Kong AP, Ozaki R, Ng VS, Yu LW, Lau WW, Yang X, Chow FC, Chan JC, Tong PC: Metabolic syndrome predicts new onset of chronic kidney disease in 5,829 patients with type 2 diabetes: A 5-year prospective analysis of the Hong Kong Diabetes Registry. Diabetes Care 31: 2357-2361, 2008
3. Lea J, Cheek D, Thornley-Brown D, Appel L, Agodoa L, Contreras G, Gassman J, Lash J, Miller ER 3rd, Randall O, Wang X, McClellan W: Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African Americans. Am J Kidney Dis 51: 732-740, 2008
4. Le KA, Tappy L: Metabolic effects of fructose. Curr Opin Clin Nutr Metab Care 9: 469-475, 2006
5. Havel PJ: Dietary fructose: Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63: 133-157, 2005
6. Higashiura K, Ura N, Takada T, Agata J, Yoshida H, Miyazaki Y, Shimamoto K: Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats. Am J Hypertens 12: 596-602, 1999
7. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sanchez-Lozada LG: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86: 899-906, 2007
8. Bray GA, Nielsen SJ, Popkin BM: Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 79: 537-543, 2004
9. Douard V, Ferraris RP: Regulation of the fructose transporter GLUT5 in health and disease. Am J Physiol Endocrinol Metab 295: E227-E237, 2008
10. Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T: Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol 293: F1256-F1261, 2007
11. Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY: Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol 20: 545-553, 2009
12. Caudarella R, Vescini F, Buffa A, Francucci CM: Hyperphosphatemia: Effects on bone metabolism and cardiovascular risk. J Endocrinol Invest 30: 29-34, 2007
13. Ganesh SK, Stack AG, Levin NW, Hulbert-Shearon T, Port FK: Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 12: 2131-2138, 2001
14. Marks J, Churchill LJ, Srai SK, Biber J, Murer H, Jaeger P, Debnam ES, Unwin RJ: Intestinal phosphate absorption in a model of chronic renal failure. Kidney Int 72: 166-173, 2007
15. Kirchner S, Muduli A, Casirola D, Prum K, Douard V, Ferraris, RP: Luminal fructose inhibits rat intestinal sodium-phosphate cotrans-porter gene expression and phosphate uptake. Am J Clin Nutr 87: 1028-1038, 2008
16. Tsanzi E, Light HR, Tou JC: The effect of feeding different sugar-sweetened beverages to growing female Sprague-Dawley rats on bone mass and strength. Bone 42: 960-968, 2008
17. Ivaturi R, Kies C: Mineral balances in humans as affected by fructose, high fructose corn syrup and sucrose. Plant Foods Hum Nutr 42: 143-151, 1992
18. Milne DB, Nielsen FH: The interaction between dietary fructose and magnesium adversely affects macromineral homeostasis in men. J Am Coll Nutr 19: 31-37, 2000
19. Wyshak G: Teenaged girls, carbonated beverage consumption, and bone fractures. Arch Pediatr Adolesc Med 154: 610-613, 2000
20. Lee O, Bruce WR, Dong Q, Bruce J, Mehta R, O'Brien PJ: Fructose and carbonyl metabolites as endogenous toxins. Chem Biol Interact 178: 332-339, 2009
21. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ: Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119: 1322-1334, 2009
22. Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG: Minireview on regulation of intestinal calcium absorption: Emphasis on molecular mechanisms of transcellular pathway. Digestion 77: 22-34, 2008
23. Fuchs R, Peterlik M: Vitamin D-induced phosphate transport in intestinal brush border membrane vesicles. Biochem Biophys Res Commun 93: 87-92, 1980
24. Xu H, Bai L, Collins JF, Ghishan FK: Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)(2) vitamin D(3). Am J Physiol Cell Physiol 282: C487-C493, 2002
25. Cui XL, Soteropoulos P, Tolias P, Ferraris RP: Fructose-responsive genes in the small intestine of neonatal rats. Physiol Genomics 18: 206-217, 2004
26. Penaranda C, Garcia-Ocana A, Sarasa JL, Esbrit P: Hypertrophy of rabbit proximal tubule cells is associated with overexpression of TGF beta. Life Sci 59: 1773-1782, 1996
27. Ohyama Y, Yamasaki T: Eight cytochrome P450s catalyze vitamin D metabolism. Front Biosci 9: 3007-3018, 2004
28. Prosser DE, Jones G: Enzymes involved in the activation and inactiva-tion of vitamin D. Trends Biochem Sci 29: 664-673, 2004
29. Golab F, Kadkhodaee M, Zahmatkesh M, Hedayati M, Arab H, Schuster R, Zahedi K, Lentsch AB, Soleimani M: Ischemic and non-ischemic acute kidney injury cause hepatic damage. Kidney Int 75: 783-792, 2009
30. Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M: Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 86: 888-894, 2001
31. Hewison M, Zehnder D, Chakraverty R, Adams JS: Vitamin D and barrier function: A novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol 215: 31-38, 2004
32. Rule AD, Larson TS, Bergstralh EJ, Slezak JM, Jacobsen SJ, Cosio FG: Using serum creatinine to estimate glomerular filtration rate: Accuracy in good health and in chronic kidney disease. Ann Intern Med 141: 929-937, 2004
33. Sakaki T, Kagawa N, Yamamoto K, Inouye K: Metabolism of vitamin D3 by cytochromes P450. Front Biosci 10: 119-134, 2005
34. Inaba M, Yukioka K, Furumitsu Y, Murano M, Goto H, Nishizawa Y, Morii H: Positive correlation between levels of IL-1 or IL-2 and 1,25(OH)2D/25-OH-D ratio in synovial fluid of patients with rheumatoid arthritis. Life Sci 61: 977-985, 1997
35. Cachofeiro V, Goicochea M, de Vinuesa SG, Oubina P, Lahera V, Luno J: Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl S4-S9, 2008
36. Armbrecht HJ, Boltz MA, Bruns ME: Effect of age and dietary calcium on intestinal calbindin D-9k expression in the rat. Arch Biochem Bio-phys 420: 194-200, 2003
37. Pansu D, Bellaton C, Bronner F: Effect of lactose on duodenal calcium-binding protein and calcium absorption. J Nutr 109: 508-512, 1979
38. Mineo H, Hara H, Kikuchi H, Sakurai H, Tomita F: Various indigestible saccharides enhance net calcium transport from the epithelium of the small and large intestine of rats in vitro. J Nutr 131: 3243-3246, 2001
39. Younes H, Demigne C, Remesy C: Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat. Br J Nutr 75: 301-314, 1996
40. Song Y, Kato S, Fleet JC: Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D9k mRNA. J Nutr 133: 374-380, 2003
41. Rawson NE, Blum H, Osbakken MD, Friedman MI: Hepatic phosphate trapping, decreased ATP, and increased feeding after 2,5-anhydro-D-mannitol. Am J Physiol 266: R112-R117, 1994
42. Kles KA, Wallig MA, Tappenden KA: Luminal nutrients exacerbate intestinal hypoxia in the hypoperfused jejunum. JPEN J Parenter En-teral Nutr 25: 246-253, 2001
43. Sugawara-Yokoo M, Suzuki T, Matsuzaki T, Naruse T, Takata K: Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney. Kidney Int 56: 1022-1028, 1999
44. Vignery A, Baron R: Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec 196: 191-200, 1980
45. Reynolds JL, Joannides AJ, Skepper JN, McNair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM: Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15: 2857-2867, 2004
46. Reeves PG, Rossow KL, Lindlauf J: Development and testing of the AIN-93 purified diets for rodents: Results on growth, kidney calcification and bone mineralization in rats and mice. J Nutr 123: 1923-1931, 1993
47. Benn BS, Ajibade D, Porta A, Dhawan P, Hediger M, Peng JB, Jiang Y, Oh GT, Jeung EB, Lieben L, Bouillon R, Carmeliet G, Christakos S: Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology 149: 3196-3205, 2008
48. Jiang L, Ferraris RP: Developmental reprogramming of rat GLUT-5 requires de novo mRNA and protein synthesis. Am J Physiol Gastroi-ntest Liver Physiol 280: G113-G120, 2001
49. Douard V, Cui XL, Soteropoulos P, Ferraris RP: Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function. Endocrinology 149: 409-423, 2008